Abstract: Quinidine derivatives of general formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, or an acyl group, and R.sub.2 represents a hydrogen atom, a hydroxy group, an alkoxy group, an acyloxy group or an aroyloxy group, as well as the acid addition salts thereof, useful in therapy, particularly, for the treatment of cardiac arrhythmia.

Abstract: The present invention relates to new 14-aminosteroids and their application in therapy and also to a process for their preparation.

Abstract: The invention relates to 4-acylamino-1-azaadamantanes represented by general formula (I): ##STR1## wherein R represents an alkyl group, a substituted alkyl group, an aryl group or a substituted aryl group, useful in particular, for the treatment of cardiovascular diseases.

Abstract: The invention relates to 14-amino steroid derivatives of formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group with 1 to 4 carbon atoms, R.sub.1 represents a substituted or unsubstituted sugar residue, and R.sub.2 represents a hydrogen atom, a hydroxyl group or an --OR.sub.3 group, wherein R.sub.3 is a substituted or unsubstituted sugar residue; and acid salts thereof useful in the treatment of cardiac incapacity.

Abstract: The invention relates to new 3-pyridyl-5-alkoxy-pyrazole derivatives of the following formula: ##STR1## wherein R.sub.1 represents a 4-pyridyl, 3-pyridyl or 2-pyridyl group which is unsubstituted or which may be substituted with one or two lower alkyl groups; R.sub.2 represents a hydrogen atom or a lower alkyl group; and R.sub.3 represents a lower alkyl group, a phenyl group or an aralkyl group; and the acid addition salts thereof. The derivatives may be prepared by alkylation of a 3-pyridyl-5-pyrazolone. The derivatives are medicinally useful, particularly for the treatment of cardiac deficiency.

Abstract: The invention relates to new derivatives of spiro compounds represented by the general formula (I) ##STR1## wherein R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; R.sub.1 and R.sub.2 represent a hydrogen atom or an alkyl group or together form a nitrogen-containing heterocyclic ring; A is a>CH.sub.2 group or a>CO group; n is 4 or 5. These compounds can be prepared from .beta.-hydroxyacids by intramolecular rearrangement by the action of a strong acid, in order to form a .gamma.-spirolactone which is converted into an .alpha.-carboxy .gamma.-spirolactone to form the compounds of formula (I) using a Mannich reaction. As necessary, a reduction is then carried out. These compounds are useful medically, in particular, as an antidepressant, a stimulant, and a neuroleptic.

Abstract: The invention relates to new derivatives of spiro compounds represented by the general formula (I) ##STR1## wherein R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; R.sub.1 and R.sub.2 represent a hydrogen atom or an alkyl group or together form a nitrogen-containing heterocyclic ring; A is a >CH.sub.2 group or a >CO group; n is 4 or 5. These compounds can be prepared from .beta.-hydroxyacids by intramolecular rearrangement by the action of a strong acid, in order to form a .gamma.-spirolactone which is converted into an .alpha.-carboxy .gamma.-spirolactone to form the compounds of formula (I) using a Mannich reaction. As necessary, a reduction is then carried out. These compounds are useful medically, in particular, as an antidepressant, a stimulant, and a neuroleptic.

Abstract: An aminoalkoxypyrazole of the general formula (I) ##STR1## wherein Ar is a phenyl, benzyl or naphthyl group, or a phenyl group substituted by one or more halogen atoms, or by one or more alkyl, cyano, nitro, hydroxy or alkoxy groups; R.sub.1 is a hydrogen atom or an alkyl group; R.sub.2 and R.sub.3, which may be the same or different, are a hydrogen atom or an alkyl group, or form, with the nitrogen atom to which they are attached, a 5- to 7-membered heterocyclic ring; n is an integer of from 1 to 4; as well as the mineral or organic acid salts thereof. A further embodiment of the invention is the application of the derivatives of the general formula (I) as medications, in particular, for the treatment of depression, polyfunctional disorders, migraines and cardiovascular diseases.

Abstract: The invention relates to medicinally useful steroid derivatives, particularly amino-14 steroids substituted at the 17-position by a functional group represented by the general formula: ##STR1## wherein R.sub.1 is a hydroxy, hydroxyalkyl, alkoxy, acyloxy, carboxy or carbalkoxy group, or a hydrogen atom, and R.sub.2 is a hydroxy, alkoxy, or acyloxy group. These amino-14 steroids are prepared from the corresponding hydroxy-14 steroids, by the action of hydrazoic acid in the presence of boron trifluoride etherate to form the azido-14 derivative which is reduced.

Abstract: Aminocardenolides of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.4, R.sub.5, and R.sub.6, which may be the same or different, each represents a hydrogen atom or a hydroxy, alkoxy or acyloxy group; R.sub.3 represents a lower alkyl, hydroxyalkyl, acyloxyalkyl, haloalkyl or ethylenedioxyalkyl group; R.sub.7 represents a hydrogen atom, or an alkyl or acyl group, and R.sub.8 represents a hydrogen atom, an alkyl group or an amino acid residue; a process for preparation of the compounds with the above formula by reaction of an oxo-3 genin with an ammonium salt in the presence of a borocyanohydride in an organic solvent. The aminocardenolides of formula (I) are useful especially for the treatment of cardiac ailments.

Abstract: Amino-3-cardenolide derivatives represented by the general formula (I) ##STR1## wherein n and m, which may be the same or different, each represents an integer from 0 to 4; R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or a hydroxy, alkoxy or acyloxy group; R.sub.3 represents a lower alkyl, aldehyde, haloalkyl, hydroxyalkyl, acyloxyalkyl, or ethylenedioxyalkyl group; R.sub.7 represents a hydrogen atom or an alkyl group; R.sub.8 represents a hydrogen atom or an alkyl, acyl, alkyloxycarbonyl or aralkoxycarbonyl group; R.sub.9 represents a hydrogen atom or an alkyl group; R.sub.8 and R.sub.9 can combine and form with the nitrogen atom a heterocyclic ring; R.sub.10 represents a hydroxy, alkoxy or aralkoxy group, an amino residue of amino acid or of an oligo-peptide, useful especially for the treatment of cardiac ailments.

Abstract: Method of oxidizing cinchona alkaloids by reacting specific ketone with cinchona alkaloid in the presence of a strong base and aprotic solvent; following oxidation the oxo compound is reduced to the corresponding stereoisomer.

Abstract: Cardiotonic cardenolide derivatives of the formula ##STR1## wherein n, m, R.sub.1 to R.sub.9 are as hereinafter defined, the mineral or organic salts thereof and a process for their preparation.

Abstract: 1-AMINO-5-ALKOXY-PYRAZOLE COMPOUNDS OF THE FORMULA: ##EQU1## wherein R.sub.1 represents a lower alkyl group having 1 to 4 carbon atoms, R.sub.2 and R.sub.3, which may be identical or different, represent a hydrogen atom, a lower alkyl group, a phenyl group, a phenyl group substituted by one or more groups selected from lower alkyl, halogen, nitro and lower alkoxy; R.sub.4 represents an amino group, a mono-lower alkyl amino group or a di-lower alkyl amino group; as well as their salts with a mineral or organic acid.A method for the preparation thereof, consisting essentially in internally transforming, in the presence of hydrazine, a 5-hydrazino-isoxazole (or 5-halogenoisoxazole) derivative and alkylating the 5-hydroxy-derivative obtained with a suitable diazoalkane.