Abstract: Apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls, at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The loading sites are offset with respect to the wells. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells, and apparatus for electrophoresis separation having an electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in an alternating staggered format. A method for simultaneous loading of multiple samples into the electrophoresis apparatus.

Abstract: Apparatus for conducting electrophoresis separation therein. The apparatus includes a chamber having therein a body of separating gel for carrying therein an electrophoresis separation and electrodes for connecting the chamber to an external electrical power source, thereby driving the electrophoresis separation. According to the invention at least one of the electrodes also providing ions for driving the electrophoresis separation. In one preferred embodiment, the apparatus is a cassette substantially closed before, during and after electrophoresis separation. According to an aspect of the invention the pH in the body of separating gel is substantially constant during the electrophoresis separation.

Abstract: A substantially closed cassette for conducting therein electrophoresis separation which includes a closed chamber, the chamber includes therein a body of gel, at least one ion source having a volume smaller than the volume of the gel for providing ions for driving the electrophoresis separation and electrodes for connecting the cassette to an external electrical power source, thereby enabling to drive the electrophoresis separation.

Abstract: A substantially closed cassette for conducting therein electrophoresis separation which includes a closed chamber, the chamber includes therein a body of gel, means for providing ions for driving the electrophoresis separation and electrodes for connecting the cassette to an external electrical power source, thereby enabling to drive the electrophoresis separation.