Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.
Type:
Grant
Filed:
July 28, 2020
Date of Patent:
April 23, 2024
Assignee:
EUROFINS LIFECODEXX GMBH
Inventors:
Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse
Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.
Type:
Grant
Filed:
June 11, 2018
Date of Patent:
October 3, 2023
Assignee:
EUROFINS LIFECODEXX GMBH
Inventors:
Sebastian Gromminger, Wera Hofmann, Hamed Said
Abstract: Methods for detecting a chromosomal aneuploidy in a foetus carried by a pregnant female are provided. Such methods are based on one or more of particular configurations and/or detections and/or analyses of two or more regions of DNA, including those that show differential methylation between DNA that originates from cells of a foetus (and/or the placenta of a foetus) and DNA of maternal origin. Such methods utilise a sample taken from a pregnant female, which sample comprises DNA that originates from cells of a foetus and/or the placenta of a foetus in admixture with differently methylated DNA of maternal origin. Such methods have diagnostic, prognostic and/or predictive utility; in particular for the detection/diagnosis of chromosomal aneuploidy, such as a trisomy, in a foetus, and/or for detecting an increased risk of a pregnant female suffering from or developing a pregnancy-associated medical condition.
Type:
Grant
Filed:
November 9, 2016
Date of Patent:
September 12, 2023
Assignee:
EUROFINS LIFECODEXX GMBH
Inventors:
Steffi Werler, Wera Hofmann, Matthias Sachse
Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
October 13, 2020
Assignee:
Eurofins LifeCodexx GmbH
Inventors:
Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse