Patents Assigned to Ethicon Endo-Surgery, Inc.
  • Patent number: 10687808
    Abstract: Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a method of gastric volume reduction is disclosed that includes advancing a tissue acquisition and fixation device endoscopically into a stomach, manipulating the device to form a first fold of tissue on an interior surface of an anterior wall of the stomach, and manipulating the device to form a second fold of tissue on an interior surface of a posterior wall of the stomach, where the second fold is not attached to the first fold.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: June 23, 2020
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Kevin D. Felder, Lawrence Crainich, Justin W. Sherrill, Jason L. Harris, Mark S. Zeiner
  • Patent number: 10668104
    Abstract: Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: June 2, 2020
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, Taylor W. Aronhalt, James W. Voegele
  • Publication number: 20200168415
    Abstract: A method of adjusting a switch of a device, which comprises using a biasing force-adjusting element, adjusting a magnitude of a biasing force imparted to a switching element of the switch by a biasing element disposed about the switching element, wherein the switching element is movably disposed within an interior cavity of a hollow body of the switch and the biasing force places the switching element in one of a first position and a second position. The first position corresponds to a first electrical state and the second position corresponds to a second electrical state.
    Type: Application
    Filed: December 27, 2019
    Publication date: May 28, 2020
    Applicant: Ethicon Endo-Surgery, Inc.
    Inventor: Kevin W. Smith
  • Patent number: 10610226
    Abstract: Adjunct material and methods of using adjunct material to reinforce a staple line are provided herein. In general, adjunct material can be used to maintain a seal in tissue and prevent stapled tissue from tearing. This adjunct material can be coupled to a jaw of a surgical stapler, and can be deployed into tissue along with the staples. In some embodiments, the adjunct material can be sized and shaped so that a portion of the material extends laterally outside of the staple line and distributes strain to tissue outside of the staple line. In certain aspects, sealant can be applied to the staple line and to the adjunct material in various ways to further seal the tissue and/or prevent leaks from forming in the tissue.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: April 7, 2020
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Frederick E. Shelton, IV, Jason L. Harris, Jeffrey S. Swayze, Mark S. Zeiner, Thomas Lee Craven, Anne J. Gorman, Bret W. Smith
  • Patent number: 10586669
    Abstract: A method of creating a switch, comprising disposing a switching element movably within an interior cavity of the switch to define switch-making and switch-breaking positions along a switching axis of the switching element, disposing a biasing element about the switching element to impart a biasing force to the switching element to place the switching element in one of the switch-making and switch-breaking positions until an external force imparted to the switching element exceeds the biasing force to cause the switching element to change to the other position, disposing a biasing force-adjusting element in cooperative engagement with the biasing element such that a magnitude of the biasing force is adjustable, and coupling a conductive contact to the switching element to define a switch-making state when the switching element is in the switch-making position and a switch-breaking state when the switching element is in the switch-breaking position.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: March 10, 2020
    Assignee: Ethicon-Endo Surgery, Inc.
