Abstract: A composition including a temperature sensitive biocompatible solder and at least one type of nanoparticles, characterized in that a first type of nanoparticles is a fluorescent nanothermometer, wherein the fluorescent nanothermometer exhibits an excitation maximum and temperature dependent emission spectrum each in the range of between 650 and 1350 nm. The composition can be used for laser tissue soldering.

Abstract: A push-pull device (10) comprises: a first waveguide (W1) arranged between its first and second electrode (S11, S12) and a second waveguide (W2) arranged between its first and a second electrode (S21, S22). Electrically conductive structures (T11, T12, T21, T22) extend away from one or more of the electrodes (S11, S12, S21, S22) for electrically connecting at least two of the electrodes (S11, S12, S21, S22). The waveguides (W1, W2) and the electrodes (S11, S12, S21, S22) originate from a pre-fabrication process. The waveguides (W1, W2) are poled by a poling (P) originating from a poling process.

Abstract: A perfusion loop assembly for ex vivo liver perfusion includes a pump providing perfusion fluid through a line branching at a branching point into a first branch line and a second branch line. The first branch line provides a first portion of the perfusion fluid to the hepatic artery of the liver, the first branch line coupled with a gas exchanger, where the first branch line includes a flow rate sensor and/or a pressure sensor. The second branch line provides a second portion of the perfusion fluid to the portal vein of the liver; the second branch line includes a valve for controlling flow of perfusion fluid into the portal vein. The second branch line includes a flow rate sensor and/or a pressure sensor. A liver chamber assembly holds the liver ex vivo, and an outlet line for the perfusion fluid connects the liver chamber assembly and the pump.

Abstract: Method for the detection of a conformational state of a protein being in a complex mixture of further proteins and other biomolecules, wherein the protein has been subjected to a condition inducing a structural change, including: limited proteolysis of the extract mixture under a condition in which the protein is in the original conformational state to be detected leading to a first fragment sample; directly followed by (2) removal of large peptides and proteins or other biomolecules from said first fragment sample to form an enriched fragment sample; (3) analytical analysis of the enriched fragment sample for the determination of fragments characteristic of having been the result of the limited proteolysis of (1) as well as remaining after the removal (2) for the determination of the conformational state of said at least one protein.

Abstract: One embodiment of the present invention sets forth a technique for generating actuation values based on a target shape such that the actuation values cause a simulator to output a simulated soft body that matches the target shape. The technique includes inputting a latent code that represents a target shape and a point on a geometric mesh into a first machine learning model. The technique further includes generating, via execution of the first machine learning model, one or more simulator control values that specify a deformation of the geometric mesh, where each of the simulator control values is based on the latent code and corresponds to the input point, and generating, via execution of the simulator, a simulated soft body based on the one or more simulator control values and the geometric mesh. The technique further includes causing the simulated soft body to be outputted to a computing device.

Abstract: The present invention provides additive manufacturing compositions, also referred as “inks” in the field of additive manufacturing, which can be fine-tuned with respect to porosity by varying the intensity of the photopolymerisation light source and which can further be used to obtain objects out of glasses, ceramics or glass-ceramics and their respective alloys.

Abstract: A device for electrically stimulating at least one nerve. The device comprises a bendable substrate configured to be arranged at least partially surrounding the nerve so as to define an inner surface of the substrate that faces an outer surface of the nerve. At least two electrodes, whereby at least one of the electrodes is a surface electrode and at least one of the electrodes is an intraneural electrode, each being arranged on the inner surface of the substrate. At least one surface electrode is configured to establish an electric connection with a part of the nerve on the outer surface of the nerve. At least one intraneural electrode is configured to penetrate the outer surface of the nerve to establish an electric connection with a part of the nerve within the nerve. A method for electrically stimulating at least one nerve is also provided.

Abstract: A technique for rendering an input geometry includes generating a first segmentation mask for a first input geometry and a first set of texture maps associated with one or more portions of the first input geometry. The technique also includes generating, via one or more neural networks, a first set of neural textures for the one or more portions of the first input geometry. The technique further includes rendering a first image corresponding to the first input geometry based on the first segmentation mask, the first set of texture maps, and the first set of neural textures.

Abstract: The present invention relates to the field of water treatment/fluoride removal and to materials/devices useful in such processes. Specifically, the invention provides for hybrid materials comprising amyloid fibrils and ZrO2; and to composite materials further comprising a support material. The invention further provides for the treatment of water using such hybrid or composite materials.

Abstract: The invention relates to a device (1) for detecting an analyte in a gas mixture or a liquid, comprising: (a) a polymer sorption filter (2) configured to separate methanol from ethanol; and/or to separate hydrogen and/or methane from interferants; and (b) means configured to detect (4) at least one of methanol, ethanol, hydrogen and methane. Furthermore, described is a method for detecting an analyte using the device and the use of the device.

Abstract: A technique for synthesizing a shape includes generating a first plurality of offset tokens based on a first shape code and a first plurality of position tokens, wherein the first shape code represents a variation of a canonical shape, and wherein the first plurality of position tokens represent a first plurality of positions on the canonical shape. The technique also includes generating a first plurality of offsets associated with the first plurality of positions on the canonical shape based on the first plurality of offset tokens. The technique further includes generating the shape based on the first plurality of offsets and the first plurality of positions.

