Abstract: The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a particularly well suited antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
Type:
Grant
Filed:
March 11, 2015
Date of Patent:
August 9, 2016
Assignee:
ESTABECH, an Alcon Biomedical Research Unit LLC