Patents Assigned to Ethicon, Inc.
  • Publication number: 20240066178
    Abstract: The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.
    Type: Application
    Filed: August 30, 2022
    Publication date: February 29, 2024
    Applicant: Ethicon, Inc.
    Inventors: Salim A. Ghodbane, Sai Veruva, Mark Neubauer
  • Publication number: 20240066052
    Abstract: The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.
    Type: Application
    Filed: August 30, 2022
    Publication date: February 29, 2024
    Applicant: Ethicon, Inc.
    Inventors: Salim A. Ghodbane, Sridevi Dhanaraj, Brian Aitken
  • Patent number: 11885735
    Abstract: The present is directed to systems for ex vivo testing performance of a hemostatic or sealing product attached to an animal organ and fully covering a cored channel in said organ, comprising: a pressure sensor positioned proximate to said hemostatic or sealing product in said cored channel; a monitoring or recording device configured to receive pressure readings from said pressure sensor; and a pressurized fluid source connected to said cored channel and configured to supply said pressurized fluid into said cored channel under constant or variable pressure. The present invention is also directed to methods of use for such systems.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: January 30, 2024
    Assignee: Ethicon, Inc.
    Inventors: John Matonick, Kevin Hengst, Matthew Pfefferkorn, Robert J. Tannhauser, Leo B. Kriksunov
  • Patent number: 11883554
    Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 30, 2024
    Assignee: Ethicon, Inc.
    Inventors: Yi-Lan Wang, Leo B. Kriksunov
  • Patent number: 11883264
    Abstract: A system or device for skin closure comprises an elastic flat flexible tape elongated along a longitudinal axis and having a lower side and an opposing upper side, said tape having a pressure sensitive adhesive on at least a portion of the lower side, said tape having a plurality of openings arranged side-by-side with spaces between said openings oriented across the longitudinal axis.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: January 30, 2024
    Assignee: Ethicon, Inc.
    Inventors: Julian Quintero, Kevin S. Weadock, Leo B. Kriksunov, Robert J. Tannhauser
  • Patent number: 11872584
    Abstract: A spray device includes side-by-side spray tips that are spaced from one another at a distal end of the spray device. A first spray tip has a first fluid pathway defining a first flow area. The first fluid pathway has a first swirl chamber having an outer perimeter and flutes having inner ends that direct a first fluid into the outer perimeter of the first swirl chamber for rotating the first fluid in a circular pattern. A second spray tip has a second fluid pathway that defines a second flow area that is larger than the first flow area. The second fluid pathway has a second swirl chamber having an outer perimeter and flutes having inner ends that direct a second fluid into the outer perimeter of the second swirl chamber for rotating the second fluid in a circular pattern.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: January 16, 2024
    Assignee: Ethicon, Inc.
    Inventors: Michael J. Trezza, II, Salim A. Ghodbane, Simon Cohn
  • Patent number: 11839701
    Abstract: A novel two-step process for batch coating surgical needles with cross-linked silicone coatings is disclosed. The surgical needles are cured using a two-step process. The coatings on the needles are partially cured in the first step and mechanically separated. The coatings on the needles are then fully cured in the second step.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: December 12, 2023
    Assignee: Ethicon, Inc.
    Inventor: Duan Li Ou
  • Patent number: 11832812
    Abstract: A system for making a surgical suture having a reformed tip includes a receiver die having a top surface, a bottom surface, and an elongated channel formed in the top surface that extends between first and second ends of said receiver die. The elongated channel includes a suture channel having a first end and a second end, a first sloping surface that extends downwardly between the first end of the suture channel and the first end of the receiver die, and a second sloping surface that extends downwardly between the second end of the suture channel and the second end of the receiver die. The system includes an upper die having a top surface and a bottom surface that opposes the top surface of the receiver die. The system has an open die position in which the bottom surface of the upper die is spaced away from the top surface of the receiver die and a closed die position in which the bottom surface of the upper die is in contact with the top surface of the receiver die.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: December 5, 2023
    Assignee: Ethicon, Inc.
    Inventor: Robert A. Rousseau
  • Patent number: 11833496
    Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: December 5, 2023
    Assignee: Ethicon, Inc.
    Inventor: Duan Li Ou
  • Patent number: 11832825
    Abstract: An implantable device for control over the size of emphysematous bullae in a lung, including: an elongated central region having a fixed axial length; a first end including a first anchor; and a second end including a second anchor.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: December 5, 2023
    Assignee: Ethicon, Inc.
    Inventors: Rudolph Cedro, Jr., Kevin S. Weadock, Leo B. Kriksunov
  • Patent number: 11826796
    Abstract: A blackened surgical needle made by the method of treating blackened surgical needles, comprising the steps of: a. determining that a blackening process may have produced loose black oxide particles on the blackened surgical needle; b. placing at least one blackened surgical needle having loose black oxide particles on its surface into a bath, wherein the bath comprises: i. an effective amount of citric acid to remove loose black oxide particles from the at least one blackened surgical needle; and ii. a source of ultrasound; and c. applying the ultrasound in the bath for a time sufficient to remove loose black oxide particles from the surface of the at least one needle and wherein the contents of the bath are maintained at a pH below 3.25.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: November 28, 2023
    Assignee: Ethicon, Inc.
