Abstract: A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.

Abstract: The present invention relates to a hemostatic absorbable composition, comprising: a flowable plurality of separate aggregates each comprising: a plurality of absorbable carrier particles coated on a surface thereof by a plurality of smaller particles comprising an absorbable supplemental hemostasis-promoting agent. In some embodiments, the absorbable carrier particles comprise gelatin or collagen, and the supplemental hemostasis-promoting agent comprises oxidized cellulose, oxidized regenerated cellulose, carboxylic oxidized cellulose, carboxylic oxidized regenerated cellulose, thrombin, or tranexamic acid.

Abstract: The present invention is directed to continuous reaction processes for preparing a glycolide/L-lactide copolymer formulation by continuously introducing glycolide monomer, L-lactide monomer, initiator and optionally a catalyst into at least one continuous reactor vessel under dry nitrogen environment, wherein the monomers, initiator, and optional catalyst are mixed at a first lower temperature and then transferred to a second continuous reactor operating at a second higher temperature, and then exothermally reacting and maintaining at a steady state, the blend of glycolide monomer, lactide monomer, initiator and optional catalyst to produce a PLGA copolymer reaction product.

Abstract: An image of a zone of inhibition (ZOI) plate is received. The image is processed to detect sutures within the image of the ZOI plate using computer vision, detect a contour of a ZOI within the image of the ZOI plate using computer vision, generate an overlay based on smoothening the contour of the ZOI and perform one or measurements on the image of the ZOI plate, wherein each of the one or more measurements comprises a distance between the sutures and the overlay.

Abstract: A reinforcing incision drape for tissue, such as fragile tissue, includes an absorbable surgical mesh having top and bottom major surfaces. The absorbable surgical mesh has a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The stitching zone is less porous and the first and second reinforcing zones are more porous than the stitching zone. A releasable liner covers the top major surface of the absorbable surgical mesh within the stitching zone of the absorbable surgical mesh. A weaker adhesive, such as a pressure sensitive adhesive, covers the bottom major surface of the surgical mesh within the centrally located stitching zone of the absorbable surgical mesh, and a stronger adhesive, such as cyanoacrylite, covers the first and second reinforcing zones of the absorbable surgical mesh.

Abstract: A bioscaffold structure is provided, the bioscaffold comprising a plurality of connected unit cells, each unit cell comprising a plurality of filaments composed of an extracellular material containing Collagen I and Collagen III, wherein each of the plurality of unit cells includes at least one opening connected to an internal volume.

Abstract: A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.

Abstract: A spray tip for dispensing fluids that react together includes a first lumen for a first fluid, a second lumen for a second fluid, and a dispensing cap located at distal ends of the respective first and second lumens and defining a distal end of the spray tip. The dispensing cap includes a distal end wall defining a closed end of the dispensing cap, a first spray opening formed in the distal end wall that is in fluid communication with the first lumen, a second spray opening formed in the distal end wall that is in fluid communication with the second lumen, and an external dividing wall that projects distally from the distal end wall of the dispensing cap and that extends between the first and second spray opening for forming a barrier between the first and second spray openings.

Abstract: A co-reactive liquids delivery applicator, including first and second hollow cylindrical cartridges, each including a stopper at a proximal end and a sealing septum on a distal end and the cartridges containing co-reactive liquids therein, an applicator body including two adjacent chambers configured to secure the first and second cylindrical cartridges, a manifold positioned at a distal portion of the applicator body, the manifold including a pair of hollow needles extending from a proximal portion and a tip connection positioned at a distal portion thereof, and a toggle configured to advance the manifold towards the distal end of the cartridge, wherein upon advancing the manifold each hollow needle penetrates the sealing septum and establishes fluid communication with one of the liquids of the first and second cylindrical cartridges.

Abstract: A method for navigating a probe to a location within a body of a patient, the method comprising visualizing a three-dimensional image of a region of a body of a patient; receiving a selection of a target location within said three-dimensional image of a region of a patient's body; determining and visualizing a preferred pathway for the probe to follow from an external entry point on the patient's body to the target location; visualizing the preferred pathway for the probe simultaneously with an indication of the current actual position of the probe in real time such that the simultaneous visualizations enables a user to align the current actual position of the probe with the preferred pathway; and updating and visualizing an indication of the current actual position of the probe in real time as the probe is advanced to the target location.

