Abstract: New therapeutic use of Polypodium extract. A new use of Polypodacea genus extracts is described for the treatment of fibrotic pathologies, such as, scleroderma, pulmonary fibrosis, atherosclerosis, bone marrow fibrosis, liver fibrosis, pancreatic fibrosis, kidney fibrosis, cardiac fibrosis, Dupuytrem's disease and, specially, Peyronie's disease; said fibrotic pathologies are produced by an extracellular matriz (ECM) overexpresion, and by a Transforming Growth Factor (TFG-?) overexpression. It is disclosed extracellular matriz inhibition in vitro; and penis tunica albuginea reduction and plaque redution in patients who suffer Peyronie's diseaseas after Polypodium extracts administration. In a preferred mode, Polypodium extracts are obtained from Polypodium leucotomos rhizomes and extraction with a polar solvent.

Abstract: Pharmaceutical composition with adhesion molecule expression regulating activity. The invention relates to a novel pharmaceutical application of a pharmaceutical composition exhibiting regulating activity of the expression of adhesion molecules integrins, selectins and immunoglobulins and its application as anti-inflammatory agent. Said pharmaceutical composition contains Anapsos, a water-soluble extract and a lipo-soluble extract of the rhizomes of Polypodium leucotomos as active substance in addition to acceptable excipients.

Abstract: A pharmaceutical composition with beneficial effects in disorders which deal with cognitive, neurodegenerative and/or neuroimmune dysfunctions, especially the Alzheimer disease, characterized in that it comprises, as active ingredient, an isolated, natural hydrosoluble extract of the rhizome or leaves of Phlebodium decumanum, Polypodium aureum, Polypodium leucotomos, Polypodium vulgare, Polypodium trisereiale, Pteridium aquilinum, Dryopteris crassirhizoma and Cyathea taiwamiana, and the liposoluble fraction derivates of said extract, together with an acceptable pharmaceutical vehicle.