Abstract: Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.
Type:
Application
Filed:
April 4, 2018
Publication date:
October 10, 2019
Applicant:
Eriochem USA, LLC
Inventors:
Jose Lucio Nunez, Dante Selenscig, Maria de los Angeles Ramirez
Abstract: Lipid nanoparticles and methods of making and using the same, including pharmaceutical compositions and kits, and the targeted delivery of drugs in various treatment methods. The nanoparticle formulation includes phospholipids, triglycerides, cholesterol, cholesteryl ester, apolipoprotein E3 (ApoE3), and a lipophilic therapeutic agent.
Type:
Application
Filed:
September 28, 2017
Publication date:
February 14, 2019
Applicant:
Eriochem USA, LLC
Inventors:
Jose Lucio NUNEZ, Dante SELENSCIG, Maria de los Angeles RAMIREZ