    Inventors: Duan Li Ou, Christophe Vailhe
  • Patent number: 11826028
    Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: November 28, 2023
    Assignee: Ethicon, Inc.
    Inventors: Nir Nativ, Sridevi Dhanaraj, Ashley DeAnglis, Salim Ghodbane
  • Patent number: 11819384
    Abstract: The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: November 21, 2023
    Assignees: Guangzhou Bioseal Co., Ltd., Johnson & Johnson China Ltd., Ethicon, Inc.
    Inventors: Dengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
  • Publication number: 20230348722
    Abstract: Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.
    Type: Application
    Filed: July 5, 2023
    Publication date: November 2, 2023
    Applicant: Ethicon, Inc.
    Inventor: Duan Li Ou
  • Publication number: 20230348191
    Abstract: Systems, computer-readable instructions, and methods for dispensing and tracking medical products in various medical locations are disclosed. For example, the system may include a server which receives one or more requests for types of medical products from one or more client devices, determines whether the requested types and quantities are available in a dispenser and issues an instruction to the dispenser to automatically dispense the requested medical products and quantities. The server may receive confirmation after the types of medical products are dispensed from the dispenser and update a database. The server may receive unused and used medical product information from a client device and reconcile with restocked medical product information from the dispenser. Available types of medical products and quantities, usage reports and recommendations may be viewed via a Platform by one or more client devices. The dispenser may receive requests directly from a client device for medical products.
    Type: Application
    Filed: July 5, 2023
    Publication date: November 2, 2023
    Applicant: Ethicon, Inc.
    Inventors: Matthew Chila, Jonathan Addeo Syby, Allen Keith On, David Mickle Wade, Matteo Josue Piedra, Lewis Arthur Lau
  • Patent number: 11801324
    Abstract: The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: October 31, 2023
    Assignees: Ferrosan Medical Devices A/S, Ethicon Inc.
    Inventors: Peter Lund Hammershøj, Kristian Larsen, Douglas B. Johns, Nicole Smith, Michael Cardinale, Gabriella Ferrara, Guanghui Zhang
  • Patent number: 11793948
    Abstract: The present invention is directed to a spray applicator for spraying a tissue treatment medicant onto a tissue that has a container containing the medicant and is positioned at a proximal end of the spray applicator; a spray tip positioned at a distal end of the spray applicator; a cannula connecting the container with the spray tip; an actuatable dispensing mechanism at a proximal end of the applicator to express the medicant from the container through the cannula and through the spray tip toward the tissue; an optional pressurized gas source discharging a gas through the cannula in the vicinity of the spray tip or inside the spray tip; and a distance indicator that provides indicia of the distance between the spray tip and the tissue but does not prevent positioning the spray tip closer to the tissue than a defined distance for the distance indicator.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: October 24, 2023
    Assignee: Ethicon, Inc.
    Inventors: Jerome Riebman, Leo B. Kriksunov, Robert J. Tannhauser
  • Publication number: 20230329686
    Abstract: The present invention is directed to a variable length applicator system for delivery of at least one medically useful liquid, comprising an elongated, telescopically extendable, variable length cannula having a liquid pump containing said liquid connected to said cannula at a proximal end, and a spray nozzle mounted on said cannula at a distal end; a coiled and extendable tubular conduit connected to and in fluid communication with, both said liquid pump and said spray nozzle; wherein an axial extension of said cannula is configured to cause a matching axial extension of said coiled tubular conduit.
    Type: Application
    Filed: April 19, 2022
    Publication date: October 19, 2023
    Applicant: Ethicon, Inc.
    Inventors: Jianxin Guo, Sridevi N. Dhanaraj, Leo Kriksunov
  • Patent number: 11766364
    Abstract: A surgical incision drape, comprises a flexible substantially flat areal substrate having an upper side and an opposing tissue-facing side, having a longitudinal axis and a pressure sensitive adhesive disposed on the tissue-facing side; at least one hollow microtubular compartment containing a flowable medical agent, said hollow microtubular compartment positioned to intersect the longitudinal axis and embedded into the substrate or positioned on the substrate.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: September 26, 2023
    Assignee: Ethicon, Inc.
    Inventors: Julian Quintero, Robert J. Tannhauser, Leo B. Kriksunov
  • Patent number: 11723654
    Abstract: A barbed suture including a body with barbs on the periphery, a pointed end, and an anchor at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and of varying distribution about the periphery of the suture body. Other anchor designs are provided. Methods of placing single-directional and bi-directional barbed sutures to approximate the tissue on each side of a wound and to position and support tissue in the absence of a wound, as in cosmetic surgery, are provided, and may include terminal J-stitches or S-stitches. Methods of placement may be made with sharp, pointed ends, which may be needles, or insertion devices. Sinusoidal patterns of sutures that have amplitudes generally perpendicular to the resultant holding force of the suture are provided.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: August 15, 2023
    Assignees: Ethicon, Inc., Cilag GmbH International
    Inventors: Gregory L. Ruff, Jeffrey C. Leung, Andrew Kaplan, Matthew A. Megaro, Stanton D. Batchelor