Patents Assigned to ETH Zurich
  • Publication number: 20190183800
    Abstract: The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 20, 2019
    Applicant: ETH Zurich
    Inventors: Jean-Christophe Leroux, Simon Matoori, Aaron Christoph Schmidt
  • Patent number: 10325346
    Abstract: An image processor inputs a first image and outputs a downscaled second image by upscaling the second image to a third image, wherein the third image is substantially the same size as the first image size with a third resolution, associating pixels in the second image with a corresponding group of pixels from the third set of pixels, sampling a first image area at a first location of the first set of pixels to generate a first image sample, sampling a second image area of the third set of pixels to generate a second image sample, measuring similarity between the image areas, generating a perceptual image value, recursively adjusting values of third set of pixels until the image perception value matches a perceptual standard value, and adjusting pixel values in the second image to a representative pixel value of each of the corresponding group of pixels.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: June 18, 2019
    Assignee: ETH-Zurich
    Inventors: Ahmet Cengiz Öztireli, Markus Gross
  • Publication number: 20190175627
    Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 13, 2019
    Applicants: ETH Zurich, UNIVERSITAT BERN
    Inventors: Mattias IVARSSON, Bastien CASTAGNER, Jean-Christophe LEROUX, Andreas PASCH
  • Patent number: 10319080
    Abstract: Enhanced removing of noise and outliers from one or more point sets generated by image-based 3D reconstruction techniques is provided. In accordance with the disclosure, input images and corresponding depth maps can be used to remove pixels that are geometrically and/or photometrically inconsistent with the colored surface implied by the input images. This allows standard surface reconstruction methods (such as Poisson surface reconstruction) to perform less smoothing and thus achieve higher quality surfaces with more features. In some implementations, the enhanced point-cloud noise removal in accordance with the disclosure can include computing per-view depth maps, and detecting and removing noisy points and outliers from each per-view point cloud by checking if points are consistent with the surface implied by the other input views.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: June 11, 2019
    Assignees: DISNEY ENTERPRISES, INC., ETH ZÜRICH (EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH)
    Inventors: Changil Kim, Olga Sorkine-Hornung, Christopher Schroers, Henning Zimmer, Katja Wolff, Mario Botsch, Alexander Sorkine-Hornung
  • Patent number: 10319576
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 11, 2019
    Assignees: ETH ZÜRICH, PAUL SCHERRER INSTITUT
    Inventors: Detlef Günther, Daniel Grolimund, Hao Wang
  • Patent number: 10308349
    Abstract: According to a first aspect of the invention, there is provided a method for operating a multicopter experiencing a failure during flight, the multicopter comprising a body, and at least four effectors attached to the body, each operable to produce both a torque and a thrust force which can cause the multicopter to fly when not experiencing said failure.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 4, 2019
    Assignee: ETH Zurich
    Inventors: Mark W. Mueller, Sergei Lupashin, Raffaello D'Andrea, Markus Waibel
  • Publication number: 20190160202
    Abstract: The invention relates to a process for forming a hyaluronan hydrogel, comprising the steps of a. providing a hyaluronan donor peptide conjugate and a hyaluronan acceptor peptide conjugate each represented by a general formula I, wherein 10% of R1 moieties are represented by a general formula II, wherein L is a 2 to 6 atom linker moiety and Pep is a transglutaminase donor or acceptor peptide, and the rest of R1 moieties are represented by —COOH. b. adding a factor XIII polypeptide and a thrombin polypeptide, or a factor XIIIa polypeptide. The invention further relates to compositions and hydrogels characterized by the depicted chemistry.
    Type: Application
    Filed: May 4, 2017
    Publication date: May 30, 2019
    Applicant: ETH ZÜRICH
    Inventors: Nicolas BROGUIERE, Emma CAVALLI, Marcy ZENOBI-WONG
  • Publication number: 20190160658
    Abstract: A joint unit, in particular a joint unit of a robot, a joint system, a robot for manipulation and/or transportation, in particular for transportation of an object, a robotic exoskeleton system and a method for manipulation and/or transportation, in particular for transportation of an object, in particular for moving a body. The joint unit has a rotary drive, a gear, at least one spring element and a joint output. The gear has a gear input and a gear output, wherein the gear input is mechanically coupled to the rotary drive and suitable for transformation of the torque provided by the rotary drive. The spring element is mechanically coupled to the gear output and suitable for at least partial storing of the torque provided by the gear output and/or of the torque provided by an external load applied to the joint unit.
    Type: Application
    Filed: July 25, 2017
    Publication date: May 30, 2019
    Applicant: ETH ZURICH
    Inventors: Marco HUTTER, Karen BODIE, Andreas LAUBER, Jemin HWANGBO
  • Patent number: 10306742
    Abstract: The invention relates to a droplet dispensing device (4) comprising a reservoir (9) for containing a liquid medium (10), an outlet (11) for dispensing droplets of said liquid medium (10) from said reservoir (9), an actuation means (12) for generating and transmitting a mechanical oscillation at an excitation frequency, and a resonant structure comprising a piston (15) coupled to said actuation means (12) for transmitting said mechanical oscillation to the liquid medium (10) contained in said reservoir (9) such that droplets are formed from said liquid medium (10), wherein a resonance frequency of said resonant structure is sufficiently close to said excitation frequency, such that resonance occurs. The invention further relates to a UV or X-ray light source, comprising a droplet dispensing device (4) according to the invention, and a method for providing a stream, in particular a monodisperse stream, of droplets by means of the droplet dispensing device (4).
