Abstract: System for producing somatotopic sensations using Transcutaneous Electrical Nerve Stimulation (TENS) in the lower limbs is provided, the system comprising a wearable device to be attached to a lower limb of an individual, the wearable device comprising at least two units, each comprising one or more arrays of TENS electrodes to be associated with at least one nerve of the lower limb, and wherein the system is configured to select electrodes of at least one array of electrodes, and stimulation signal parameters to be thereto, and control the stimulation of at least one nerve associated with the array of electrodes comprising the selected electrodes.

Abstract: A steerable device includes an elongated element configured to be navigated through the mammalian body. The elongated element has a device tip configured for allowing steering of the elongated element by way of an external magnetic field. Further, the device tip includes a plurality of segments, each segment including a segment body and a segment interface, and a plurality of connectors, each connector including a connector body and a connector interface. The connector interfaces and the segment interfaces have each time mutually complementing shapes allowing rotational movements relative to each other and forming a connection to retain the connectors and the segments in a mated condition, and the magnetic elements form at least partially segment bodies or connector bodies or both.

Abstract: The present invention relates to a method for recording a transcriptome of a cell by: providing a test cell that includes a first transgene nucleic acid sequence encoding a fusion protein that is a reverse transcriptase polypeptide and a Cas1 polypeptide and a second transgene nucleic acid sequence encoding a Cas2 polypeptide, wherein the first transgene nucleic acid sequence and the second transgene nucleic acid sequence are under transcriptional control of an inducible promoter sequence, and a third transgene nucleic acid sequence including a CRISPR direct repeat (DR) sequence; wherein the CRISPR direct repeat sequence is specifically recognizable by a RT-Cas1-Cas2 complex formed by the expression products of the first transgene nucleic acid sequence and the second transgene nucleic acid sequence.

Abstract: The present invention relates to fibronectin-binding peptides according to the sequence FnI5BS-L1-FnI4BS-L2-FnI3BS-L3-FnI2BS which are useful in tumor or fibrosis diagnosis and therapy. Instant peptides show improved fibronectin-binding and biodistribution properties compared to the prior art. Furthermore, instant peptides may be conjugated to a payload and are useful in the treatment and/or prevention of diseases associated with pathological fibronectin accumulation, including cancer and fibrosis. Instant peptides are also useful in diagnosis of diseases associated with pathological fibronectin accumulation, including cancer and fibrosis.

Abstract: The invention relates to a method, particularly a computer-implemented method for determining a fatigue value of a person, the method comprising the steps of: i) displaying of: a) a first group (1) of symbols and a second group (2) of symbols, b) a selection rule (3) associating each of the symbols of the first group (1) of symbols to one symbol of the second group (2) of symbols, ii) highlighting one symbol (11) of the first group (1) of symbols, iii) receiving a user input from the person selecting one symbol (12) of the second group (2) of symbols, iv) determining a truth value based on the selected symbol (12) of the second group (2) of symbols, wherein the truth value assumes a true value if the selected symbol (12) is selected in accordance with the selection rule (3) and wherein the truth value takes on a false value if not, wherein the highlighted symbol (11) of the first group (1) of symbols is highlighted for a predetermined time based on a statistical response time of the person, and wherein

Abstract: The present disclosure relates to genetically modified plants including a modified POTASSIUM TRANSPORTER 2 (AKT2) protein or an overexpressed AKT2 protein. The present disclosure further relates to methods of producing genetically modified plants including the modified AKT2 protein or the overexpressed AKT2 protein. In addition, the present disclosure relates to genetically modified plants with improved photosynthesis, higher rate of CO2 fixation and/or electron transport rate, improved yield under different growing conditions, and improved storage root or tuber growth.

Abstract: A steerable device for use inside of a mammalian body, including an elongated element and a flexible device tip which includes a tubular section and a plurality of permanent magnetic elements disposed in the tubular section. Each magnetic element has an axial bore and the axial bores form an axial conduit in which a core wire extends. The axial bore extends from a first to a second axial end of the magnetic element opposed to the first axial end. First axial ends and second axial ends have a bevel allowing movement of the magnetic elements against one another, wherein the bevel of axial ends of adjacent magnetic elements is rounded with a different radius or flat with a different angle to the longitudinal axis to control bending of the device tip.

Abstract: The present invention relates to a hydrogel that can be used to prevent or treat endometriosis and as mechanical contraception.

Abstract: The present technology provides nanocomposite compositions that include about 0.1 wt. % to about 40 wt. % of nanoparticles having a net cationic charge by weight of the composition; about 0.1 wt. % to about 50 wt. % of one or more gelling agents by weight of the composition; and a solvent that includes a protic solvent. Methods of preparing a three-dimensional structure via the nanocomposite composition are also disclosed.

