Abstract: Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.
Type:
Application
Filed:
April 4, 2018
Publication date:
October 10, 2019
Applicant:
Eriochem USA, LLC
Inventors:
Jose Lucio Nunez, Dante Selenscig, Maria de los Angeles Ramirez
Abstract: Lipid nanoparticles and methods of making and using the same, including pharmaceutical compositions and kits, and the targeted delivery of drugs in various treatment methods. The nanoparticle formulation includes phospholipids, triglycerides, cholesterol, cholesteryl ester, apolipoprotein E3 (ApoE3), and a lipophilic therapeutic agent.
Type:
Application
Filed:
September 28, 2017
Publication date:
February 14, 2019
Applicant:
Eriochem USA, LLC
Inventors:
Jose Lucio NUNEZ, Dante SELENSCIG, Maria de los Angeles RAMIREZ
Abstract: An injectable pharmaceutical formulation of Melphalan comprising a solid composition of melphalan hydrochloride lyophilized with a content of impurities up to 1.3% (p/p)and a pH buffer solution; a process to prepare said solid composition. Also a reconstituted solution of melphalan comprising a solid composition of melphalan lyophilized reconstituted wherein said solution is aqueous, a perfusion free of organic solvent and a kit.
Type:
Application
Filed:
July 4, 2011
Publication date:
May 23, 2013
Applicant:
ERIOCHEM
Inventors:
José Castillo, José Bernardo Iturraspe, José Lucio Nuñez
Abstract: A pharmaceutical formulation of taxane to be administered to mammals, preferably humans, including two compositions which are combined prior to their administration, forming a transparent solution free from precipitates and essentially free from foam, wherein said compositions comprise a solid composition of taxane and a solubilizing composition of said solid taxane composition comprising a tensoactive and an antifoam agent. A kit for such a formulation of injectable taxane includes a prefilled syringe. Also there is a pharmaceutical taxane perfusion solution.
Type:
Application
Filed:
March 30, 2010
Publication date:
October 7, 2010
Applicant:
ERIOCHEM S.A.
Inventors:
José Lucio Nuñez, José Bernardo Iturraspe, Guillermo Norberto Moroni, Esteban Lorenzón
Abstract: A lyophilized solid composition of taxane (preferably docetaxel and paclitaxel), is suitable to prepare a pharmaceutical formulation to be administered to mammals, particularly humans, comprising a taxane, a tensoactive, a lyophilizing excipient, and acid; also essentially free from organic solvents. The solid composition is free from polysorbate 80 and polyoxyethylated castor oil; it is sterile; it is soluble in aqueous solutions in the absence of organic solvent and it has an apparent density from 0.05 g/ml to 0.45 g/ml. A procedure of double lyophilization obtains a solid composition of taxane. A pharmaceutical formulation of a taxane comprises a solid composition of lyophilized taxane and a solubilizing composition. A kit comprises the compositions and a syringe.
Type:
Application
Filed:
January 19, 2007
Publication date:
August 27, 2009
Applicant:
ERIOCHEM, S.A.
Inventors:
Antonio Osvaldo Bouzada, Jose Lucio Nunez, Jose Bernardo Iturraspe, Nora Adriana Moyano De Iturraspe
Abstract: A pharmaceutical formulation of taxane intended to be administered to mammals, preferably humans, comprises two compositions combined prior to being administered, forming a transparent solution free from precipitates, in which the compositions comprise a solid composition of lyophilized taxane, free from tensoactives, oils, polymers, solubility enhancers, preservatives and excipients; and a solubilizing composition of the lyophilized taxane solid composition that comprises at least one tensoactive. This formulation is free from polysorbate 80 and polyoxyethylated castor oil. A procedure is provided for the preparation of the solid composition by means of the lyophilization of taxane in a lyophilizing organic solvent. A kit for the injectable formulation of taxane comprises a prefilled syringe. Also a pharmaceutical taxane solution for perfusion, free from organic solvent, is provided.
Type:
Application
Filed:
January 18, 2007
Publication date:
August 27, 2009
Applicant:
ERIOCHEM S.A.
Inventors:
Antonio Osvaldo Bouzada, Jose Lucio Nunez, Jose Bernardo Iturraspe, Nora Adriana Moyano De Iturraspe
Abstract: A process for the manufacturing of microcapsules for sustained release of water soluble peptides, with adjustable release periods of between 1 to 18 weeks. The microcapsule wall are made of a biodegradable polymer. The process is based on the formation of an intermediate complex water/oil/water emulsion. By evaporating the solvent in the emulsion by pressure reduction the microcapsules consolidate, retaining the active peptides in the polymeric matrix. The process produces the complex emulsion in a two mixer, continuous operation. In the first mixer a water/oil emulsion is formed and it is used to form the complex emulsion in the second mixer. By operating in a continuous manner, the process overcome the problems found in existing processes regarding particle size distribution, material losses and process control, among others.
Type:
Grant
Filed:
May 3, 2001
Date of Patent:
March 18, 2003
Assignee:
Eriochem S.A.
Inventors:
Nora Moyano, Jose Iturraspe, Jose Lucio Nunez