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: May 28, 2019
    Assignee: ETH Zurich
    Inventors: Alexander Sanders, Bob Rollinger, Reza Abhari
  • Patent number: 10302420
    Abstract: The present invention relates to a method for detecting and reconstructing a surface illuminated with spatially structured light such that the light illuminates an area of the surface from which the light is reflected back. The light includes a temporarily varying intensity in the form of successive light modulation patterns. The back-reflected light is detected by an optical sensor including a plurality of pixels. A pixel coordinate is associated to each pixel and each pixel generated a photocurrent proportional to the intensity of the light impinging on a respective pixel, computes a signal related to a photocurrent, and each pixel outputs an address-event merely when a respective signal due to the light impinging on the respective pixel increases by an amount larger than a first threshold or decreases by an amount larger than a second threshold since a last address-event from the respective pixel.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: May 28, 2019
    Assignees: Universitat Zurich, Eth Zurich
    Inventors: Christian Brandli, Tobias Delbruck, Markus Andreas Hopflinger, Marco Hutter, Thomas Albert Mantel
  • Patent number: 10295507
    Abstract: A method to measure the vibrational characteristics of an oscillating system (1) uses a control system (6, 7a, 7b, 7c). The oscillating system comprises a resonator, at least one vibration exciter and at least one sensor. The resonator is excited by the vibration exciter, and the motion of the resonator is measured by the sensor. The control system uses the sensor to control the motion of the resonator by the vibration exciter. The motion of the resonator is a superposition of at least two harmonic motions, and the control system comprises at least two subcontrollers (7a, 7b, 7c). Each harmonic motion is controlled independently by one of the subcontrollers. The harmonic motions are controlled by the subcontrollers simultaneously. A corresponding device is also disclosed.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 21, 2019
    Assignee: ETH ZURICH
    Inventors: Jurg Dual, Tobias Brack, Robin Vujanic
  • Patent number: 10295546
    Abstract: A Method for the detection of the conformational state of a protein contained in a complex mixture of further proteins and/or other biomolecules, is proposed as well as assays for such a method. The method comprises the following steps: (1) Limited proteolysis of the complex mixture under a condition where the protein is in the conformational state to be detected leading to a first fragment sample; (2) Denaturation of the first fragment sample to a denaturated first fragment sample; (3) Complete fragmentation of the denaturated first fragment sample in a digestion step to a completely fragmented sample; and (4) Analytical analysis of the completely fragmented sample for the determination of fragments characteristic of having been the result both the limited proteolysis of step 1 as well as of the complete fragmentation in the digestion step 3. for the determination of the conformational state.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: May 21, 2019
    Assignee: ETH ZURICH
    Inventors: Paola Picotti, Yuehan Feng, Giorgia De Franceschi
  • Patent number: 10297065
    Abstract: Methods, systems, and computer-readable memory are provided for determining time-varying anatomical and physiological tissue characteristics of an animation rig. For example, shape and material properties are defined for a plurality of sample configurations of the animation rig. The shape and material properties are associated with the plurality of sample configurations. An animation of the animation rig is obtained, and one or more configurations of the animation rig are determined for one or more frames of the animation. The determined one or more configurations include shape and material properties, and are determined using one or more sample configurations of the animation rig. A simulation of the animation rig is performed using the determined one or more configurations. Performing the simulation includes computing physical effects for addition to the animation of the animation rig.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: May 21, 2019
    Assignees: DISNEY ENTERPRISES, INC., ETH ZÜRICH (EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH)
    Inventors: Yeara Kozlov, Bernhard Thomaszewski, Thabo Beeler, Derek Bradley, Moritz Bächer, Markus Gross
  • Patent number: 10287589
    Abstract: Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of blood glucose level, the reduction of gluceoneogenesis, the improvement of insulin resistance and the reduction of plasma cholesterol level. In certain embodiments, the methods comprise inhibiting the activity of miR-103. In certain embodiments, the methods comprise inhibiting the activity of miR-107. In certain embodiments, the activity of both miR-103 and miR-107 is inhibited. In certain embodiments, such methods comprise administering a compound comprising an oligonucleotide targeted to a microRNA.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: May 14, 2019
    Assignee: ETH Zurich
    Inventors: Markus Stoffel, Mirko Trajkovski
  • Publication number: 20190126036
    Abstract: Systems and methods for applying a pulsed electromagnetic fields. A system for applying a pulsed electromagnetic field (PEMF) to a cell, comprising: a sensor for obtaining a characteristic of the cell; a memory module having stored therein a plurality of characteristics and PEMF efficacy window data, each characteristic having its corresponding PEMF efficacy window data; a pulse generator coupled to a set of PEMF coils and configured to generate an output of electrical pulses to drive the set of PEMF coils; and a controller in communication with the sensor, the memory module and the pulse generator, wherein the controller is configured to: retrieve, from the memory module, the PEMF efficacy window data that corresponds to the characteristic of the cell obtained by the sensor; and control the output of the pulse generator based on the retrieved PEMF efficacy window data such that the set of PEMF coils apply a PEMF in accordance with the PEMF efficacy window data.
