Patents Assigned to Eukarion, Inc.
  • TREATMENT OF SKIN DAMAGE
    Publication number: 20100267825
    Abstract: Methods and apparatus are disclosed for diagnosing and treating oxidative skin damage in a subject. The therapeutic method can comprise: (i) diagnosing a level of oxidative skin damage in a sample comprising stratum corneum of the subject; and (ii) recommending a therapeutic regime for treatment of oxidative skin damage in the subject, wherein said recommendation comprises a recommendation to administer a pharmaceutical formulation comprising an amount of one or more specific synthetic SOD/catalase mimetics sufficient to treat the level of oxidative skin damage of the subject as diagnosed. The diagnostic method can further include obtaining a sample from the stratum corneum of a subject; measuring the level of at least one oxidized substance in the sample; and comparing a detected level of the oxidized substance with a standard, whereby an elevated level of the oxidized substance is indicative of skin damage.
    Type: Application
    Filed: April 14, 2010
    Publication date: October 21, 2010
    Applicant: Eukarion, Inc.
    Inventor: Bernard Malfroy-Camine
  • Orally bioavailable low molecular weight metalloporphyrins as antioxidants
    Patent number: 7649091
    Abstract: The invention relates to compounds which are orally bioavailable water soluble metalloporphyrins. These compounds, e.g. represented by Structural Formula (I): wherein R1 and R2 are each independently lower alkyl, cycloalkyl, halogen substituted alkyl or substituted or unsubstituted phenyl groups, are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: January 19, 2010
    Assignee: Eukarion, Inc.
    Inventors: Bernard Meunier, Frederic Cosledan
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 7582786
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: September 1, 2009
    Assignee: Eukarion Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Cyclic salen-metal compounds as scavengers for oxygen radicals and useful as antioxidants in the treatment and prevention of diseases
    Patent number: 7122537
    Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: October 17, 2006
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 6900198
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: May 31, 2005
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases
    Patent number: 6589948
    Abstract: This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal compositions to treat or prevent a disease associated with cell or tissue damage produced by free radicals, such as superoxide.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: July 8, 2003
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Doctrow
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 6573257
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: June 3, 2003
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Bipyridine manganese complexes
    Patent number: 6541490
    Abstract: Compounds and methods of preparing compounds represented by structural formula (I): wherein X represents any suitable counter-anion; R1 and R2 independently represent hydrogen, C1-6 alkoxy or nitro; R3, R4, R5 and R6 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy; and R7, R8, R9 and R10 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy. Compounds represented by structural formula (I) are useful in treating or preventing free radical-associated diseases or conditions in mammals.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 1, 2003
    Assignee: Eukarion, Inc.
    Inventors: Ian Baxter Campbell, Ann Louise Walker, Philip Charles Box, Gerard Martin Paul Giblin, George Edward Tranter
  • Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
    Patent number: 6403788
    Abstract: This invention relates to compounds which are non-genotoxic metalloporphyrins. These compounds are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: June 11, 2002
    Assignee: Eukarion, Inc.
    Inventors: Bernard Meunier, Frédéric Cosledan
  • Bipyridine manganese complexes
    Patent number: 6177419
    Abstract: Compounds and methods of preparing compounds represented by structural formula (I): wherein X represents any suitable counter-anion; R1 and R2 independently represent hydrogen, C1-6 alkoxy or nitro; R3, R4, R5 and R6 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy; and R7, R8, R9 and R10 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy. Compounds represented by structural formula (I) are useful in treating or preventing free radical-associated diseases or conditions in mammals.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: January 23, 2001
    Assignee: Eukarion, Inc.
    Inventors: Ian Baxter Campbell, Ann Louise Walker, Philip Charles Box, Gerard Martin Paul Giblin, George Edward Tranter
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 6046188
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: April 4, 2000
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 5834509
    Abstract: This invention provides salen-manganese complexes and pharmaceutically acceptable compositions thereof useful as antioxidants and free radical scavengers.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 10, 1998
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 5827880
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: October 27, 1998
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 5696109
    Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
  • Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
    Patent number: 5403834
    Abstract: The invention provides antioxidant salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: April 4, 1995
    Assignee: Eukarion, Inc.
    Inventors: Bernard Malfroy-Camine, Michel Baudry