Patents Assigned to Euclises Pharmaceuticals, Inc.
  • No-releasing nitrooxy-chromene conjugates
    Patent number: 10266511
    Abstract: The present invention provides NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1) wherein R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical compositions comprising at least one compound o Formula (I); and methods useful for healing wounds, preventing and treating cancer and treating actinic keratosis, cystic fibrosis, and acne, using a compound of Formula (1).
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: April 23, 2019
    Assignee: EUCLISES PHARMACEUTICALS, INC.
    Inventors: John J. Talley, Eduardo J. Martinez
  • No-releasing guanidine-coxib anti-cancer agents
    Patent number: 9044464
    Abstract: The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, R11, Z and L are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: June 2, 2015
    Assignee: EUCLISES PHARMACEUTICALS, INC.
    Inventors: Eduardo J. Martinez, John J. Talley, Terri L. Boehm
  • No-releasing nonoate(nitrogen-bound)sulfonamide-linked-coxib anti-cancer agents
    Patent number: 8859781
    Abstract: The present invention provides NO-releasing NONOate(nitrogen bound)sulfonamide-linked-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, X, L, R2, R3, R4, and Z are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis or acne, using a compound of Formula (I).
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: October 14, 2014
    Assignee: Euclises Pharmaceuticals, Inc.
    Inventors: Eduardo J. Martinez, John J. Talley, Kevin D. Jerome, Terri L. Boehm