Patents Assigned to Euroscreen s.a.
  • Chiral -acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Patent number: 9475814
    Abstract: The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: October 25, 2016
    Assignee: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Guillaume Dutheuil, Graeme L. Fraser, Marie-Odile Roy, Mohamed El Bousmaqui, Frederic Batt
  • ORGANIC COMPOUNDS
    Publication number: 20160274110
    Abstract: The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Application
    Filed: October 23, 2014
    Publication date: September 22, 2016
    Applicants: NOVARTIS AG, EUROSCREEN S.A.
    Inventors: Frederic BASSILANA, Birgit Uta BAUMGARTEN, Nathalie Marie-Therese CARTE, Michel DETHEUX, Rocco FALCHETTO, Sebastien HANNEDOUCHE, Vincent LANNOY, Keith MANSFIELD, Klaus Peter SEUWEN, Thomas Laurent Henri Suply
  • NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
    Patent number: 8871761
    Abstract: The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 28, 2014
    Assignee: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Marie-Odile Roy, Graeme Lovat Fraser, Guillaume Dutheuil
  • PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43)
    Publication number: 20130023539
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: June 18, 2012
    Publication date: January 24, 2013
    Applicant: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • NOVEL NK-3 RECEPTOR SELECTIVE ANTAGONIST COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN NK-3 RECEPTORS MEDIATED DISORDERS
    Publication number: 20130023530
    Abstract: The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.
    Type: Application
    Filed: September 26, 2012
    Publication date: January 24, 2013
    Applicant: Euroscreen S.A.
    Inventor: Euroscreen S.A.
  • Methods of making an antibody that binds a chemerin polypeptide
    Patent number: 8030453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: October 4, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
    Publication number: 20110230477
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.
    Type: Application
    Filed: December 7, 2009
    Publication date: September 22, 2011
    Applicant: Euroscreen S.A.
    Inventors: Hamid Hoveyda, Cyrille Evangelos Brantis, Guillaume Dutheuil, Ludivine Zoute, Didier Schils, Jerome Bernard
  • Nucleic acids encoding ChemerinR ligands
    Patent number: 8003347
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: August 23, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • Monoclonal antibodies that bind Chemerin polypeptide
    Patent number: 7858755
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: December 28, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel LePoul, Cecile Loison, Frédéric Ooms
  • Nucleic acids encoding a heme binding protein polypeptide
    Patent number: 7842795
    Abstract: The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of FPRL2 polypeptide signalling.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: November 30, 2010
    Assignee: Euroscreen S.A.
    Inventors: Isabelle Migeotte, Marc Parmentier, David Communi, Maryse Brait
  • Methods of identifying modulators of ChemerinR polypeptides
    Patent number: 7842453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 30, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • Ligand for G-protein coupled receptor GPR72 and uses thereof
    Patent number: 7824866
    Abstract: The present invention relates to methods, reagents and kits for detecting of GPR72 polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against GPR72. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of GPR72 polypeptide signalling.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: November 2, 2010
    Assignee: Euroscreen S.A.
    Inventors: Sebastien Hannedouche, Marie-Odile Roy
  • Compositions comprising a ligand of Chemerin R
    Patent number: 7666401
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Method of screening for modulators of HIV infection
    Patent number: 7662548
    Abstract: The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: February 16, 2010
    Assignee: Euroscreen S.A. ICOS Corporation
    Inventors: Patrick W. Gray, Vicki L. Schweickart, Carol J. Raport
  • Functional antibodies that specifically bind to the Chemerin receptor
    Patent number: 7582734
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 1, 2009
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Compositions and Methods Comprising a Ligand of ChemerinR
    Publication number: 20090081729
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Use of Piperidine Derivatives as Agonists of Chemokine Receptor Activity
    Publication number: 20090054451
    Abstract: The present invention is directed to novel piperidine derivatives and to the use of piperidine derivatives of formula I as agonists of chemokine receptor activity.
    Type: Application
    Filed: August 4, 2008
    Publication date: February 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Jacques Huck, Frederic Ooms, Christian Tyrchan, Hamid R. Hoveyda
  • Novel Piperidine-4-Acetic Acid Derivatives and Their Use
    Publication number: 20090048291
    Abstract: The present invention is directed to compounds of formula I compositions comprising them and their use.
    Type: Application
    Filed: August 4, 2008
    Publication date: February 19, 2009
    Applicant: Euroscreen S.A.
    Inventors: Jacques Huck, Frederic Ooms, Julien Parcq, Regereau Yannick, Hamid R. Hoveyda, Guillaume Dutheuil
  • Antibody that specifically binds to Chemerin receptor ligand precursor
    Patent number: 7470772
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: December 30, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
    Patent number: 7422846
    Abstract: The present invention is related to a method of detecting the dysregulation of GPR86 activity.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: September 9, 2008
    Assignee: Euroscreen S.A
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillian, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems