Patents Assigned to European Molecular Biology Laboratory
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Publication number: 20160297763Abstract: The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: ApplicationFiled: April 6, 2016Publication date: October 13, 2016Applicants: F. HOFFMANN-LA ROCHE LTD, SAVIRA PHARMACEUTICALS GMBH, EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)Inventors: Dirk CLASSEN-HOUBEN, Andrea WOLKERSTORFER, Oliver SZOLAR, Mark SMITH, Sung-Sau SO, Stephen CUSACK, Thierry LANGER, Bruno GIETHLEN, Christophe MORICE, Céline MICHAUT-SIMON, Chloe ZUBIETA
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Patent number: 9434745Abstract: The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: GrantFiled: May 23, 2013Date of Patent: September 6, 2016Assignees: Savira pharmaceuticals GmbH, F. Hoffmann-La Roche AG, European Molecular Biology LaboratoryInventors: Andrea Wolkerstorfer, Oliver Szolar, Norbert Handler, Stephen Cusack, Thibault Sauvaitre, Céline Simon, Christophe Morice, Bruno Giethlen, Thierry Langer, Mark Smith, Sung-Sau So, Dirk Classen-Houben, Helmut Buschmann
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Patent number: 9359351Abstract: The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: GrantFiled: July 7, 2015Date of Patent: June 7, 2016Assignees: F. Hoffmann-La Roche AG, Savira pharmaceuticals GmbH, European Molecular Biology LaboratoryInventors: Tanja Schulz-Gasch, Robert Weikert, Werner Neidhart, Helmut Buschmann, Oliver Szolar, Andrea Wolkerstorfer, Norbert Handler, Franz-Ferdinand Roch, Stephen Cusack
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Publication number: 20160053241Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pandemic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: ApplicationFiled: June 26, 2015Publication date: February 25, 2016Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Stephen Cusack, Eva Kowalinski, Chloe Zubieta
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Patent number: 9199987Abstract: The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: GrantFiled: January 7, 2014Date of Patent: December 1, 2015Assignees: Savira pharmaceuticals GmbH, European Molecular Biology Laboratory, F. Hoffmann-La Roche AGInventors: Andrea Wolkerstorfer, Oliver Szolar, Norbert Handler, Helmut Buschmann, Stephen Cusack, Mark Smith, Sung-Sau So, Ronald Charles Hawley, Achyutharao Sidduri
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Publication number: 20150321190Abstract: The present invention relates to the automation of incubation, processing, harvesting and analysis of samples (15) in a multi-cell plate (1). In particular, a multi-cell plate (1) comprising a body (3) with a plurality of cells (5) is presented. Furthermore, an automated crystal harvesting and processing system (21) with a cutting unit (23), a fluid unit (29) and a removing device (33) is presented. The multi-cell plate (1) further comprises a sealing film (7) for sealing the cells (5) on a first side (9) of the body (3) and a sample film (11) for sealing the cells (5) on a second side (13) of the body (3). The sample film (11) is adapted for accommodating a biological material (15) for crystallization. Furthermore, the sample film (11) is of a thickness and composition that makes it compatible with x-rays and also with laser ablation.Type: ApplicationFiled: December 18, 2013Publication date: November 12, 2015Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Florent CIPRIANI, Jose Antonio MARQUEZ
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Patent number: 9181307Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pandemic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: GrantFiled: March 15, 2011Date of Patent: November 10, 2015Assignee: European Molecular Biology LaboratoryInventors: Stephen Cusack, Eva Kowalinski, Chloe Zubieta
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Publication number: 20150218539Abstract: The present invention relates to an activator of the calcineurin subunit A?1 isofomi (CnA?1) or of the C-terminal domain of the calcineurin subunit A?1 isofomi (CnA?1) for the production of a medicament for the modulation of myocardial growth without adversely affecting contractile function.Type: ApplicationFiled: August 16, 2013Publication date: August 6, 2015Applicant: EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Enrique Lara Pezzi, Marina López Olaneta, Maria Villalba Orero, Jesús Gómez Salinero, Nadia Rosenthal
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Publication number: 20150211682Abstract: The present invention relates to a pump (15) for pumping a coolant (9) within a Dewar vessel (1) and to a corresponding Dewar vessel (1) for storing samples in a coolant (9). The Dewar vessel (1) comprises a thermally insulated reservoir (3) for the coolant (9) and a sample vessel (11) provided separately and arranged in the thermally insulated reservoir (3). The reservoir (3) is connected to the sample vessel (11) in such a way that the level of coolant (9) is constant in the sample vessel (11). Pump (15) may help in keeping the level of coolant (9) in the sample vessel (11) constant. For this purpose the pump (15) comprises a chamber (17) with an inlet (19) and an outlet (21), a closing element (23) and a pressure increasing device (25). Therein, the inlet (19) is connectable to the reservoir (3) and the outlet (21) is connectable to a sample vessel (11) of the Dewar vessel (1).Type: ApplicationFiled: July 26, 2013Publication date: July 30, 2015Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Florent Cipriani, Franck Felisaz
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Patent number: 9045248Abstract: The present invention relates to soluble fragments of the Influenza virus RNA dependent RNA polymerase subunit PB2 and variants thereof, and crystallized complexes thereof comprising an RNA cap analog. This invention also relates to computational methods using the structural coordinates of said complex to screen for and design compounds that interact with the RNA cap binding pocket. In addition, this invention relates to methods identifying compounds that bind to PB2 polypeptide fragments comprising the RNA cap binding pocket, preferably inhibit the interaction with RNA caps or analogs thereof, by using said PB2 polypeptide fragments, preferably in a high-throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by negative-sense single stranded RNA viruses.Type: GrantFiled: October 9, 2008Date of Patent: June 2, 2015Assignee: European Molecular Biology LaboratoryInventors: Stephen Cusack, Delphine Gulligay, Darren Hart, Franck Tarendeau
