Patents Assigned to Euroscreen s.a.
  • Chiral -acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Patent number: 9475814
    Abstract: The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: October 25, 2016
    Assignee: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Guillaume Dutheuil, Graeme L. Fraser, Marie-Odile Roy, Mohamed El Bousmaqui, Frederic Batt
  • ORGANIC COMPOUNDS
    Publication number: 20160274110
    Abstract: The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Application
    Filed: October 23, 2014
    Publication date: September 22, 2016
    Applicants: NOVARTIS AG, EUROSCREEN S.A.
    Inventors: Frederic BASSILANA, Birgit Uta BAUMGARTEN, Nathalie Marie-Therese CARTE, Michel DETHEUX, Rocco FALCHETTO, Sebastien HANNEDOUCHE, Vincent LANNOY, Keith MANSFIELD, Klaus Peter SEUWEN, Thomas Laurent Henri Suply
  • NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
    Patent number: 8871761
    Abstract: The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 28, 2014
    Assignee: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Marie-Odile Roy, Graeme Lovat Fraser, Guillaume Dutheuil
  • NOVEL NK-3 RECEPTOR SELECTIVE ANTAGONIST COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN NK-3 RECEPTORS MEDIATED DISORDERS
    Publication number: 20130023530
    Abstract: The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.
    Type: Application
    Filed: September 26, 2012
    Publication date: January 24, 2013
    Applicant: Euroscreen S.A.
    Inventor: Euroscreen S.A.
  • PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43)
    Publication number: 20130023539
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: June 18, 2012
    Publication date: January 24, 2013
    Applicant: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Methods of making an antibody that binds a chemerin polypeptide
    Patent number: 8030453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: October 4, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
    Publication number: 20110230477
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.
    Type: Application
    Filed: December 7, 2009
    Publication date: September 22, 2011
    Applicant: Euroscreen S.A.
    Inventors: Hamid Hoveyda, Cyrille Evangelos Brantis, Guillaume Dutheuil, Ludivine Zoute, Didier Schils, Jerome Bernard
  • Nucleic acids encoding ChemerinR ligands
    Patent number: 8003347
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: August 23, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • Monoclonal antibodies that bind Chemerin polypeptide
    Patent number: 7858755
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: December 28, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel LePoul, Cecile Loison, Frédéric Ooms
  • Methods of identifying modulators of ChemerinR polypeptides
    Patent number: 7842453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 30, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • Nucleic acids encoding a heme binding protein polypeptide
    Patent number: 7842795
    Abstract: The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of FPRL2 polypeptide signalling.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: November 30, 2010
    Assignee: Euroscreen S.A.
    Inventors: Isabelle Migeotte, Marc Parmentier, David Communi, Maryse Brait
  • Ligand for G-protein coupled receptor GPR72 and uses thereof
    Patent number: 7824866
    Abstract: The present invention relates to methods, reagents and kits for detecting of GPR72 polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against GPR72. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of GPR72 polypeptide signalling.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: November 2, 2010
    Assignee: Euroscreen S.A.
    Inventors: Sebastien Hannedouche, Marie-Odile Roy
  • Compositions comprising a ligand of Chemerin R
    Patent number: 7666401
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Functional antibodies that specifically bind to the Chemerin receptor
    Patent number: 7582734
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 1, 2009
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Compositions and Methods Comprising a Ligand of ChemerinR
    Publication number: 20090081729
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Use of Piperidine Derivatives as Agonists of Chemokine Receptor Activity
    Publication number: 20090054451
    Abstract: The present invention is directed to novel piperidine derivatives and to the use of piperidine derivatives of formula I as agonists of chemokine receptor activity.
    Type: Application
    Filed: August 4, 2008
    Publication date: February 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Jacques Huck, Frederic Ooms, Christian Tyrchan, Hamid R. Hoveyda
  • Novel Piperidine-4-Acetic Acid Derivatives and Their Use
    Publication number: 20090048291
    Abstract: The present invention is directed to compounds of formula I compositions comprising them and their use.
    Type: Application
    Filed: August 4, 2008
    Publication date: February 19, 2009
    Applicant: Euroscreen S.A.
    Inventors: Jacques Huck, Frederic Ooms, Julien Parcq, Regereau Yannick, Hamid R. Hoveyda, Guillaume Dutheuil
  • Antibody that specifically binds to Chemerin receptor ligand precursor
    Patent number: 7470772
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: December 30, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Isolated ligand of ChemerinR
    Patent number: 7419658
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: September 2, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Methods of identifying modulators of ligand binding to ChemerinR polypeptides
    Patent number: 7332291
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 19, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valérie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stéphane Brézillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul