Abstract: The invention relates to a device (1) for detecting an analyte in a gas mixture or a liquid, comprising: (a) a polymer sorption filter (2) configured to separate methanol from ethanol; and/or to separate hydrogen and/or methane from interferants; and (b) means configured to detect (4) at least one of methanol, ethanol, hydrogen and methane. Furthermore, described is a method for detecting an analyte using the device and the use of the device.

Abstract: A technique for synthesizing a shape includes generating a first plurality of offset tokens based on a first shape code and a first plurality of position tokens, wherein the first shape code represents a variation of a canonical shape, and wherein the first plurality of position tokens represent a first plurality of positions on the canonical shape. The technique also includes generating a first plurality of offsets associated with the first plurality of positions on the canonical shape based on the first plurality of offset tokens. The technique further includes generating the shape based on the first plurality of offsets and the first plurality of positions.

Abstract: A computer-implemented method (200) of radiation events localizations is indicated for a pixelated radiation detector (10) having a scintillator array (24) of scintillator array elements (26) arranged in an (m)×(n) array, and an optical sensor array (28) of optical sensors (30) arranged in a (q)×(z) array and coupled to the scintillator array (24) in light sharing mode. The method includes the steps of sampling (72) spatial intensity distributions of scintillation photons emitted by the scintillator array (24) in response to multiple incident radiation events; performing a clustering analysis (76) based on the sampled spatial intensity distributions, to obtain clusters (84) of radiation events attributed to scintillator array elements (26), wherein the dimension of the sampled spatial intensity distributions correspond to the (q)×(z) dimensions of the optical sensor array (28), and determining the localization of the radiation events based on the clustering analysis (76).

Abstract: An optoelectronic device (20) includes thin film structures (56) disposed on a semiconductor substrate (54) and patterned to define components of an integrated drive circuit, which is configured to generate a drive signal. A back end of line (BEOL) stack (42) of alternating metal layers (44, 46) and dielectric layers (50) is disposed over the thin film structures. The metal layers include a modulator layer (48), which contains a plasmonic waveguide (36, 99, 105) and a plurality of electrodes (30, 32, 34, 96, 98, 106), which apply a modulation to surface plasmons polaritons (SPPs) propagating in the plasmonic waveguide in response to the drive signal. A plurality of interconnect layers are patterned to connect the thin film structures to the electrodes.

Abstract: In some embodiments, a method trains a first parameter of a differentiable proxy codec to encode source content based on a first loss between first compressed source content and second compressed source content that is output by a target codec. A pre-processor pre-processes a source image to output a pre-processed source image, the pre-processing being based on a second parameter. The differentiable proxy codec encodes the pre-processed source image into a compressed pre-processed source image based on the first parameter. The method determines a second loss between the source image and the compressed pre-processed source image and determines an adjustment to the first parameter based on the second loss. The adjustment is used to adjust the second parameter of the pre-processor based on the second loss.

Abstract: A terahertz device for detecting or emitting or for both detecting and emitting electromagnetic waves in the terahertz frequency range. The terahertz device comprises: a first waveguide branch and a second waveguide branch, the first and second waveguide branches being configured to allow optical signals to propagate through them, the first and second waveguide branches being nonlinear dielectric elements with a thickness of at most 500 micrometres; and an antenna arrangement comprising a set of antennas for capturing and/or emitting electromagnetic waves in the terahertz frequency range, the antennas being placed along at least one of the waveguide branches in an immediate vicinity of the respective waveguide branch and/or around the respective waveguide branch to at least partially enclose the respective waveguide branch in a respective antenna gap of the respective antenna.

Abstract: A system includes a computing platform having a hardware processor and a memory storing a software code and a neural network (NN) having multiple layers including a last activation layer and a loss layer. The hardware processor executes the software code to identify different combinations of layers for testing the NN, each combination including candidate function(s) for the last activation layer and candidate function(s) for the loss layer. For each different combination, the software code configures the NN based on the combination, inputs, into the configured NN, a training dataset including multiple data objects, receives, from the configured NN, a classification of the data objects, and generates a performance assessment for the combination based on the classification. The software code determines a preferred combination of layers for the NN including selected candidate functions for the last activation layer and the loss layer, based on a comparison of the performance assessments.

Abstract: The invention relates to a method for isolating a biomolecule. A liquid sample comprising the biomolecule is contacted with an electrically conductive surface. The surface carries a chemical modification facilitating retention of said biomolecule, or an electrical retention potential is applied to said surface. The biomolecule is released by applying a voltage to the surface. The invention further relates to a device comprising a chamber configured for receiving a liquid sample, wherein a first surface of said chamber is a working electrode formed by a high-surface, electrochemically active material embedded in a non-electrically conductive polymer matrix. The device further comprises a counter electrode and connections to a voltage source. The invention further relates to a device and method for loading an extracellular vesicle with cargo molecules.

Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

Abstract: The present invention relates to a mutant receptor-binding domain (mRBD) of a coronavirus (mRBD-CORONA) or a fragment thereof and mutant spike protein of the coronavirus (CORONA-mSpike) or a fragment thereof comprising the CORO-NA-mRBD or the fragment thereof. Furthermore, the present invention relates to a polypeptide or protein comprising the mRBD-CORONA or the fragment thereof or CORONA-mSpike or the fragment thereof and a nucleic acid comprising a nucleotide sequence encoding for the mRBD-CORONA or the fragment thereof or the CORONA-mSpike or the fragment thereof. Furthermore, the present invention relates to a vaccine composition comprising one or more CORONA-mRBDs or fragments thereof, one or more CORONA-mSpikes, one or more polypeptides or proteins and/or one or more nucleic acids according to the present invention.

Abstract: A patch for detecting by at least one non-invasive imaging technique a leak of a biological fluid at an application site, wherein the patch includes either a layer including one or more first portions containing a first gel, one or more second portions containing a second gel and at least one sensing component embedded within the first gel and/or the second gel, or a layer containing a hydrogel and at least one sensing component, such as aerogel particles, and xerogel particles, embedded within the hydrogel.

Abstract: Techniques are disclosed for training and applying a denoising model. The denoising model includes multiple specialized denoisers and a generalizer, each of which is a machine learning model. The specialized denoisers are trained to denoise images associated with specific ranges of noise parameters. The generalizer is trained to generate per-pixel denoising kernels for denoising images associated with arbitrary noise parameters using outputs of the specialized denoisers. Subsequent to training, a noisy image, such as a live-action image or a rendered image, can be denoised by inputting the noisy image into the specialized denoisers to obtain intermediate denoised images that are then input, along with the noisy image, into the generalizer to obtain per-pixel denoising kernels, which can be normalized and applied to denoise the noisy image.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: A self-expandable stent includes a folded cylindrical sheet wall, which is folded along axes parallel to the longitudinal axis of the sheet of the cylindrical wall creating three or more drop shaped loops having an inner diameter and an end portion where the sheet of the cylindrical wall contacts each other along an contact surface parallel to the longitudinal axis, wherein each of the at least three bending loops are rotated towards the end portion of an adjacent loop, wherein the end portion has a curvature describing a bending diameter. The improvement includes providing a stent within a fold and deploy structure being able to exert sufficient compression ratios as well as sufficient radial outward forces on the vessel wall, once deployed.

Abstract: A method for detecting and/or characterizing a ligand-target binding based on photochemically induced dynamic nuclear polarization (photo-CIDNP) enhanced NMR spectroscopy, comprising the steps: (a) irradiating a sample (A) comprising a photosensitizer and a ligand to excite the photosensitizer and induce dynamic nuclear polarization of the ligand by the photosensitizer, (b) recording an NMR spectrum of sample (A), repeating steps (a) and (b) with a sample comprising sample (A) and further comprising a target of interest, and (c) comparing the NMR spectra of samples (A) and (B) and detecting and/or characterizing a ligand-target binding based on at least one difference in the NMR spectra. The present invention further pertains to a device for conducting the method.

Abstract: Some implementations of the disclosure are directed to capturing facial training data for one or more subjects, the captured facial training data including each of the one or more subject's facial skin geometry tracked over a plurality of times and the subject's corresponding jaw poses for each of those plurality of times; and using the captured facial training data to create a model that provides a mapping from skin motion to jaw motion. Additional implementations of the disclosure are directed to determining a facial skin geometry of a subject; using a model that provides a mapping from skin motion to jaw motion to predict a motion of the subject's jaw from a rest pose given the facial skin geometry; and determining a jaw pose of the subject using the predicted motion of the subject's jaw.

Abstract: A system (1) for measuring the optical activity of a sample (2) comprises at least one frequency modulation device (3), at least one synchronization device (4), and at least one detection device (5). The frequency modulation device (3) is configured to modulate a frequency of incident electromagnetic radiation being emitted from a sample (2) and/or being irradiated on to a sample (2) with at least one frequency modulation signal (Sf). The synchronization device (4) is configured to receive the at least one frequency modulation signal (Sf) and to emit at least one detection modulation signal (Sd) being synchronized with the at least one frequency modulation signal (Sf). The system (1) is configured such that the detection device (5) detects the electromagnetic radiation (EMs) in synchronization with the detection modulation signal (Sd).

Abstract: A system processing hardware executes a machine learning (ML) model-based video compression encoder to receive uncompressed video content and corresponding motion compensated video content, compare the uncompressed and motion compensated video content to identify an image space residual, transform the image space residual to a latent space representation of the uncompressed video content, and transform, using a trained image compression ML model, the motion compensated video content to a latent space representation of the motion compensated video content.

Abstract: Various embodiments set forth systems and techniques for changing a face within an image. The techniques include receiving a first image including a face associated with a first facial identity; generating, via a machine learning model, at least a first texture map and a first position map based on the first image; rendering a second image including a face associated with a second facial identity based on the first texture map and the first position map, wherein the second facial identity is different from the first facial identity.

Abstract: A device for arrangement on a body comprising an essentially rotation-symmetric portion. The device comprises at least one interface that comprises two clamps with at least one pivot axis, each clamp comprising a clamp tip, the respective clamp tip being arranged opposite of the at least one pivot axis and the pivot axis being arranged fixed in relation to a base structure comprised by the device. The clamps are configured to be pivoted around the at least one pivot axis between a first position and a second position, respectively, wherein in the first position, the clamp tips are spaced further from each other than in the second position. A support structure is arranged between the clamps. A support rope system has at least one support rope, with at least one support rope of the rope system being connected to a tensioning element fixed with respect to the base structure.