    Inventor: Kevin W. Smith
  • Patent number: 10441459
    Abstract: Methods and devices are provided for activating brown adipose tissue (BAT) with cooling. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by cooling tissue having a high density of cold sensitive thermoreceptors and/or by cooling BAT depots directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: October 15, 2019
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Taylor W. Aronhalt, Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, James W. Voegele, Mark S. Ortiz
  • Patent number: 10441808
    Abstract: Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: October 15, 2019
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Jason L. Harris, Lee M. Kaplan, David N. Plescia, Taylor W. Aronhalt, James W. Voegele, Nicholas Stylopoulos
  • Patent number: 10413292
    Abstract: The present invention provides a linear stapler having a multi-functional retaining pin subassembly. The linear stapler comprises a handle stem connecting an anvil to a handle, and the retaining pin subassembly is movably supported on the handle stem and comprises a connecting cover having a retaining pin extending from the connecting cover. The present invention also provides a multi-functional retaining pin subassembly. The retaining pin subassembly can achieve cartridge alignment and tissue retention during the firing of the stapler and protect tissue from unintended damage.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: September 17, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Shan Wan, Xiangchun Hong, Lian Xu, Wei Sun
  • Patent number: 10383754
    Abstract: Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: August 20, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Thomas E. Albrecht, Michael S. Cropper, Jason L. Harris, Christopher J. Hess, John V. Hunt, Mark D. Overmyer, Frederick E. Shelton, IV, Michael J. Stokes, William B. Weisenburgh, II, Tamara S. Vetro Widenhouse, Andrew M. Zwolinski
  • Patent number: 10350099
    Abstract: An endoluminal sleeve device for internally lining a section of the GI tract, comprises a sleeve configured for deployment inside a duodenum, the sleeve having walls of a flexible material defining a sleeve lumen, a proximal end defining a proximal lumen opening, and a distal end defining a distal lumen opening, an anchoring component having a slender transport configuration and a bulky deployed configuration, wherein the anchoring component is locatable at a distance from the proximal sleeve end and connected thereto by an elongated tether.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: July 16, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Thomas E. Albrecht, Mark S. Zeiner, Jason L Harris, Michael J. Stokes, Mark S. Ortiz, Kevin D. Felder, Michele D'Arcangelo, James W. Voegele
  • Patent number: 10350050
    Abstract: A method for treating a patient includes creating at least one incision to gain access to an peritoneal cavity, performing a gastric volume reduction procedure and introducing a device to prevent gastric contents from interacting with at least a portion of the duodenum.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: July 16, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Jason L. Harris, Mark S. Zeiner, Michael J. Stokes
  • Patent number: 10342544
    Abstract: An apparatus is operable to provide an anastomosis coupling two hollow organs, such as a duodenum and ileum. The apparatus includes a first component that is inserted through an enterotomy in a first hollow organ and a second component that is inserted through an enterotomy in a second hollow organ. The first and second components are brought together to o align the enterotomies and compress apposed layers of tissue adjacent to the enterotomies. The compressed tissue eventually necroses and the apparatus may be removed or simply pass through the hollow organ. Each component may include a set of pivoting links and a resilient member that is configured to both bias the links to an expanded configuration and grip the tissue adjacent to the enterotomy. The components may include magnets that secure the positioning of the components relative to each other and provide a compressive force on the apposed tissue.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: July 9, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Gregory J. Bakos, Mark S. Zeiner
  • Patent number: 10314649
    Abstract: A surgical instrument, such as an electrical ablation device, includes an elongate member having therealong disposed a first electrode extending along an axis. A first expandable portion extends along the axis and defines a first perimeter of the first electrode and has an associated first diameter with respect to the axis. The first expandable portion includes a first framework selectively expandable to transition the first expandable portion from a contracted state to an expanded state. The first framework is selectively contractible to transition the first expandable portion from the expanded state to the contracted state. When the first framework is expanded, the first diameter is expanded and the first expandable portion is transitioned from the contracted state to the expanded state. When the first framework is contracted, the first diameter is contracted and the first expandable portion is transitioned from the expanded state to the contracted state.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: June 11, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Gregory J. Bakos, David N. Plescia, Gary L. Long, Peter K. Shires
  • Patent number: 10307280
