Patents Assigned to ESTEVE PHARMACEUTICALS, S.A.
  • Spiro-isoquinoline-4,4?-piperidine compounds having multimodal activity against pain
    Patent number: 10508114
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to spiro-isoquinoline-4,4?-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: December 17, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventor: Carmen Almansa-Rosales
  • Substituted amide derivatives having multimodal activity against pain
    Patent number: 10428051
    Abstract: The present invention relates to substituted amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: October 1, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales, Ana Virginia Llorente-Fernandez, Lourdes Garriga-Sanahuja, Ute Christmann
  • Substituted morpholine derivatives having activity against pain
    Patent number: 10421750
    Abstract: The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 24, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carlos Alegret-Molina
  • Spiro-isoquinoline-1,4?-piperidine compounds having multimodal activity against pain
    Patent number: 10407428
    Abstract: The present invention relates to spiro-isoquinoline-1,4?-piperidine compounds having dual pharmacological activity towards both the sigma (?) receptor and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: September 10, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Monica Garcia Lopez, Ana-Maria Caamano-Moure
  • Piperazine derivatives having multimodal activity against pain
    Patent number: 10351535
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 16, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Methyl-1H-pyrazole alkylamine compounds having multimodal activity against pain
    Patent number: 10071968
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to methyl-1H-pyrazole alkylamine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: September 11, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventors: Antoni Torrens-Jover, Josep Mas-Prio, Carmen Almansa-Rosales, Monica Garcia-Lopez
  • Spiro-isoquinoline-3,4?-piperidine compounds having activity against pain
    Patent number: 10072008
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to spiro-isoquinoline-3,4?-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: September 11, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventor: Carmen Almansa-Rosales
  • Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10065971
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. wherein Y is n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, —C(O)O—, —C(O)NR8—, —C(O)—, —O— or —C(R4R4?)—; R1 is C(O)R5 or S(O)2R5.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 4, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Ramón Merce-Vidal
  • 1,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10022359
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to 1,9-diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: July 17, 2018
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carlos Alegret-Molina, Carmen Almansa-Rosales