Abstract: A spinneret for extruding fibers includes a plate having a proximal surface and a distal surface. The spinneret includes a plurality of holes formed in the plate that extend between the proximal surface and the distal surface of the plate. The holes are spaced from one another, and each hole has a distal end that extends along a central axis. The spinneret has a plurality of contoured entrance zones formed in the proximal surface of the plate, whereby each contoured entrance zone is associated with one of the holes. Each contoured entrance zone extends distally from the proximal surface of the plate to a proximal end of the hole associated therewith. Each contoured entrance zone has substantially no planar or flat surfaces normal to the direction of the central axis of the distal end of the hole associated therewith.

Abstract: Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.

Abstract: The present invention is directed to a length adaptive surgical suture comprising a monofilament or a braid of a plurality of filaments, the suture having an original length when implanted and a second length that is different from the original length within a first twenty-four (24) hour period of time after implantation to accommodate tissue swelling. The present invention is also directed to configurations and combinations that enable length adaptive results.

Abstract: A dispensing device to deliver a multiple component material to a location in vivo. The device includes a manifold having proximal and distal ends and multiple separate lumens within it, connectable on its proximal end to multiple syringes for containing the multiple component material, a distal tip assembly comprising a tip connector having separate side-by-side lumens within the tip connector and optionally a dispensing tip, and multiple flexible side-by-side cannulae. Each cannulae has a proximal end and a distal end, the proximal ends of the cannulae are connected to a separate lumen at the distal end of the manifold, and the distal ends of the cannulae are connected to one of the side-by-side lumens of the tip connector, establishing a fluid communication between the manifold and the distal tip assembly, wherein the side-by-side cannulae are optionally partially connected along their length and are split at their proximal and distal ends.

Abstract: Systems, computer-readable instructions, and methods for storing products are disclosed. For example, the system may include modular shelving units that include a shelf which is placeable on a rack, the shelf including a platform, the shelf having a weight sensor below the platform, the platform is configured to support N number of holders, each of the N holders configured to store products, each shelf further having N?1 optical sensors below the N?1 holders when the N?1 holders are supported by the platform and N?1 windows above the N?1 optical sensors, the N?1 optical sensors being in proximity of the N?1 holders, respectively, wherein each holder includes an opening, wherein when a holder is on the shelf, the opening is capable of being aligned with an optical sensor, the shelf further having a processing circuit coupled to the N?1 optical sensors and the weight sensor.

Abstract: A mixing and spraying assembly for a tissue sealant includes a mixing assembly, a spray tip assembly, and a malleable section having a proximal end connected with the mixing assembly and a distal end connected with the spray tip assembly for enabling the spray tip assembly to be angulated relative to the mixing assembly. The malleable section includes a flexible shaft having a length, a malleable wire conduit that extends along the length of the flexible shaft, and a malleable wire disposed in the malleable wire conduit. The malleable wire is longer than the flexible shaft and has a proximal end that is connected to the mixing assembly and a distal end that is connected to the spray tip assembly. First and second fluids are mixed within the mixing assembly to form a tissue sealant that is delivered through the malleable section for being expressed from the spray tip assembly.

Abstract: The present invention is directed to an absorbable hemostatic patch that utilizes a biocompatible fibrous, fabric substrate that is melt-blown and napped or loosened at the surface, with the substrate having a low-profile, high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ultimately effective for use as a hemostat in situations of problematic bleeding.

Abstract: A reconfigurable suture needle includes an elongated body having a curved proximal section and a curved distal section. The curved proximal section is hollow and includes an elongated conduit extending from a proximal end to a distal end thereof. The curved distal section includes a needle point at a distal end thereof and a hollow post projecting proximally from a proximal end thereof. A suture thread passes through the elongated conduit of the curved proximal section and has a distal end that passes through the hollow post of the curved distal section for being secured to the proximal end of the curved distal section.

Abstract: Disclosed is a sealant, and techniques for making and using the sealant. The sealant may include three components that, when combined, produce the sealant: an electrophilic component, a nucleophilic component, and a doping component. The electrophilic component may include a first electrophilic material having a first functionality of a first reactive group. The nucleophilic component may include a first nucleophilic material having a second functionality of a second reactive group. The doping component may include a second electrophilic material having a third functionality of the first reactive group greater than the first functionality and/or a second nucleophilic material having a fourth functionality of the second reactive group greater than the second functionality. The doping component may be present in an amount sufficient to provide a 2-20% molar contribution of the first reactive group and/or the second reactive group in the sealant.