Patents Assigned to Ethicon
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Publication number: 20240148933Abstract: The present invention is directed to compressed hemostatic tablets or forms comprising a fibrous non-woven oxidized cellulose (OC or ORC) multilayer material compressed into a form stable tablet, further comprising calcium salt, with the tablets rapidly expandable on contact with blood or blood plasma. The compressed forms may further comprise a multi-arm PEG-SG and are dimensionally, preferably with regard to length and width, stable for at least 48 hours after compression. In some embodiments, the compressed forms will expand upon contact with blood from 1.5 to 5 times of tablet length in 5 seconds; from 2 to 6 times of tablet length in 20 seconds; and from 3 to 6 times of tablet length in 5 minutes. The compressed forms are effective in hemostasis in heparinized blood.Type: ApplicationFiled: November 8, 2022Publication date: May 9, 2024Applicant: Ethicon, Inc.Inventors: Yi-Lan Wang, Tien-Jung Lee
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Patent number: 11974734Abstract: A device for application onto incisions or wounds with a liquid rapidly polymerizable adhesive for forming skin closure systems, comprising a flat porous mesh elongated along a longitudinal axis and having an upper side and an opposing lower or wound facing side and a central portion in immediate vicinity of the axis; further having a plurality of pores and windows in said mesh, said windows substantially larger than said pores and arranged along said longitudinal axis in said central portion; a crosslinking or polymerization accelerator or initiator disposed in or on said mesh; and a pressure sensitive adhesive disposed on at least a portion of the lower surface of said mesh.Type: GrantFiled: March 31, 2021Date of Patent: May 7, 2024Assignee: Ethicon, Inc.Inventors: Julian QUintero, Leo B. Kriksunov, Elena Wolfe
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Patent number: 11974744Abstract: Methods for applying one or more adjuncts to tissue are provided. In one embodiment, the method can include positioning an adjunct, e.g., using an adhesive, on one of first and second jaws of an end effector of a surgical stapler. In one embodiment, an attachment mechanism on the adjunct can prevent stretching of at least a portion of the adjunct. In other aspects, the adjunct can be maintained on the at least one jaw in a first state in which the adjunct is at least partially stretched over the at least one jaw, and actuation of the surgical stapler can cause the adjunct to transition from the first state to a second state such that the adjunct in the second state at least partially separates from the at least one jaw.Type: GrantFiled: February 24, 2021Date of Patent: May 7, 2024Assignee: ETHICON LLCInventors: Frederick E. Shelton, IV, Jason L. Harris, Michael J. Vendely, Prudence Vulhop
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Patent number: 11969524Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.Type: GrantFiled: January 5, 2023Date of Patent: April 30, 2024Assignee: Ethicon, Inc.Inventors: Duan Li Ou, Christophe Vailhe, Frank R. Cichocki, Jr.
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Patent number: 11957324Abstract: Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.Type: GrantFiled: May 12, 2021Date of Patent: April 16, 2024Assignees: Ethicon, Inc., Omrix Biopharmaceuticals, Ltd.Inventors: Ashley DeAnglis, Yair Pilpel, Yuri Zherdev, Sivan Doron, Lior Erez
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Patent number: 11957326Abstract: The present invention is directed to a variable length applicator system for delivery of at least one medically useful liquid, comprising an elongated, telescopically extendable, variable length cannula having a liquid pump containing said liquid connected to said cannula at a proximal end, and a spray nozzle mounted on said cannula at a distal end; a coiled and extendable tubular conduit connected to and in fluid communication with, both said liquid pump and said spray nozzle; wherein an axial extension of said cannula is configured to cause a matching axial extension of said coiled tubular conduit.Type: GrantFiled: April 19, 2022Date of Patent: April 16, 2024Assignee: Ethicon, Inc.Inventors: Jianxin Guo, Sridevi N. Dhanaraj, Leo Kriksunov
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Patent number: 11950994Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, and an elongated shaft extending from the housing. The elongated shaft has a proximal end secured to the housing, a distal end spaced from the proximal end, and a first axis extending between the proximal and distal ends of the elongated shaft. Surgical fasteners are disposed in the elongated shaft. The surgical fasteners are stacked at an angle relative to the first axis of the elongated shaft. A distal end cap having a surgical fastener dispensing window is secured to the distal end of the elongated shaft. The applicator instrument has a firing system disposed in the housing, and an actuator coupled with the firing system for activating the firing system to dispense the surgical fasteners through the surgical fastener dispensing window.Type: GrantFiled: September 8, 2022Date of Patent: April 9, 2024Assignee: Ethicon, Inc.Inventors: Michael Cardinale, Doug Souls, Anthony Miksza, Aaron J. Brickner, Jared Schneider, Todd Sack, David R. Schiff, Erin Elizabeth Wenig
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Patent number: 11938165Abstract: Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.Type: GrantFiled: August 18, 2021Date of Patent: March 26, 2024Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.Inventors: Tamar Auerbach-Nevo, Ashley Deanglis, Israel Nur
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Publication number: 20240066178Abstract: The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.Type: ApplicationFiled: August 30, 2022Publication date: February 29, 2024Applicant: Ethicon, Inc.Inventors: Salim A. Ghodbane, Sai Veruva, Mark Neubauer
