Patents Assigned to ETH Zurich
  • Publication number: 20210012512
    Abstract: Some implementations of the disclosure are directed to capturing facial training data for one or more subjects, the captured facial training data including each of the one or more subject's facial skin geometry tracked over a plurality of times and the subject's corresponding jaw poses for each of those plurality of times; and using the captured facial training data to create a model that provides a mapping from skin motion to jaw motion. Additional implementations of the disclosure are directed to determining a facial skin geometry of a subject; using a model that provides a mapping from skin motion to jaw motion to predict a motion of the subject's jaw from a rest pose given the facial skin geometry; and determining a jaw pose of the subject using the predicted motion of the subject's jaw.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 14, 2021
    Applicants: Disney Enterprises, Inc., ETH Zürich (Eidgenössische Technische Hochschule Zürich)
    Inventors: Dominik Thabo Beeler, Derek Edward Bradley, Gaspard Zoss
  • Patent number: 10889603
    Abstract: A versatile, highly efficient process for the preparation of acylphosphines such as mono- and bisacylphosphines via reaction of phosphines (PH3 and higher homologues) or silylated phosphines with acylhalides in the presence of at least one lewis acid. Further a novel acyl phosphines obtainable by the process.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: January 12, 2021
    Assignees: ETH ZÜRICH, THE UNIVERSITY OF BRISTOL
    Inventors: Hansjörg Grützmacher, Paul Gerard Pringle, Mark Bispinghoff
  • Patent number: 10887581
    Abstract: The present disclosure relates to techniques for reconstructing an object in three dimensions that is captured in a set of two-dimensional images. The object is reconstructed in three dimensions by computing depth values for edges of the object in the set of two-dimensional images. The set of two-dimensional images may be samples of a light field surrounding the object. The depth values may be computed by exploiting local gradient information in the set of two-dimensional images. After computing the depth values for the edges, depth values between the edges may be determined by identifying types of the edges (e.g., a texture edge, a silhouette edge, or other type of edge). Then, the depth values from the set of two-dimensional images may be aggregated in a three-dimensional space using a voting scheme, allowing the reconstruction of the object in three dimensions.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: January 5, 2021
    Assignees: DISNEY ENTERPRISES, INC., ETH ZÜRICH (EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH)
    Inventors: Kaan Yücer, Changil Kim, Alexander Sorkine-Hornung, Olga Sorkine-Hornung
  • Patent number: 10882884
    Abstract: The present invention relates to chiral phosphoramidites represented by formula (Ia) or formula (Ib) as novel monomers for the synthesis of stereodefined phosphorothioate MOE oligonucleotides. Furthermore, the present invention relates to a method for synthesizing stereodefined phosphorothioate MOE oligonucleotides using said novel chiral phosphoramidites.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: January 5, 2021
    Assignee: ETH ZURICH
    Inventors: Jonathan Hall, Meiling Li
  • Patent number: 10885708
    Abstract: An automated costume augmentation system includes a computing platform having a hardware processor and a system memory storing a software code. The hardware processor executes the software code to provide an image including a posed figure to an artificial neural network (ANN), receive from the ANN a 2D skeleton data including joint positions corresponding to the posed figure, and determine a 3D pose corresponding to the posed figure using an optimization algorithm applied to the skeleton data. The software code further identifies one or more proportion(s) of the posed figure based on the skeleton data, determines bone directions corresponding to the posed figure using another optimization algorithm applied to the 3D pose, parameterizes a costume for the posed figure based on the 3D pose, the proportion(s), and the bone directions, and outputs an enhanced image including the posed figure augmented with the fitted costume for rendering on a display.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: January 5, 2021
    Assignees: Disney Enterprises, Inc., ETH ZURICH
    Inventors: Martin Guay, Gökcen Cimen, Christoph Maurhofer, Mattia Ryffel, Robert W. Sumner
  • Publication number: 20200399401
    Abstract: The present invention relates to the field of antibodies useful in therapy and diagnosis. It specifically discloses bioconjugates comprising one or more antibodies bound to functionalized, magnetic nanoparticles. These bioconjugates are useful in cancer therapy, particularly for removing circulating tumor cells. The invention further pertains to specific functionalized, magnetic nanoparticles and to the manufacturing of such bioconjugates and such functionalized, magnetic nanoparticles.
