Abstract: Process for removal of the amino protective group of a N-acylated {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R?H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.
Type:
Grant
Filed:
September 27, 2007
Date of Patent:
May 22, 2012
Assignee:
Esteve Quimica, SA
Inventors:
Jorge Medrano Rupérez, Julio Campon Pardo, Laia Elías Rius, Ramón Berenguer Maimó
Abstract: The invention relates to the new crystalline forms II, III and V of meloxicam; to the processes for obtaining the crystalline forms I, II, III and V; and, finally, to the interconversion processes of the forms II, III, IV and V into the form I.
Type:
Grant
Filed:
December 9, 2002
Date of Patent:
November 22, 2005
Assignee:
Esteve Quimica, SA
Inventors:
Laura Coppi, Marti Bartra Sanmarti, Montserrat Closa Clavo