Patents Assigned to Etex Corporation
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Patent number: 9427715Abstract: Bone cement mixing and delivery device and methods are disclosed. The device includes a first tube/barrel (e.g., a syringe barrel) containing a bone cement powder and a second tube/barrel that can be filled with or that contains a liquid; the first and second tubes/barrels can be fluidly connected end-to-end such that there is fluid communication between the tubes/barrels. Also disclosed are methods of preparing the device for use, methods for forming a bone cement using the device, and methods and device design to extend the shelf life of the device.Type: GrantFiled: August 28, 2008Date of Patent: August 30, 2016Assignee: ETEX CorporationInventors: Robert Palazzolo, Manish Sutaria, Aliassghar N. Tofighi, Tak L. Chang, Aron D. Rosenberg
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Patent number: 8728536Abstract: A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.Type: GrantFiled: March 30, 2006Date of Patent: May 20, 2014Assignee: Etex CorporationInventor: Maria Aiolova
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Patent number: 8545858Abstract: Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.Type: GrantFiled: April 3, 2012Date of Patent: October 1, 2013Assignee: Etex CorporationInventors: Aron D. Rosenberg, Laurent D. Gillès de Pélichy, Shrikar Bondre, Michael Strunk
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Patent number: 8507008Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.Type: GrantFiled: July 2, 2010Date of Patent: August 13, 2013Assignees: ETEX Corporation, Wyeth LLCInventors: Rebecca Li, Howard Seeherman, Hyun Kim
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Patent number: 8454988Abstract: Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo.Type: GrantFiled: January 23, 2008Date of Patent: June 4, 2013Assignee: Etex CorporationInventors: Aron D. Rosenberg, Laurent D. Gilles de Pelichy, Daniel Egan, Aliassghar N. Tofighi, Youngmi M. Lee
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Patent number: 8333996Abstract: An improved calcium phosphate delivery vehicle or adjuvant with incorporated adjuvanticity enhancing means and methods of producing same are disclosed. The adjuvant can be fabricated to desired formulations as appropriate and based on the intended purpose. Particle sizes can be adjusted to enhance adjuvant activity. Other supplemental materials may be added as desired and in appropriate proportions to selectively elicit preferred components of the immune system and to enhance the adjuvant's effect on the host response.Type: GrantFiled: September 15, 1998Date of Patent: December 18, 2012Assignee: Etex CorporationInventors: D. Duke Lee, Maria Aiolova
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Publication number: 20120282301Abstract: Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.Type: ApplicationFiled: April 3, 2012Publication date: November 8, 2012Applicant: Etex CorporationInventors: Aron D. Rosenberg, Laurent D. Gillès de Pélichy, Shrikar Bondre, Michael Strunk
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Patent number: 8221781Abstract: Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo.Type: GrantFiled: April 12, 2004Date of Patent: July 17, 2012Assignee: Etex CorporationInventors: Aron D. Rosenberg, Laurent D. Gilles de Pelichy, Daniel Egan, Aliassghar N. Tofighi, Dosuk D. Lee
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Patent number: 8216359Abstract: The invention features delayed-setting calcium phosphate pastes which are useful for the preparation of delivery vehicles for biologically active agents, useful for the treatment of orthopedic conditions and can be stored for long periods without prematurely setting.Type: GrantFiled: April 14, 2005Date of Patent: July 10, 2012Assignee: ETEX CorporationInventors: Dosuk D. Lee, Youngmi M. Lee, legal representative, Aron D. Rosenberg, Laurent D. Gilles De Pelichy, Manish Sutaria, Aliassghar N. Tofighi
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Patent number: 8147860Abstract: Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.Type: GrantFiled: December 6, 2005Date of Patent: April 3, 2012Assignee: ETEX CorporationInventors: Aron D. Rosenberg, Laurent D. Gillès de Pélichy, Shrikar Bondre, Michael Strunk
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Patent number: 8003133Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.Type: GrantFiled: September 23, 2009Date of Patent: August 23, 2011Assignees: Wyeth LLC, Etex CorporationInventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
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Patent number: 7771755Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.Type: GrantFiled: September 10, 2004Date of Patent: August 10, 2010Assignees: Wyeth, Etex CorporationInventors: Rebecca Li, Howard Seeherman, Hyun Kim
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Publication number: 20100074876Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.Type: ApplicationFiled: September 23, 2009Publication date: March 25, 2010Applicants: Wyeth, Etex CorporationInventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
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Patent number: 7622139Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.Type: GrantFiled: December 17, 2007Date of Patent: November 24, 2009Assignees: Wyeth, ETEX CorporationInventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
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Patent number: 7582309Abstract: Demineralized bone matrix fibers and a demineralized bone matrix composition are provided. The demineralized bone matrix fibers have an average fiber length in the range from about 250 ?m to about 2 mm and an aspect ratio of greater than about 4. The demineralized bone matrix composition includes demineralized bone matrix fibers and a biocompatible liquid in an amount to produce a coherent, formable mass. The formable mass retains its cohesiveness when immersed in a liquid. Methods for making the demineralized bone matrix fibers and composition are also provided.Type: GrantFiled: November 15, 2002Date of Patent: September 1, 2009Assignee: Etex CorporationInventors: Aron D. Rosenberg, Laurent Gilles de Pelichy
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Patent number: 7517539Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.Type: GrantFiled: October 16, 1997Date of Patent: April 14, 2009Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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Patent number: 7413753Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.Type: GrantFiled: May 31, 2002Date of Patent: August 19, 2008Assignees: Wyeth, Etex CorporationInventors: Rebecca H. Li, Howard Seeherman
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Publication number: 20080188946Abstract: Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo.Type: ApplicationFiled: January 23, 2008Publication date: August 7, 2008Applicant: Etex CorporationInventors: Aron D. Rosenberg, Laurent D. Gilles de Pelichy, Daniel Egan, Aliassghar N. Tofighi, Dosuk D. Lee, Youngmi M. Lee
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Publication number: 20080096797Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.Type: ApplicationFiled: December 17, 2007Publication date: April 24, 2008Applicants: Wyeth, Etex CorporationInventors: Rebecca Li, Howard Seeherman, Aliassghar Tofighi
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Patent number: 7318841Abstract: A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.Type: GrantFiled: August 16, 2002Date of Patent: January 15, 2008Assignee: Etex CorporationInventors: Aliassghar Tofighi, Christian Rey