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Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
Patent number: 9045486Abstract: The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: GrantFiled: January 7, 2014Date of Patent: June 2, 2015Assignees: Savira pharmaceuticals GmbH, European Molecular Biology Laboratory, F. Hoffman-La Roche AGInventors: Andrea Wolkerstorfer, Oliver Szolar, Norbert Handler, Helmut Buschmann, Stephen Cusack, Mark Smith, Sung-Sau So, Ronald Charles Hawley, Achyutharao Sidduri, Zhuming Zhang -
Publication number: 20150105315Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: ApplicationFiled: October 21, 2014Publication date: April 16, 2015Applicants: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), UNIVERSITY JOSEPH FOURIER FILIALE, Centre National de la Recherche Scientifique - Direction de la Politique IndustrielleInventors: Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Alexander Dias, Stephen Cusack
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Patent number: 8952039Abstract: The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: GrantFiled: January 7, 2014Date of Patent: February 10, 2015Assignees: European Molecular Biology Laboratory, F. Hoffmann-La Roche AG, Savira pharmaceuticals GmbHInventors: Andrea Wolkerstorfer, Oliver Szolar, Norbert Handler, Helmut Buschmann, Stephen Cusack, Mark Smith, Sung-Sau So, Ronald Charles Hawley
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Patent number: 8931357Abstract: A two-part coaxial needle for a pipetting device, in particular for use in microscopy of cell probes, makes it possible both to inject a liquid into a pipetting container and to remove by suction a liquid from the pipetting container. Both the drive for lowering the coaxial needle into the pipetting container, and injection and removal by suction of the liquid take place pneumatically by way of only one pressure source. The design of the coaxial needle and of the drive systems makes possible fast and reliable pipetting with high metering accuracy and a particularly compact pipetting unit which without mutual interference can be used with a multitude of widely-used microscope types.Type: GrantFiled: December 3, 2009Date of Patent: January 13, 2015Assignee: EMBL European Molecular Biology LaboratoryInventors: Siegfried Winkler, Christian Conrad
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Patent number: 8921388Abstract: The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: GrantFiled: August 5, 2013Date of Patent: December 30, 2014Assignees: European Molecular Biology Laboratory, F. Hoffmann-La Roche AG, Savira pharmaceuticals GmbHInventors: Helmut Buschmann, Andrea Wolkerstorfer, Oliver Szolar, Norbert Handler, Stephen Cusack, Mark Smith, Sung-Sau So
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Publication number: 20140349931Abstract: The present invention describes methods for determining the risk that a breast precursor lesion will progress to invasive breast cancer and/or the risk of recurrent non-invasive disease in a patient, comprising detecting the presence and/or level of PAPPA and/or PAPPA functional activity in a breast tissue sample obtained from the patient, wherein if PAPPA is not present, or is present at a reduced amount compared to a control, there is the risk of progression to invasive cancer and/or the risk or recurrent disease. The present invention also enables the chemosensitisation of mitotically delayed breast cancer cells to anti-proliferative agents, preferably anti-mitotic agents, by restoring normal progression through mitosis. In this embodiment a first drug is applied to release breast cancer cells from the mitotic block and, sequentially, a second drug affecting proliferating cells is administered for cancer cell killing.Type: ApplicationFiled: December 20, 2012Publication date: November 27, 2014Applicants: THE EUROPEAN MOLECULAR BIOLOGY LABORATORY, FAHY GURTEEN LABORATORIES LTD., UCL BUSINESS PLCInventors: Jan Ellenberg, Beate Neumann, Marco Loddo, Gareth Williams, Kai Stoeber
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Patent number: 8754012Abstract: The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate protein in the library to a peptide substrate and identifying cells that express soluble candidate protein by detecting enzymatic modification of the peptide substrate.Type: GrantFiled: September 5, 2005Date of Patent: June 17, 2014Assignee: European Molecular Biology LaboratoryInventor: Darren James Hart
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Publication number: 20140042339Abstract: A microscope and imaging method in which a layer of the sample is illuminated by a thin strip of light and the sample is viewed perpendicular to the plane of the strip of light. The depth of the strip of light thus essentially determines the depth of focus of the system. To record the image, the object is displaced through the strip of light, which remains fixed in relation to the detector, and fluorescent and/or diffused light is captured by a planar detector. Objects that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images.Type: ApplicationFiled: January 22, 2013Publication date: February 13, 2014Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)Inventors: Ernst H.K. Stelzer, Sebastian Enders, Jan Huisken, Steffen Lindek, James H. Swoger
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Publication number: 20140038990Abstract: The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: ApplicationFiled: August 5, 2013Publication date: February 6, 2014Applicants: SAVIRA PHARMACEUTICALS GMBH, EUROPEAN MOLECULAR BIOLOGY LABORATORY, F. HOFFMANN-LA ROCHE AGInventors: Helmut BUSCHMANN, Andrea WOLKERSTORFER, Oliver SZOLAR, Norbert HANDLER, Stephen CUSACK, Mark SMITH, Sung-Sau SO
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Publication number: 20130317022Abstract: The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: ApplicationFiled: May 23, 2013Publication date: November 28, 2013Applicants: European Molecular Biology Laboratory, F. Hoffmann-La Roche AGInventors: Andrea WOLKERSTORFER, Oliver SZOLAR, Norbert HANDLER, Stephen CUSACK, Thibault SAUVAITRE, Céline SIMON, Christophe MORICE, Bruno GIETHLEN, Thierry LANGER, Mark SMITH, Sung-Sau SO, Dirk CLASSEN-HOUBEN, Helmut BUSCHMANN