Abstract: Provided herein are methods of treating a hepatitis E virus (HEV) infection in a human patient are provided. The methods comprise administering to the patient a therapeutically effective amount of interferon lambda.

Abstract: The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: The current invention provides new methods and means for the prevention and treatment of ageing-related symptoms and diseases. The invention discloses Mannitol 5 and/or proline containing compositions that are particularly useful for the treatment of premature ageing related symptoms in mammalian subjects suffering from genetic defects in DNA damage response and genome maintenance pathways. Humans suffering from Cockayne syndrome (CS), Xerodema pigmentosum (XP), combined XPCS, trichothiodystrophy (TTD), COFS (cerebro-oculo-facio-skeletal syndrome), 10 XFE disorder (Xpf-Erccl syndrome), Bloom Syndrome (BS), Werner Syndrome (WS), Ataxia telangiectasia (AT), Fanconi Anemia (FA), Hutchinson Guilford Progeria (HGP) may be treated with pharmaceutical compositions comprising mannitol and/or proline according to this invention.

Abstract: Control device for a computer mouse. In order to enhance comfort as much as possible and to avoid or even cure RSI phenomena, a control is proposed with a curved finger-supporting element and thumb-supporting element with varying curvatures. Optimum support for the hand and fingers (thumb) is obtained if there is a certain correlation between the length over which the hand, including the fingers, is supported and the width available for supporting the fingers. This value is preferably in the range 0.3-0.6 and more specifically is 0.45. Furthermore, the curvature and height of the finger-supporting element and thumb-supporting element must be implemented such that they are a function of the length of the control device. According to a particular embodiment the finger-supporting element is implemented such that, when viewed transversely, this descends from the highest point in a circle.

Abstract: The current invention provides new methods and means for the prevention and treatment of ageing-related symptoms and diseases. The invention discloses mannitol 5 and/or proline containing compositions that are particularly useful for the treatment of premature ageing related symptoms in mammalian subjects suffering from genetic defects in DNA damage response and genome maintenance pathways. Humans suffering from Cockayne syndrome (CS), Xeroderma pigmentosum (XP), combined XPCS, trichothiodystrophy (TTD), COFS (cerebro-oculo-facio-skeletal syndrome), 10 XFE disorder (Xpf-Erccl syndrome), Bloom Syndrome (BS), Werner Syndrome (WS), Ataxia telangiectasia (AT), Fanconi Anemia (FA), Hutchinson Guilford Progeria (HGP) may be treated with pharmaceutical compositions comprising mannitol and/or proline according to this invention.

Abstract: Gene signatures, specific marker genes, and diagnostic assays for predicting progression free survival and objective response to anti-estrogen, e. g., tamoxifen therapy for recurring breast cancer patients are described.

Abstract: Operating device such as a mouse for operating a computer or the like. This device consists of a flat bearing surface on which a bulbous part has been arranged. This bulbous part consists of three (curved) surfaces, a surface for the palm of the hand for supporting the metacarpus/carpus, a central surface for supporting the proximal phalanges of the fingers and a distal surface for supporting the medial and distal phalanges. According to the present invention, the distal surface is made at an angle of approximately 75° with respect to the bearing surface. As a result of this angle there is optimum support for the fingers over the entire contour and it is possible to prevent RSI-like phenomena by preventing lifting movements of the fingers, which in the long term give rise to RSI-like phenomena.