Patents Assigned to Estonian Biocenter
  • Method to determine single nucleotide polymorphisms and mutations in nucleic acid sequence
    Patent number: 7638310
    Abstract: A genotyping method and a prepared oligomicroarray as device is to determine single nucleotide polymorphism (SNP) and mutations are provided. The method uses two specific APEX-2 primers per each SNP or mutations to be determined. The same primers are used in amplification phase (primer extension and PCR with universal primer) and in the single base extension phase on an array. All SNP-containing sequences can be genotyped and amplified in one reaction tube and visualized on a microarray.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: December 29, 2009
    Assignee: Estonian Biocenter
    Inventors: Kaarel Krjutskov, Andres Metspalu