    Abstract: A duodenal sleeve assembly comprises a sleeve, an expandable sealing member, a tether, and an expandable anchor. The sleeve is secured to the sealing member. The tether couples the anchor with the sealing member. A deployment instrument comprises a shaft assembly, a first retention member, and a second retention member. The first retention member selectively secures the sealing member to the shaft assembly. The second retention member selectively secures the anchor to the shaft assembly. When the first retention member is released, the sealing member expands outwardly to seal the proximal end of the sleeve against the mucosa of the patient's duodenum. When the second retention member is released, the anchor expands outwardly within the stomach to anchor the sleeve assembly relative to the stomach. The tether traverses the pylorus. The sleeve isolates chyme from enzymes in the duodenum; and the mucosa of the duodenum from nutrients in the chyme.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: June 4, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Mark S. Zeiner, Mark S. Ortiz, David B. Griffith
  • Patent number: 10292703
    Abstract: Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a method of gastric volume reduction is disclosed that includes advancing a tissue acquisition and fixation device endoscopically into a stomach, manipulating the device to form a first fold of tissue on an interior surface of an anterior wall of the stomach, and manipulating the device to form a second fold of tissue on an interior surface of a posterior wall of the stomach, where the second fold is not attached to the first fold.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: May 21, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Kevin D. Felder, Lawrence Crainich, Justin W. Sherrill, Jason L. Harris, Mark S. Zeiner
  • Publication number: 20190139729
    Abstract: A method of creating a switch, comprising disposing a switching element movably within an interior cavity of the switch to define switch-making and switch-breaking positions along a switching axis of the switching element, disposing a biasing element about the switching element to impart a biasing force to the switching element to place the switching element in one of the switch-making and switch-breaking positions until an external force imparted to the switching element exceeds the biasing force to cause the switching element to change to the other position, disposing a biasing force-adjusting element in cooperative engagement with the biasing element such that a magnitude of the biasing force is adjustable, and coupling a conductive contact to the switching element to define a switch-making state when the switching element is in the switch-making position and a switch-breaking state when the switching element is in the switch-breaking position.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 9, 2019
    Applicant: Ethicon Endo-Surgery, Inc.
    Inventor: Kevin W. Smith
  • Patent number: 10258795
    Abstract: A system for stimulating the release of satiety hormone in a subject comprises a stimulus device which is implantable in the subject and adapted to apply an electrical stimulus to a tissue of a gastrointestinal system of said subject, and a detection device which is implantable in the subject and adapted to continuously monitoring at least one of a mechanical characteristic and an electrical characteristic of the subject to detect an ingestion of food by said subject, wherein the detection device cooperates with the stimulus device such that the stimulus device applies said electrical stimulus in response to a detected ingestion of food.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: April 16, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Toralf Bork, Rocco Crivelli, Mathilde Miguras, Martin Pfleiderer, Yanik Tardy, Jason L. Harris, Mark S. Ortiz
  • Patent number: 10242756
    Abstract: Various systems and methods for predicting metabolic and bariatric surgery outcomes are provided. The systems and methods can also provide predictions for non-surgical metabolic and bariatric treatments. In general, a user can receive predictive outcomes of multiple bariatric procedures that could be performed on a patient. In one embodiment, a user can electronically access a metabolic and bariatric surgery outcome prediction system, e.g., using one or more web pages. The system can provide predictive outcomes of one or more different bariatric surgeries for the patient based on data gathered from the user and on historical data regarding outcomes of the different bariatric surgeries. The system can additionally provide predictive outcomes for not having any treatment and/or a comparison of the predictive outcomes of the one or more different bariatric surgeries to the predictive outcomes for not having any treatment.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: March 26, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Jason L. Harris, Christopher J. Hess, Nitin Kumar Jain, Diane M. Francis, Thomas E. Albrecht, Tina Denise Hunter
  • Patent number: 10217582
    Abstract: A method of creating a switch, comprising disposing a switching element movably within an interior cavity of the switch to define first and second positions along a switching axis of the switching element, disposing a biasing element about the switching element to impart a biasing force to the switching element to place the switching element in one of the first and second positions until an external force imparted to the switching element exceeds the biasing force to cause the switching element to move to the other position, disposing a biasing force-adjusting element in cooperative engagement with the biasing element such that a magnitude of the biasing force is adjustable, and coupling a conductive contact to the switching element to define a first switching state when the switching element is in the first position and a second switching state when the switching element is in the second position.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: February 26, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventor: Kevin W. Smith
  • Patent number: 10201695
    Abstract: Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: February 12, 2019
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Jason L. Harris, Nicholas Stylopoulos, Lee M. Kaplan, Tamara C. Baynham, Taylor W. Aronhalt