    Type: Application
    Filed: May 5, 2016
    Publication date: May 2, 2019
    Applicants: National University of Singapore, National University of Singapore, ETH Zurich, ETH Zurich
    Inventors: Alfredo Franco-Obregon, Chuen Neng Lee, Wee Chuan Melvin Loh, Jürg Hans Fröhlich, Christian Beyer, Tien Min David Lai
  • Publication number: 20190098370
    Abstract: The invention relates to systems and methods for manipulating non-linearly connected transmedia content, in particular for creating, processing and/or managing non-linearly connected transmedia content and for tracking content creation and attributing transmedia content to one or more creators. Specifically, the invention involves creating a transmedia content data item by a first user and storing the transmedia content data item in a data store, along with a record indicating an association between the first user and the transmedia content data item; creating an ordered group of transmedia content data items by a second user, the ordered group comprising a pointer to the transmedia content data item of the first user; and storing the ordered group and a record associating both the first user and the second user with the ordered group in the data store.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 28, 2019
    Applicants: DISNEY ENTERPRISES, INC., ETH Zürich (Eidgenössische Technische Hochschule Zürich)
    Inventors: Rebekkah Laeuchli, Sasha Schriber, Stephan Veen, Markus Gross, Isabel Simo, Max Grosse
  • Publication number: 20190096094
    Abstract: The present disclosure relates to an apparatus, system and method for processing transmedia content data. More specifically, the disclosure provides for identifying and inserting one item of media content within another item of media content, e.g. inserting a video within a video, such that the first item of media content appears as part of the second item. The invention involves analysing a first visual media item to identify one or more spatial locations to insert the second visual media item within the image data of the first visual media item, detecting characteristics of the one or more identified spatial locations, transforming the second visual media item according to the detected characteristics and combining the first visual media item and second visual media item by inserting the transformed second visual media item into the first visual media item at the one or more identified spatial locations.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 28, 2019
    Applicants: DISNEY ENTERPRISES, INC., ETH Zürich (Eidgenössische Technische Hochschule Zürich)
    Inventors: Alex Sorkine-Hornung, Simone Meier, Jean-Charles Bazin, Sasha Schriber, Markus Gross, Oliver Wang
  • Publication number: 20190095446
    Abstract: The invention relates to systems and methods for navigating, outputting and displaying non-linearly connected groups of transmedia content. Specifically, the invention involves retrieving, from a database, an ordered group of transmedia content data objects comprising a plurality of transmedia content data objects and linking data, whereby each element of the linking data defines a directional link from one of the transmedia content data objects to another of the transmedia content data objects; generating a two-dimensional graph structure representing the ordered group of transmedia content data objects whereby each graph node corresponds to a transmedia content data object and each graph edge corresponds to an element of the linking data; and outputting the graph structure on a display screen.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 28, 2019
    Applicants: DISNEY ENTERPRISES, INC., ETH Zürich (Eidgenössische Technische Hochschule Zürich)
    Inventors: Rebekkah Laeuchli, Isabel Simo, Max Grosse, Markus Gross, Sasha Schriber, Maria Cabral, Merada Richter
  • Publication number: 20190095435
    Abstract: The present invention relates to systems and methods for manipulating non-linearly connected transmedia content, in particular for creating, processing and managing non-linearly connected transmedia content. The disclosure includes content creation modes and version control systems for non-linearly connected transmedia content data, in which individual transmedia content data items are connected to either other via directional linking data.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 28, 2019
    Applicants: DISNEY ENTERPRISES, INC., ETH Zürich (Eidgenössische Technische Hochschule Zürich)
    Inventors: Rebekkah Laeuchli, Isabel Simo, Max Grosse, Sasha Schriber, Markus Gross, Maria Cabral
  • Publication number: 20190077020
    Abstract: A mobile manufacturing device and a method for producing three-dimensional lattice or mesh structures, wherein the mobile manufacturing device is a mobile device adapted to move along a three-dimensional structure to be produced, in particular while performing both translation and rotation movements in three-dimensional space, and wherein the mobile manufacturing device includes a means for detection of its position relative to the dimensional structure to be produced, so that the mobile manufacturing device is able to produce the three-dimensional structure as an autonomous robot.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 14, 2019
    Applicant: ETH ZÜRICH
    Inventors: Norman Peter HACK, Nitish KUMAR, Jonas BUCHLI, Matthias KOHLER, Fabio Matteo GRAMAZIO