Abstract: Compounds of the formula ##STR1## wherein R.sup.3 is ethyl, n-propyl or n-butyl, andR.sup.8 is hydrogen, methyl or ethyl,exhibit bronchodilating activity with reduced side effects and increased half-like. A method of achieving bronchodilation with reduced undesired effects (diuresis, CNS activity), by administering the said compounds to a patient, is also provided.

Abstract: A vaginal pharmaceutical composition having sperm motility enhancing activity comprising a sperm motility enhancing amount of at least one sperm motility enhancing amino acid or amino acid salt in combination with a vaginally acceptable diluent or carrier.Preferred active materials are aspartic acid, glutamic acid, arginine, histidine, asparagine, glutamine and arginine aspartate. L-amino acids or salts are particularly preferred.The preparation may be in the form of a pessary, a cream, a liquid douche, a gel, an aerosol foam or a controlled delivery device.

Abstract: A contraceptive composition for application to the vagina of a female mammal comprising a contraceptive amount of a contraceptive combination, the combination containing a spermicidal or sperm-immobilizing polyethoxyethanol and a beta-adrenergic blocker (as herein before defined).The polyethoxyethanol may be, for example, an octoxynol or, which is preferred, a nonoxynol, especially nonoxynol-9. The beta-adrenergic blocker is preferably a spermicidal or sperm-immobilizing beta-adrenergic blocker, propranolol (in particular the d-isomer) being especially preferred.The composition may also contain a spermicidal or sperm-immobilizing preservative.

Abstract: Iodophor-containing suppositories are provided with improved rate of iodine release from the suppository. The suppository composition comprises an iodophor, a water soluble suppository base, at least one water soluble sugar having a molecular weight of between about 90 and 550, and water in an amount of at least about 30% by weight. The molecular weight of the sugar is preferably between about 150 and 370. The preferred iodophors are providone iodine and polydextrose iodine. The preferred suppository bases are gelling polysaccharides and the preferred sugars are monosaccharides, disaccharides and sugar alcohols. The rate of iodine release is improved because of the high concentration of water together with the presence of the low molecular weight sugar.

Abstract: A free flowing iodophor powder which can be used for the treatment of wounds and the like, is prepared by spraying a solution of the iodophor in an aqueous-alcoholic solvent having a boiling point at normal pressure of less than 100.degree. C. into a fluidized bed of a finely divided sugar. This results in the formation of a free flowing powder which is well tolerated upon application to wounds.

Abstract: New iodophor compositions are provided which are mixtures of polydextrose-iodine and polyvinylpyrrolidone-iodine. Such mixtures containing polydextrose-iodine and polyvinylpyrrolidone-iodine, wherein the ratio by weight of polydextrose to polyvinylpyrrolidone is between 20-80: 80-20, have an immediate bactericidal activity upon application and also a long lasting microbicidal activity. The immediate microbicidal acitivity is faster and more effective than by the use of either the polydextrose-iodine alone or the polyvinylpyrrolidone-iodine alone, and the effect is more long lasting than in the case of the use of either polydextrose-iodine alone or polyvinylpyrrolidone-iodine alone.

Abstract: Compounds of the formula ##STR1## wherein R.sup.3 is ethyl, n-propyl or n-butyl, andR.sup.8 is hydrogen, methyl or ethyl,exhibit bronchodilating activity with reduced side effects and increased half-life. A method of achieving bronchodilation with reduced undesired effects (diuresis, CNS activity), by administering the said compounds to a patient, is also provided.

Abstract: An antibacterial cream is provided which can be used for topical application in the treatment of burns and other skin disorders. The topical creams of the invention can be used without the need to destroy surface barriers and provide significant penetration into the wound. The creams of the present invention comprise a bacterial agent distributed in a cream base which contains 20-50% of at least one hydrocarbon component and at least one polyol moisturizing component, on a weight to weight basis.

Abstract: New iodophors are provided which exhibit effective degerming of skin, nucous membranes of animals and surfaces of inanimate objects and which provide broad spectrum microbicidal action without toxicity or irritation. The iodophors of the invention are complexes of iodine with polydextrose or with the polymer resulting from the copolymerization of sucrose and epichlorohydrin. The invention further relates to germicidal compositions containing such complexes and to methods of producing the complexes.

Abstract: A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.

Abstract: New iodophors are provided which exhibit effective degerming of skin, mucous membranes of animals and surfaces of inanimate objects and which provide broad spectrum microbicidal action without toxicity or irritation. The iodophors of the invention are complexes of iodine with polydextrose or with the polymer resulting from the copolymerization of sucrose and epichlorohydrin. The invention further relates to germicidal compositions containing such complexes and to methods of producing the complexes.

Abstract: Iodine-containing germicidal preparations are provided with assured control of the content of equilibrium iodine in aqueous solution to be between 1 and 20 ppm, preferably 2-15 ppm so as to provide predetermined germicidal activity. The invention further comprises the determination of the content of equilibrium iodine in an aqueous iodophor solution by subjecting such solution to several extractions with different amounts of a water immiscible solvent for iodine, determining the concentrations of the equilibrium iodine in each of the amounts of the water immiscible solvent and extrapolating the concentrations to a theoretical zero value which is a measure of the equilibrium iodine in the aqueous iodophor solution. The invention further comprises improved germicidal iodophor compositions comprising an iodophor, citric acid and iodate.

Abstract: The action of controlled release medications is extended by incorporation into the controlled release matrix for a medication a mixture of the salt form of the medication with the free base form of the medication in a proportion of a 75-25% by weight of the salt form to 25-75% by weight of the free base form, the weight amounts being calculated with respect to the active base.

Abstract: Sterilized povidone-iodine (polyvinylpyrrolidone-iodine) is obtained by irradiating povidone-iodine in the presence of iodide ions. Preferably the irradiation is effected in the presence of iodine and both iodide and iodate ions. The iodide ions, with or without iodate ions, have the effect of preventing the degradation of povidone-iodine and the gelation of iodine and povidone.

Abstract: Molecular coordination complexes are formed between a cellulose polymer and a non-polar solid aliphatic alcohol containing 8 to 18 carbon atoms optionally substituted with an aliphatic group containing 8 to 18 carbon atoms by solvating the polymer with a volatile polar solvent and reacting the solvated cellulose polymer directly with the aliphatic alcohol, preferably as a melt. The resulting composition may be dried. This constitutes the complex. The composition has utility as a matrix in controlled release formulations since it has a uniform porosity which may be varied.

Abstract: A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.