    Type: Application
    Filed: February 25, 2019
    Publication date: December 24, 2020
    Applicants: Universität Zürich, ETH Zurich
    Inventors: Antoine Florent Herzog, Wendelin Jan Stark, Martin Zeltner, Beatrice Beck-Schimmer, Anja Zabel
  • Patent number: 10865516
    Abstract: The invention relates to manufacturing processes for waterproof and breathable porous polymer membranes by coating a substrate with a dispersion comprising polymer, coated particles and diluent and removing the particles by dissolution, wherein the particles are made of organic salts, metal salts or metal oxides and the coating material is selected from carboxylic acids and alkoxy silanes. The invention further relates to dispersions to obtain such membranes, to polymer membranes obtained, to shaped articles containing such membranes; to the use of such membranes, shaped articles and intermediates.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: December 15, 2020
    Assignee: ETH Zurich
    Inventors: Wendelin Jan Stark, Mario Stucki
  • Patent number: 10865408
    Abstract: The invention relates to a chimeric antigen-receptor polypeptide heterodimer comprising two polypeptides, wherein the first contains an extracellular part of the major histocompatibility complex I alpha chain and the second contains a 32-microglobulin domain, or the first contains an extracellular part of the major histocompatibility complex II alpha chain and the second contains a major histocompatibility complex II beta chain. One of the polypeptides further contains a transmembrane domain, a hinge region and an intracellular domain of the T cell receptor alpha chain and the other one contains a transmembrane domain, a hinge region and an intracellular domain of the T cell receptor beta chain, and additionally an antigen-peptide covalently linked to said extracellular MHC domain. The invention further relates to a method for the identification of a TCR recognizable peptide sequence making use of the heterodimer of the invention.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: December 15, 2020
    Assignee: ETH Zurich
    Inventors: Jan Kisielow, Franz-Josef Obermair, Manfred Kopf
  • Publication number: 20200363484
    Abstract: A method for generating an image data set of an image area located in a measurement volume of a magnetic resonance system comprising a gradient system and an RF transmission/reception system, comprises the following method steps: —reading out k-space corresponding to the imaging area, by: (a) activating a frequency encoding gradient in a predetermined spatial direction and with a predetermined strength G0 by means of said gradient system, (b) after the activated frequency encoding gradient achieves its strength G0, radiating a non-slice-selective RF excitation pulse by means of said RF transmission/reception system, (c) after a transmit-receive switch time ?tTR following the radiated excitation pulse, acquiring FID signals with said RF transmission/reception system and storing said FID signals as raw data points in k-space along a radial k-space trajectory that is predetermined by the direction and strength G0 of the frequency encoding gradient, (d) repeating (a) through (c) with respectively different freque
    Type: Application
    Filed: October 8, 2018
    Publication date: November 19, 2020
    Applicants: ETH Zurich, UNIVERSITAET ZUERICH
    Inventors: Romain FROIDEVAUX, Markus WEIGER
  • Patent number: 10818080
    Abstract: According to one implementation, a system includes a computing platform having a hardware processor and a system memory storing a software code including multiple artificial neural networks (ANNs). The hardware processor executes the software code to partition a multi-dimensional input vector into a first vector data and a second vector data, and to transform the second vector data using a first piecewise-polynomial transformation parameterized by one of the ANNs, based on the first vector data, to produce a transformed second vector data. The hardware processor further executes the software code to transform the first vector data using a second piecewise-polynomial transformation parameterized by another of the ANNs, based on the transformed second vector data, to produce a transformed first vector data, and to determine a multi-dimensional output vector based on an output from the plurality of ANNs.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: October 27, 2020
    Assignees: Disney Enterprises, Inc., ETH Zürich (EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH)
    Inventors: Thomas Muller, Brian McWilliams, Fabrice Pierre Armand Rousselle, Jan Novak
  • Publication number: 20200325468
    Abstract: According to a first aspect of the invention, a method for the generation of a cell line is provided, comprising the steps of (a) providing a plurality of mammalian B cells, wherein each of the plurality of B cells comprises a transgenic genomic DNA sequence encoding a marker protein inserted into an endogenous immunoglobulin locus comprised in said B cell, and wherein the transgenic genomic DNA sequence is amenable to cleavage by a site directed nuclease, particularly Cas9; (b) replacing the transgenic genomic DNA sequence encoding a marker protein with a second transgenic DNA sequence encoding a protein of interest; (c) sorting B cells based on the presence or absence of the marker protein; and (d) collecting B cells in which the marker protein is absent.
    Type: Application
    Filed: March 17, 2017
    Publication date: October 15, 2020
    Applicant: ETH ZURICH
    Inventors: Sai REDDY, William KELTON, Cristina PAROLA, Derek MASON, Mark POGSON
  • Patent number: 10804090
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: October 13, 2020
    Assignees: ETH ZÜRICH, PAUL SCHERRER INSTITUT
    Inventors: Detlef Günther, Daniel Grolimund, Hao Wang
  • Patent number: 10793921
    Abstract: The present invention is directed to a cellular biosensor system comprising (A) a repressor module comprising one or more genes, which in their cumulative gene action exert repressing and/or inhibitory effect(s) on (B), an output module comprising at least one gene comprising at least one output sequence generating one or more output signals (i) in the absence of repressing and/or inhibitory effect(s) of the repressor module (A) and (ii) in the presence of at least one recombinase expressed by (C), a recombinase module comprising at least one gene comprising at least one sequence encoding a site-specific recombinase that enables gene rearrangement in the output module resulting in one or more output signals in the absence of repressing and/or inhibitory effect(s) of the repressor module, wherein the repressing and/or inhibitory effects of the repressor module are controlled by one or more inputs that negatively affect the repressing and/or inhibitory effects of the repressor module (A).
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 6, 2020
    Assignee: ETH ZURICH
    Inventors: Yaakov Benenson, Nicolas Lapique
  • Patent number: 10796414
    Abstract: Supervised machine learning using convolutional neural network (CNN) is applied to denoising images rendered by MC path tracing. The input image data may include pixel color and its variance, as well as a set of auxiliary buffers that encode scene information (e.g., surface normal, albedo, depth, and their corresponding variances). In some embodiments, a CNN directly predicts the final denoised pixel value as a highly non-linear combination of the input features. In some other embodiments, a kernel-prediction neural network uses a CNN to estimate the local weighting kernels, which are used to compute each denoised pixel from its neighbors. In some embodiments, the input image can be decomposed into diffuse and specular components. The diffuse and specular components are then independently preprocessed, filtered, and postprocessed, before recombining them to obtain a final denoised image.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: October 6, 2020
    Assignees: Disney Enterprises, Inc., ETH Zürich (Eidgenössische Technische Hochschule Zürich)
    Inventors: Thijs Vogels, Jan Novák, Fabrice Rousselle, Brian McWilliams
  • Publication number: 20200287353
    Abstract: A waveguide heterostructure for a semiconductor laser with an active part, comprising an active region layer depending of the type of semiconductor used, which is sandwiched between an electrode layer and a substrate, usable for dispersion compensation in a semiconductor laser frequency comb setup, an optical frequency comb setup and a manufacturing method.
    Type: Application
    Filed: September 27, 2018
    Publication date: September 10, 2020
    Applicant: ETH Zürich
    Inventors: Jérôme FAIST, Yves BIDAUX, Filippos KAPSALIDIS
  • Patent number: 10743397
    Abstract: The invention relates to a method for generating electromagnetic radiation by a laser-produced plasma, wherein a target comprising a target material is provided, at least one pulse sequence is directed to said target, wherein the pulse sequence comprises four to nine conditioning laser pulses, wherein time intervals between subsequent conditioning laser pulses are 200 ns or less, and a main laser pulse is directed to said target along a first axis, such that a radiation-emitting plasma is formed from at least a part of said target material. The invention further relates to a device for generating electromagnetic radiation by means of a laser-produced plasma comprising a dispensing device and at least one laser source, wherein the device is configured such that at least one pulse sequence comprising four to nine conditioning laser pulses and a main laser pulse can be generated by the at least one laser source.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: August 11, 2020
    Assignee: ETH ZÜRICH
    Inventors: Duane Edward Hudgins, Reza Shokrollah Abhari
  • Publication number: 20200247837
    Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.
    Type: Application
    Filed: April 20, 2020
    Publication date: August 6, 2020
    Applicants: ETH Zurich, UNIVERSITAT BERN
    Inventors: Mattias IVARSSON, Bastien CASTAGNER, Jean-Christophe LEROUX, Andreas PASCH
  • Patent number: 10718782
    Abstract: The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 21, 2020
    Assignees: Shiseido Company, Ltd., ETH Zurich
    Inventors: Yuzo Yoshida, Kentaro Kajiya, Michael Detmar
  • Patent number: 10713832
    Abstract: A method of identifying locations in a virtual environment where a motion sequence can be performed by an animated character may include accessing the motion sequence for the animated character, identifying a plurality of contact locations in the motion sequence where the animated character contacts surfaces in virtual environments, accessing the virtual environment comprising a plurality of surfaces, and identifying the locations in the virtual environment where the motion sequence can be performed by the animated character by identifying surfaces in the plurality of surfaces that match the plurality of contact locations.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 14, 2020
    Assignees: Disney Enterprises, Inc., ETH Zürich
    Inventors: Robert Sumner, Xu Xianghao, Stelian Coros, Mubbasir Turab Kapadia
  • Publication number: 20200208346
    Abstract: The present invention provides a method for obtaining densified material comprising the steps of a. providing lignocellulosic material, b. delignification of the lignocellulosic material providing a delignified material, wherein the delignification step is performed in such a way that the lignin of the lignocellulosic material is almost completely removed and wherein the structural integrity of the lignocellulosic material is maintained in the delignified material, c. densification of the delignified material providing a densified material. Furthermore, a densified material is provided. The fibers and fibrils are maintained in the structural directionality of the raw material and that the cellulosic material is whitish.
    Type: Application
    Filed: April 12, 2018
    Publication date: July 2, 2020
    Applicants: ETH ZURICH, EMPA, EIDGENÖSSISCHE MATERIALPRÜFUNGS- UND FORSCHUNGSANSTALT
    Inventors: Thomas SCHNIDER, Ingo BURGERT, Jana SEGMEHL, Tobias KEPLINGER