Abstract: The present invention provides use of compounds which are polyunsaturated fatty acid (PUFA) derivatives of formula (I), in the form of racemates, stereoisomers or mixtures of stereoisomers, or pharmaceutically acceptable salts, or solvates thereof, wherein -AIk- is —(CH2)4—CH(OR2)-[trans]CH?CH-[cis]CH?CH—, —(CH2)4-[cis]CH?CH-[trans]CH?CH—CH(OR2)—, —CH(OR2)-[trans]CH?CH-[cis]CH?CH—CH2-[cis]CH?CH—(CH2)3—, —(CH2)3—CH(OR2)-[trans]CH?CH-[cis]CH?CH—CH2-[cis]CH?CH—, or —(CH2)3-[cis]CH?CH—CH2-[cis]CH?CH-[trans]CH?CH—CH(OR2)—; R1 is a hydrogen atom; or R1 is a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C3-C7 carbocyclyl or 5- to 10-membered heterocyclyl group; or R1 is a group of formula —CH2—CH(OR3)—CH2—(OR4), wherein R3 and R4 are each independently hydrogen atoms or —(C?O)—R6, wherein R6 is an aliphatic group having from 3 to 29 carbon atoms; or R1 is a group of formula —(CH2OCH2)mOH, wherein m is an integer of from 1 to 200; or R1 is a drug moiety; each R2 is the-same or
Type:
Application
Filed:
April 22, 2010
Publication date:
May 17, 2012
Applicant:
Equateq Limited
Inventors:
Adam Kelliher, Norman Camaron, Angus Morrison, Phil Knowles