Abstract: A polysaccharide RDP substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the .sup.13 C-NMR spectrum depicted in FIG. 3 is obtained from rice bran by extraction.
Type:
Grant
Filed:
March 5, 1984
Date of Patent:
August 16, 1988
Assignees:
Sapparo Breweries Limited, Daicel Chemical Industries, Ltd., Etsuo Ito
Abstract: A polysaccharide RON substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the .sup.13 C-NMR spectrum depicted in FIG. 3 is obtained from rice bran by extraction and purification; and pharmacological composition containing said RON substance.
Type:
Grant
Filed:
August 12, 1985
Date of Patent:
August 9, 1988
Assignees:
Sapporo Breweries Limited, Daicel Chemical Industries, Ltd., Etsuo Ito
Abstract: A new substance having antitumor activity is obtained from an epidermal portion of rice. A substance called RBF-P is obtained by adding ethanol to an aqueous alkaline extract of rice bran, removing the insolubles and precipitating the substance by addition of an acid. This substance comprises an active substance called RBF-PM, which is insoluble in methanol, and an active substance called RBF-X, which is soluble in acetone. The substance RBF-PM is a protein containing extremely little cystine and said protein can suppress solid cancers of mice. The substance RBF-X is a mixture of hexane-solubles such as fatty acids and a hexane-insoluble called RBF-H. A synergistic suppressive action on ascites hepatoma of mice is exhibited by the combination of the RBF-H and the fatty acids.
Type:
Grant
Filed:
May 12, 1982
Date of Patent:
July 3, 1984
Assignees:
Daicel Chemical Industries, Ltd., Sapporo Breweries Ltd., Etsuo Ito
Abstract: A polysaccharide RBS substance having the ultraviolet absorption spectrum depicted in FIG. 1 and the infrared absorption spectrum depicited in FIG. 2 is obtained from rice bran by extraction with hot water. These substances have been tested for anti-tumor activity against Sarcoma 180 ascites tumor and against Ehrlich ascites tumor and were determined to have anti-tumor activity against these tested tumors.
Type:
Grant
Filed:
August 1, 1980
Date of Patent:
November 2, 1982
Assignees:
Sapporo Breweries Limited, Etsuo Ito, Daicel Chemical Industries, Ltd.