Abstract: The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.
Type:
Grant
Filed:
March 2, 2001
Date of Patent:
November 15, 2011
Assignees:
Universite d'Angers, Ethypharm S.A.
Inventors:
Béatrice Heurtault, Patrick Saulnier, Jean-Pierre Benoit, Jacques-Emile Proust, Brigitte Pech, Joël Richard
Abstract: A process for separating and drying microparticles initially dispersed in a liquid phase, comprising the steps: placing a preparation comprising microparticles dispersed or suspended in a liquid phase in a filtration container placed inside a chamber; filtering a fraction of the liquid phase through the container in the chamber; and varying the temperature and the pressure throughout the chamber in order to freeze dry the filtered preparation in the container maintained in the chamber.
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