Abstract: A computer-implemented method (200) of radiation events localizations is indicated for a pixelated radiation detector (10) having a scintillator array (24) of scintillator array elements (26) arranged in an (m)×(n) array, and an optical sensor array (28) of optical sensors (30) arranged in a (q)×(z) array and coupled to the scintillator array (24) in light sharing mode. The method includes the steps of sampling (72) spatial intensity distributions of scintillation photons emitted by the scintillator array (24) in response to multiple incident radiation events; performing a clustering analysis (76) based on the sampled spatial intensity distributions, to obtain clusters (84) of radiation events attributed to scintillator array elements (26), wherein the dimension of the sampled spatial intensity distributions correspond to the (q)×(z) dimensions of the optical sensor array (28), and determining the localization of the radiation events based on the clustering analysis (76).

Abstract: An optoelectronic device (20) includes thin film structures (56) disposed on a semiconductor substrate (54) and patterned to define components of an integrated drive circuit, which is configured to generate a drive signal. A back end of line (BEOL) stack (42) of alternating metal layers (44, 46) and dielectric layers (50) is disposed over the thin film structures. The metal layers include a modulator layer (48), which contains a plasmonic waveguide (36, 99, 105) and a plurality of electrodes (30, 32, 34, 96, 98, 106), which apply a modulation to surface plasmons polaritons (SPPs) propagating in the plasmonic waveguide in response to the drive signal. A plurality of interconnect layers are patterned to connect the thin film structures to the electrodes.

Abstract: In some embodiments, a method trains a first parameter of a differentiable proxy codec to encode source content based on a first loss between first compressed source content and second compressed source content that is output by a target codec. A pre-processor pre-processes a source image to output a pre-processed source image, the pre-processing being based on a second parameter. The differentiable proxy codec encodes the pre-processed source image into a compressed pre-processed source image based on the first parameter. The method determines a second loss between the source image and the compressed pre-processed source image and determines an adjustment to the first parameter based on the second loss. The adjustment is used to adjust the second parameter of the pre-processor based on the second loss.

Abstract: A terahertz device for detecting or emitting or for both detecting and emitting electromagnetic waves in the terahertz frequency range. The terahertz device comprises: a first waveguide branch and a second waveguide branch, the first and second waveguide branches being configured to allow optical signals to propagate through them, the first and second waveguide branches being nonlinear dielectric elements with a thickness of at most 500 micrometres; and an antenna arrangement comprising a set of antennas for capturing and/or emitting electromagnetic waves in the terahertz frequency range, the antennas being placed along at least one of the waveguide branches in an immediate vicinity of the respective waveguide branch and/or around the respective waveguide branch to at least partially enclose the respective waveguide branch in a respective antenna gap of the respective antenna.

Abstract: A system includes a computing platform having a hardware processor and a memory storing a software code and a neural network (NN) having multiple layers including a last activation layer and a loss layer. The hardware processor executes the software code to identify different combinations of layers for testing the NN, each combination including candidate function(s) for the last activation layer and candidate function(s) for the loss layer. For each different combination, the software code configures the NN based on the combination, inputs, into the configured NN, a training dataset including multiple data objects, receives, from the configured NN, a classification of the data objects, and generates a performance assessment for the combination based on the classification. The software code determines a preferred combination of layers for the NN including selected candidate functions for the last activation layer and the loss layer, based on a comparison of the performance assessments.

Abstract: The invention relates to a method for isolating a biomolecule. A liquid sample comprising the biomolecule is contacted with an electrically conductive surface. The surface carries a chemical modification facilitating retention of said biomolecule, or an electrical retention potential is applied to said surface. The biomolecule is released by applying a voltage to the surface. The invention further relates to a device comprising a chamber configured for receiving a liquid sample, wherein a first surface of said chamber is a working electrode formed by a high-surface, electrochemically active material embedded in a non-electrically conductive polymer matrix. The device further comprises a counter electrode and connections to a voltage source. The invention further relates to a device and method for loading an extracellular vesicle with cargo molecules.

Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

Abstract: The present invention relates to a mutant receptor-binding domain (mRBD) of a coronavirus (mRBD-CORONA) or a fragment thereof and mutant spike protein of the coronavirus (CORONA-mSpike) or a fragment thereof comprising the CORO-NA-mRBD or the fragment thereof. Furthermore, the present invention relates to a polypeptide or protein comprising the mRBD-CORONA or the fragment thereof or CORONA-mSpike or the fragment thereof and a nucleic acid comprising a nucleotide sequence encoding for the mRBD-CORONA or the fragment thereof or the CORONA-mSpike or the fragment thereof. Furthermore, the present invention relates to a vaccine composition comprising one or more CORONA-mRBDs or fragments thereof, one or more CORONA-mSpikes, one or more polypeptides or proteins and/or one or more nucleic acids according to the present invention.

Abstract: A patch for detecting by at least one non-invasive imaging technique a leak of a biological fluid at an application site, wherein the patch includes either a layer including one or more first portions containing a first gel, one or more second portions containing a second gel and at least one sensing component embedded within the first gel and/or the second gel, or a layer containing a hydrogel and at least one sensing component, such as aerogel particles, and xerogel particles, embedded within the hydrogel.