Abstract: The present invention relates to inhalation formulations of drugs in the form of dry powder for inhalation administration deliverable as such with an inhaler and provided with high deliverability, respirability and stability. In particular, the invention relates to a pharmaceutical composition for inhalation in the form of powder comprising at least a first and a second powder, in which at least said first powder contains an active agent in an amount greater than 1% by weight with respect to the weight of said first powder. Both the powders comprise leucine in an amount ranging from 5 to 70% by weight with respect to the weight of each powder and a sugar in an amount ranging from 20 to 90% by weight with respect to the weight of each powder. The composition has a fine particle fraction (FPF) greater than 60% and a delivered fraction (DF) greater than 80.
Type:
Application
Filed:
April 9, 2014
Publication date:
February 18, 2016
Applicant:
ERATECH S.R.L.
Inventors:
Giovanni Caponetti, Loretta Maggi, Cristina Veneziani, Paolo Ventura, Laura Zanellotti
Abstract: Provided is an inhalatory pharmaceutical composition that comprises a drug, a soluble excipient and a surfactant, wherein the soluble excipient is present in an amount between 10% and less than 100% by weight; and the solid excipient forms a solid matrix in which the drug is dispersed; the weight ratio between the surfactant and drug is between 0.01 and 10; the particle size of at least 50% of the particles of the powder is below 5 ?m; the bulk density db of the powder is between 0.1 and 0.3 g/cc; the tapped density dt of the powder is between 0.15 and 0.7 g/cc and the ratio db/dt is between 0.2 and 0.65. Also provided is the method for fabricating the composition.
Type:
Grant
Filed:
October 20, 2006
Date of Patent:
September 22, 2015
Assignee:
Eratech S.R.L.
Inventors:
Giovanni Caponetti, Loretta Maggi, Laura Zanellotti, Cristina Veneziani
Abstract: Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
Type:
Grant
Filed:
April 21, 2005
Date of Patent:
August 28, 2012
Assignee:
Eratech S.r.l.
Inventors:
Giovanni Caponetti, Mariella Artusi, Loretta Maggi, Paolo Corvi Mora
Abstract: Inhalatory pharmaceutical composition comprising a drug, a soluble excipient and a surfactant, characterized by: said soluble excipient is present in an amount between 10% and less than 100% by weight; —the weight ratio between said surfactant and said drug is between 0.01 and 10; —the particle size of at least 50% of the particles of said powder is below 5 ?m; —the bulk density db of said powder is between 0.1 and 0.3 g/cc; —the tapped density dt of said powder is between 0.15 and 0.7 g/cc; —the ratio db/dt is between 0.2 and 0.65.
Type:
Application
Filed:
October 20, 2006
Publication date:
September 18, 2008
Applicant:
ERATECH S.R.L.
Inventors:
Giovanni Caponetti, Loretta Maggi, Laura Zanellotti, Cristina Veneziani
Abstract: Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
Type:
Application
Filed:
April 21, 2005
Publication date:
September 27, 2007
Applicant:
ERATECH S.R.L.
Inventors:
Giovanni Caponetti, Mariella Artusi, Loretta Maggi, Paolo Corvi Mora