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Publication number: 20240066052Abstract: The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.Type: ApplicationFiled: August 30, 2022Publication date: February 29, 2024Applicant: Ethicon, Inc.Inventors: Salim A. Ghodbane, Sridevi Dhanaraj, Brian Aitken
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Patent number: 11883554Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.Type: GrantFiled: April 13, 2021Date of Patent: January 30, 2024Assignee: Ethicon, Inc.Inventors: Yi-Lan Wang, Leo B. Kriksunov
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Patent number: 11885735Abstract: The present is directed to systems for ex vivo testing performance of a hemostatic or sealing product attached to an animal organ and fully covering a cored channel in said organ, comprising: a pressure sensor positioned proximate to said hemostatic or sealing product in said cored channel; a monitoring or recording device configured to receive pressure readings from said pressure sensor; and a pressurized fluid source connected to said cored channel and configured to supply said pressurized fluid into said cored channel under constant or variable pressure. The present invention is also directed to methods of use for such systems.Type: GrantFiled: September 13, 2019Date of Patent: January 30, 2024Assignee: Ethicon, Inc.Inventors: John Matonick, Kevin Hengst, Matthew Pfefferkorn, Robert J. Tannhauser, Leo B. Kriksunov
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Patent number: 11883264Abstract: A system or device for skin closure comprises an elastic flat flexible tape elongated along a longitudinal axis and having a lower side and an opposing upper side, said tape having a pressure sensitive adhesive on at least a portion of the lower side, said tape having a plurality of openings arranged side-by-side with spaces between said openings oriented across the longitudinal axis.Type: GrantFiled: October 10, 2019Date of Patent: January 30, 2024Assignee: Ethicon, Inc.Inventors: Julian Quintero, Kevin S. Weadock, Leo B. Kriksunov, Robert J. Tannhauser
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Patent number: 11872584Abstract: A spray device includes side-by-side spray tips that are spaced from one another at a distal end of the spray device. A first spray tip has a first fluid pathway defining a first flow area. The first fluid pathway has a first swirl chamber having an outer perimeter and flutes having inner ends that direct a first fluid into the outer perimeter of the first swirl chamber for rotating the first fluid in a circular pattern. A second spray tip has a second fluid pathway that defines a second flow area that is larger than the first flow area. The second fluid pathway has a second swirl chamber having an outer perimeter and flutes having inner ends that direct a second fluid into the outer perimeter of the second swirl chamber for rotating the second fluid in a circular pattern.Type: GrantFiled: February 9, 2022Date of Patent: January 16, 2024Assignee: Ethicon, Inc.Inventors: Michael J. Trezza, II, Salim A. Ghodbane, Simon Cohn
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Patent number: 11839701Abstract: A novel two-step process for batch coating surgical needles with cross-linked silicone coatings is disclosed. The surgical needles are cured using a two-step process. The coatings on the needles are partially cured in the first step and mechanically separated. The coatings on the needles are then fully cured in the second step.Type: GrantFiled: November 24, 2020Date of Patent: December 12, 2023Assignee: Ethicon, Inc.Inventor: Duan Li Ou
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Patent number: 11832812Abstract: A system for making a surgical suture having a reformed tip includes a receiver die having a top surface, a bottom surface, and an elongated channel formed in the top surface that extends between first and second ends of said receiver die. The elongated channel includes a suture channel having a first end and a second end, a first sloping surface that extends downwardly between the first end of the suture channel and the first end of the receiver die, and a second sloping surface that extends downwardly between the second end of the suture channel and the second end of the receiver die. The system includes an upper die having a top surface and a bottom surface that opposes the top surface of the receiver die. The system has an open die position in which the bottom surface of the upper die is spaced away from the top surface of the receiver die and a closed die position in which the bottom surface of the upper die is in contact with the top surface of the receiver die.Type: GrantFiled: December 15, 2021Date of Patent: December 5, 2023Assignee: Ethicon, Inc.Inventor: Robert A. Rousseau
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Patent number: 11832825Abstract: An implantable device for control over the size of emphysematous bullae in a lung, including: an elongated central region having a fixed axial length; a first end including a first anchor; and a second end including a second anchor.Type: GrantFiled: November 4, 2019Date of Patent: December 5, 2023Assignee: Ethicon, Inc.Inventors: Rudolph Cedro, Jr., Kevin S. Weadock, Leo B. Kriksunov
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Patent number: 11833496Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.Type: GrantFiled: December 16, 2021Date of Patent: December 5, 2023Assignee: Ethicon, Inc.Inventor: Duan Li Ou
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Patent number: 11826028Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.Type: GrantFiled: June 10, 2020Date of Patent: November 28, 2023Assignee: Ethicon, Inc.Inventors: Nir Nativ, Sridevi Dhanaraj, Ashley DeAnglis, Salim Ghodbane
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Patent number: D1020334Type: GrantFiled: October 2, 2020Date of Patent: April 2, 2024Assignee: Ethicon, Inc.Inventors: Matthew Chila, Kevin McHale, Alex Weber