Abstract: The present invention provides a method for generating a bone fixation implant and related preoperative planning. The method comprises a first step of determining at least the orientation and the position of the fixation means, based on a 3D model of the bone fragments. The method may include a second step of defining the shape of one or more bone plates, based on the output of the first step. The method may further include a third step determining tools for applying fixation means during surgery, according the optimized configuration defined in the first step and applying the bone plates from the second step. The method may even further include a fourth step, quantifying construct stability for a given patient following surgery, thereby allowing early weightbearing.

Abstract: A neural network, a system using this neural network and a method for training a neural network to output a description of the environment in the vicinity of at least one sound acquisition device on the basis of an audio signal acquired by the sound acquisition device, the method including: obtaining audio and image training signals of a scene showing an environment with objects generating sounds, obtaining a target description of the environment seen on the image training signal, inputting the audio training signal to the neural network so that the neural network outputs a training description of the environment, and comparing the target description of the environment with the training description of the environment.

Abstract: A composition including a temperature sensitive biocompatible solder and at least one type of nanoparticles, characterized in that a first type of nanoparticles is a fluorescent nanothermometer, wherein the fluorescent nanothermometer exhibits an excitation maximum and temperature dependent emission spectrum each in the range of between 650 and 1350 nm. The composition can be used for laser tissue soldering.

Abstract: The present invention provides additive manufacturing compositions, also referred as “inks” in the field of additive manufacturing, which can be fine-tuned with respect to porosity by varying the intensity of the photopolymerisation light source and which can further be used to obtain objects out of glasses, ceramics or glass-ceramics and their respective alloys.

Abstract: The present invention relates to energy storage systems and reactors useful in such systems. Inventive reactors comprise a reaction vessel defining an inner volume and a compensation element, whereby said inner volume is filled with a fixed bed that is free of cavities and that comprises particles of formula (I), FeOx (I), where 0?x?1.5; said compensation element is adapted to adjust said inner volume. The reactors are inherently explosion proof and thus suited for domestic use. The systems are useful for compensating long-term fluctuations observed in production of renewable energy.

Abstract: The present disclosure relates to a method for producing calcium carbonate solids from alkaline minerals including the following method steps: Supplying alkaline minerals and an extraction agent into a reactor tank. Stirring the alkaline minerals and the extraction agent in the reactor tank such that a first suspension is formed. Draining of the first suspension from the reactor tank and separating a liquid phase comprising calcium from the first suspension and transferring the liquid phase into a carbonation tank. Supplying a gas comprising CO2 into the carbonation tank, wherein the consumption of CO2 results in the precipitation of calcium carbonate solids thereby generating a second suspension and nucleating and growing of the calcium carbonate solids. Furthermore, a measure of the consumed CO2 is determined by at least one sensor.

Abstract: The present invention relates to a time-continuous neural network circuit implemented on analog hardware with device mismatch, the circuit including a control unit (40) which is individually connected to each respective neuron of the circuit, the neurons in the hidden and output layers comprising a forward compartment for processing signals coming from preceding layers, a feedback compartment for processing feedback signals coming from the control unit and a central compartment for generating and sending a signal to the next layer or to the control unit. The control unit generates and sends to the feedback compartment of each respective neuron a feedback signal (Sf) based on the comparison between a network output signal (Sout) and a target signal (Star).

Abstract: A method of producing an alloy including magnesium and calcium, preferably an implantable medical device having magnesium and calcium, includes the steps of generating a billet including magnesium and calcium, and extruding the billet. The billet is extruded at least once at an extrusion temperature in the range of 250° C. to 450° C. and at a ram speed in the range of 0.01 mm/s to 1 mm/s and at an extrusion ratio in the range of 20 to 150 and preferably at an extrusion ratio in the range of 35 to 150.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: The invention relates to the fields of biomolecular computing and/or synthetic biology. In particular, the invention relates to a DNA construct that comprises a first promoter, at least one further promoter and an output sequence, wherein each of said promoters comprises a transcription start site and/or is suitable for initiating transcription, wherein the initiation of transcription from the first promoter is enabled by a first transcriptional regulatory state and the initiation of transcription from each of said further promoter(s) is enabled by a respective further transcriptional regulatory state, and wherein said DNA construct yields an effective amount of an output RNA in a eukaryotic cell, when said first transcriptional regulatory state and/or any of the respective further transcriptional regulatory states is present in said cell, wherein said output RNA comprises a sequence corresponding to said output sequence.

Abstract: The present invention relates to wearable device (1) adapted to detect contacts of fingers (F) on a surface (S), and to identify the responsible finger. It comprises move sensors adapted to collect the vibrations resulting from the contact of the fingers on a surface. It comprises a memory comprising reference vibration profiles (T), corresponding to the impact of at least one finger (F) of a user (U) to a surface (S). A computing unit (32) is configured allows to identify the finger responsible for the impact sensed by the move sensors (10, 10a, 10b). The invention further relates to a manufacturing process of such a device and to a method of sensing the contact of a finger on a surface.