Patents Assigned to ESSENLIX CORPORATION
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Publication number: 20240125705Abstract: The present invention provides, among other things, devices, kits, apparatus, and methods for rapid homogenous cell staining and imaging. Particularly, in some embodiments, the present invention can immunochemically stain a cell or a tissue in less than 60 seconds without washing. In some embodiments, the present invention stains and observes analyte (protein or nucleic acid) inside a cell in 60 seconds without washing.Type: ApplicationFiled: December 19, 2023Publication date: April 18, 2024Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING, Ji LI, Shengjian Cai, Yufan Zhang, Jia Peng
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Patent number: 11940443Abstract: Among other things, the present invention is related to bio/chemical sampling, sensing, assays and applications.Type: GrantFiled: January 25, 2019Date of Patent: March 26, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
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Patent number: 11940382Abstract: A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.Type: GrantFiled: February 8, 2018Date of Patent: March 26, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi, Ji Li
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Patent number: 11933720Abstract: The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.Type: GrantFiled: June 22, 2020Date of Patent: March 19, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Qi, Jun Tian, Wu Chou, Hongbing Li
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Publication number: 20240085304Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.Type: ApplicationFiled: January 18, 2022Publication date: March 14, 2024Applicant: Essenlix CorporationInventors: Xing LI, Wu CHOU, Stephen Y. CHOU, Wei DING, Ji QI
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Patent number: 11927560Abstract: Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip.Type: GrantFiled: February 8, 2018Date of Patent: March 12, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Yufan Zhang
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Patent number: 11927533Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.Type: GrantFiled: November 11, 2022Date of Patent: March 12, 2024Assignee: Essenlix CorporationInventors: Ji Qi, Stephen Y. Chou, Wei Ding
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Patent number: 11906432Abstract: The present invention provides, among other things, devices, kits, apparatus, and methods for rapid homogenous cell staining and imaging. Particularly, in some embodiments, the present invention can immunochemically stain a cell or a tissue in less than 60 seconds without washing. In some embodiments, the present invention stains and observers analyte (protein or nucleic acid) inside a cell in 60 seconds without wash.Type: GrantFiled: August 23, 2019Date of Patent: February 20, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Li, Shengjian Cai, Yufan Zhang, Jia Peng
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Publication number: 20240042428Abstract: A device for liquid sample collection and liquid sample analysis, including: a base plate having: at least one pedestal area in at least a portion of a sample image area; and at least one recessed area, wherein at least of a portion of the at least one pedestal area is adjacent to the at least one recessed area; a cover plate that opposes the base plate; a plurality of spacers attached to one of the base plate, the cover plate, or both, and the spacers are situated between the opposable plates; and an exterior liquid sample contact area on an exterior location of the device; wherein the base plate and the cover plate define an interior cavity in fluid communication with the exterior liquid sample contact area. Also disclosed are an apparatus including the device, a method of making the device, and a method of using the device.Type: ApplicationFiled: December 7, 2021Publication date: February 8, 2024Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING
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Publication number: 20240035954Abstract: The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.Type: ApplicationFiled: May 1, 2023Publication date: February 1, 2024Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING, Wu CHOU, Jun TIAN, Yuecheng ZHANG, Mingquan WU, Xing LI
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Patent number: 11883824Abstract: Disclosure relates to a device and a method of using the device for conducting biological and chemical assays on a sample. The device includes two plates. The first plate includes at least a first and a second sample contact areas on its inner surface. Each sample contact area includes spacers having a bottom end fixed on the inner surface and a top end that is distal to the inner surface. The spacers in the first sample contact area differ in height from those in the second sample contact area. The first and second sample contact areas are disposed at different depths along the inner surface of the first plate, so that the top ends of the spacers are aligned on the same flat plane. The method includes depositing the sample onto the sample contact areas, compressing the sample into a thin layer, and analyzing the sample.Type: GrantFiled: February 9, 2018Date of Patent: January 30, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang
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Patent number: 11885952Abstract: A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.Type: GrantFiled: July 30, 2019Date of Patent: January 30, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Qi, Yuecheng Zhang, Wu Chou, Mingquan Wu, Xing Li, Jun Tian
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Publication number: 20240027430Abstract: The disclosure provides a method for identifying a bio-entity including a cell type and count in a sample. The method includes: providing a device comprising a first plate, a second plate, and a patterned structural element; depositing the sample between the first and second plates; reducing the spacing of the first and second plates so that the first and second plates are in a closed configuration to compress the sample into a layer; and imaging the sample to obtain an image; and measuring and analyzing the image against a database generated with a machine learning model to obtain the bio-entity of the sample. The sample can be a blood sample, and the method can be a white blood cell differential test conducted with a mobile phone.Type: ApplicationFiled: September 26, 2023Publication date: January 25, 2024Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Yu SUN, Wei DING, Ji Qi, Mingquan WU, Shengjian CAI, Wu CHOU
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Publication number: 20240011908Abstract: Among other things, the disclosure of the present invention is related to make pathology and cytology faster, better, and lower cost, as well as to using fast cytology to quickly determine the concentration of the analyte outside a cell in a sample. The present invention is also related to rapid intra-cellular assays.Type: ApplicationFiled: October 29, 2021Publication date: January 11, 2024Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING, Yu Sun, Sheng-Jian Cai, Wei DING
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Publication number: 20230408534Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments, the errors are random. One aspect of the present invention is to overcome the random errors or imperfections of an assay device or the operation of the assay device by measuring, in addition to measuring the analyte in a sample to generate an analyte test result, the trustworthiness of the analyte test result. The analyte test result will be reported, only when the trustworthiness meets a predetermined threshold, otherwise the analyte test result will be discarded. Various of parameter variation have been used for test trustworthy determination.Type: ApplicationFiled: October 8, 2021Publication date: December 21, 2023Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING, Wu CHOU, Xing LI, Mingquan WU
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Patent number: 11846582Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.Type: GrantFiled: July 6, 2022Date of Patent: December 19, 2023Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Qi, Jun Tian, Wu Chou
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Publication number: 20230398545Abstract: One aspect of the present invention is to provide the device and methods for performing an assay that uses the multiplexing of sample thicknesses on the same plate. The sample thickness multiplexing can offer many information that is unavailable in using a single sample thickness.Type: ApplicationFiled: August 15, 2023Publication date: December 14, 2023Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING, Ji Qi, Yufan Zhang
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Publication number: 20230400469Abstract: The present invention is to provide methods and devices that monitoring health and diagnosing a disease by directly measuring the biomarkers inside a cell (intra-cellular detection) rapidly and easily.Type: ApplicationFiled: December 21, 2020Publication date: December 14, 2023Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Susan Y. SUN, Shengjian CAI, Wei DING
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Publication number: 20230358648Abstract: Disclosed are devices and methods for analyzing an analyte, such as white blood cells in liquid samples.Type: ApplicationFiled: May 1, 2023Publication date: November 9, 2023Applicant: Essenlix CorporationInventors: Stephen Y. CHOU, Wei DING, Ji Qi
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Patent number: 11806717Abstract: One aspect of the present invention is to provide the device and methods for performing an assay that uses the multiplexing of sample thicknesses on the same plate. The sample thickness multiplexing can offer many information that are unavailable in using a single sample thickness.Type: GrantFiled: August 16, 2019Date of Patent: November 7, 2023Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang