Abstract: The invention relates to a method for isolating a biomolecule. A liquid sample comprising the biomolecule is contacted with an electrically conductive surface. The surface carries a chemical modification facilitating retention of said biomolecule, or an electrical retention potential is applied to said surface. The biomolecule is released by applying a voltage to the surface. The invention further relates to a device comprising a chamber configured for receiving a liquid sample, wherein a first surface of said chamber is a working electrode formed by a high-surface, electrochemically active material embedded in a non-electrically conductive polymer matrix. The device further comprises a counter electrode and connections to a voltage source. The invention further relates to a device and method for loading an extracellular vesicle with cargo molecules.

Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

Abstract: The present invention relates to a mutant receptor-binding domain (mRBD) of a coronavirus (mRBD-CORONA) or a fragment thereof and mutant spike protein of the coronavirus (CORONA-mSpike) or a fragment thereof comprising the CORO-NA-mRBD or the fragment thereof. Furthermore, the present invention relates to a polypeptide or protein comprising the mRBD-CORONA or the fragment thereof or CORONA-mSpike or the fragment thereof and a nucleic acid comprising a nucleotide sequence encoding for the mRBD-CORONA or the fragment thereof or the CORONA-mSpike or the fragment thereof. Furthermore, the present invention relates to a vaccine composition comprising one or more CORONA-mRBDs or fragments thereof, one or more CORONA-mSpikes, one or more polypeptides or proteins and/or one or more nucleic acids according to the present invention.

Abstract: A patch for detecting by at least one non-invasive imaging technique a leak of a biological fluid at an application site, wherein the patch includes either a layer including one or more first portions containing a first gel, one or more second portions containing a second gel and at least one sensing component embedded within the first gel and/or the second gel, or a layer containing a hydrogel and at least one sensing component, such as aerogel particles, and xerogel particles, embedded within the hydrogel.

Abstract: Techniques are disclosed for training and applying a denoising model. The denoising model includes multiple specialized denoisers and a generalizer, each of which is a machine learning model. The specialized denoisers are trained to denoise images associated with specific ranges of noise parameters. The generalizer is trained to generate per-pixel denoising kernels for denoising images associated with arbitrary noise parameters using outputs of the specialized denoisers. Subsequent to training, a noisy image, such as a live-action image or a rendered image, can be denoised by inputting the noisy image into the specialized denoisers to obtain intermediate denoised images that are then input, along with the noisy image, into the generalizer to obtain per-pixel denoising kernels, which can be normalized and applied to denoise the noisy image.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: A self-expandable stent includes a folded cylindrical sheet wall, which is folded along axes parallel to the longitudinal axis of the sheet of the cylindrical wall creating three or more drop shaped loops having an inner diameter and an end portion where the sheet of the cylindrical wall contacts each other along an contact surface parallel to the longitudinal axis, wherein each of the at least three bending loops are rotated towards the end portion of an adjacent loop, wherein the end portion has a curvature describing a bending diameter. The improvement includes providing a stent within a fold and deploy structure being able to exert sufficient compression ratios as well as sufficient radial outward forces on the vessel wall, once deployed.

Abstract: A method for detecting and/or characterizing a ligand-target binding based on photochemically induced dynamic nuclear polarization (photo-CIDNP) enhanced NMR spectroscopy, comprising the steps: (a) irradiating a sample (A) comprising a photosensitizer and a ligand to excite the photosensitizer and induce dynamic nuclear polarization of the ligand by the photosensitizer, (b) recording an NMR spectrum of sample (A), repeating steps (a) and (b) with a sample comprising sample (A) and further comprising a target of interest, and (c) comparing the NMR spectra of samples (A) and (B) and detecting and/or characterizing a ligand-target binding based on at least one difference in the NMR spectra. The present invention further pertains to a device for conducting the method.

Abstract: A system (1) for measuring the optical activity of a sample (2) comprises at least one frequency modulation device (3), at least one synchronization device (4), and at least one detection device (5). The frequency modulation device (3) is configured to modulate a frequency of incident electromagnetic radiation being emitted from a sample (2) and/or being irradiated on to a sample (2) with at least one frequency modulation signal (Sf). The synchronization device (4) is configured to receive the at least one frequency modulation signal (Sf) and to emit at least one detection modulation signal (Sd) being synchronized with the at least one frequency modulation signal (Sf). The system (1) is configured such that the detection device (5) detects the electromagnetic radiation (EMs) in synchronization with the detection modulation signal (Sd).

Abstract: A system processing hardware executes a machine learning (ML) model-based video compression encoder to receive uncompressed video content and corresponding motion compensated video content, compare the uncompressed and motion compensated video content to identify an image space residual, transform the image space residual to a latent space representation of the uncompressed video content, and transform, using a trained image compression ML model, the motion compensated video content to a latent space representation of the motion compensated video content.

Abstract: Some implementations of the disclosure are directed to capturing facial training data for one or more subjects, the captured facial training data including each of the one or more subject's facial skin geometry tracked over a plurality of times and the subject's corresponding jaw poses for each of those plurality of times; and using the captured facial training data to create a model that provides a mapping from skin motion to jaw motion. Additional implementations of the disclosure are directed to determining a facial skin geometry of a subject; using a model that provides a mapping from skin motion to jaw motion to predict a motion of the subject's jaw from a rest pose given the facial skin geometry; and determining a jaw pose of the subject using the predicted motion of the subject's jaw.

Abstract: Various embodiments set forth systems and techniques for changing a face within an image. The techniques include receiving a first image including a face associated with a first facial identity; generating, via a machine learning model, at least a first texture map and a first position map based on the first image; rendering a second image including a face associated with a second facial identity based on the first texture map and the first position map, wherein the second facial identity is different from the first facial identity.

Abstract: A device for arrangement on a body comprising an essentially rotation-symmetric portion. The device comprises at least one interface that comprises two clamps with at least one pivot axis, each clamp comprising a clamp tip, the respective clamp tip being arranged opposite of the at least one pivot axis and the pivot axis being arranged fixed in relation to a base structure comprised by the device. The clamps are configured to be pivoted around the at least one pivot axis between a first position and a second position, respectively, wherein in the first position, the clamp tips are spaced further from each other than in the second position. A support structure is arranged between the clamps. A support rope system has at least one support rope, with at least one support rope of the rope system being connected to a tensioning element fixed with respect to the base structure.

Abstract: The present invention relates to a digital transaction between a sender (S) and a recipient (R), wherein the digital transaction is certified by a central bank (B), while preserving the privacy of the transaction (T). In particular the transaction (T) is based on a first sender serial number (SSNi) and a first receiver serial number, both signed by the central bank (B) and dedicated to the transaction. The transaction is in addition based on commitment to a value, which is encrypted with a blind factor (BTx) and involves sender zero-knowledge proof (zKs) and receiver zero-knowledge proof (zKr) so that the central bank (B) has no knowledge of the value of the transaction neither of the identity of the sender and the receiver. The present invention also relates to a system and to a digital currency allowing such a digital transaction.

Abstract: A kit of parts including two components, the first component being a patch including a non-degradable synthetic hydrogel and the second component being an impregnating fluid, which, upon in-situ polymerisation, anchors the patch on a tissue. The patch may include additional layers including sensing components or therapeutic components. In addition, the use of the kit of parts and the use of an impregnating fluid in surgery, in particular as suture or staple supports, e.g. suture or staple supports in the abdominal region such as intestinal anastomosis sites, or for sealing of artificial stoma.

Abstract: In some embodiments, a system includes a first component to extract temporal features from a current frame being coded and a previous frame of a video. A second component uses a first transformer to fuse spatial features from the current frame with the temporal features to generate spatio-temporal features as first output. A third component uses a second transformer to perform entropy coding using the first output and at least a portion of the temporal features to generate a second output. A fourth component uses a third transformer to reconstruct the current frame based on the first output that is processed using the second output and the temporal features.

Abstract: According to one implementation, an image compression system includes a computing platform having a hardware processor and a system memory storing a software code. The hardware processor executes the software code to receive an input image, transform the input image to a latent space representation of the input image, and quantize the latent space representation of the input image to produce multiple quantized latents. The hardware processor further executes the software code to encode the quantized latents using a probability density function of the latent space representation of the input image, to generate a bitstream, and convert the bitstream into an output image corresponding to the input image. The probability density function of the latent space representation of the input image is obtained based on a normalizing flow mapping of one of the input image or the latent space representation of the input image.

Abstract: In a method for analyzing cells, a sample fluid having a suspending medium and cells is fed to a microfluidic device having at least one cell processing unit having a trapping region, a reaction unit, and an outlet arrangement. The trapping region is delimited by at least an input valve and a sieve valve, in particular a v-type valve that is capable of retaining the cells while letting fluids pass. The method includes trapping cells in the trapping region, subsequently establishing a flow of a reaction fluid through the trapping region while the sieve valve assumes the open state, such that the reaction fluid transfers the trapped cells from the trapping region into the reaction unit, decomposing the transferred cells into cell fragments through a decomposition process, collecting the cell fragments in the outlet arrangement, and analyzing the cell fragments.

Abstract: The present invention relates to energy storage systems and reactors useful in such systems. Inventive reactors comprise a reaction vessel defining an inner volume and a compensation element, whereby said inner volume is filled with a fixed bed that is free of cavities and that comprises particles of formula (I), FeOx (I), where 0?x?1.5; said compensation element is adapted to adjust said inner volume. The reactors are inherently explosion proof and thus suited for domestic use. The systems are useful for compensating long-term fluctuations observed in production of renewable energy.

Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.