Abstract: The present invention provides acidic fibroblast growth factor (aFGF) composition, comprising: (i) aFGF of SEQ ID NO: 1, (ii) aFGF of SEQ ID NO: 1 having an N-terminal phosphogluconoylation, (iii) aFGF of SEQ ID NO: 1 having an N-terminal gluconoylation, (iv) aFGF of SEQ ID NO: 2 and (v) aFGF of SEQ ID NO: 3, or a combination thereof. Also provided is a modified acidic fibroblast growth factor (aFGF) which has an N-terminal phosphogluconoylation or gluconoylation.
Abstract: The present invention provides for treating neurodegeneration caused by nerve compression syndrome or entrapment neuropathy comprising administering human acidic fibroblast growth factor (aFGF), fibrinogen, aprotinin and divalent calcium ions to a subject in need thereof.
Type:
Grant
Filed:
August 13, 2010
Date of Patent:
December 1, 2015
Assignee:
Eu Sol Biotech Co., Ltd.
Inventors:
Henrich Cheng, Ming-Jei Lo, Yee-Chiang Liu
Abstract: The present invention provides a method for treating brain injury or stroke in a subject in need thereof, comprising implanting a microdialysis probe into the injury or insult core of the subject and perfusing the probe with an oncotic agent dissolved in a physiologically acceptable buffer, wherein the microdialysis probe comprises a dialysis membrane with a molecular weight cutoff less than the molecular weight of the oncotic agent.
Type:
Application
Filed:
October 8, 2013
Publication date:
June 5, 2014
Applicant:
EU SOL Biotech Co., Ltd.
Inventors:
HENRICH CHENG, MAY-JYWAN TSAI, SHIANG-SUO HUANG, SHIH-LING HUANG
Abstract: An modified peptide of human acidic fibroblast growth factor (aFGF), comprising a native human aFGF shortened by a deletion of a deletion of 20 amino acids from N-terminal of the native human aFGF, and an addition of Alanine (Ala) before the shortened native aFGF is provided.
Abstract: The present invention provides for treating neurodegeneration caused by nerve compression syndrome or entrapment neuropathy comprising administering human acidic fibroblast growth factor (aFGF), fibrinogen, aprotinin and divalent calcium ions to a subject in need thereof.
Type:
Application
Filed:
August 13, 2010
Publication date:
February 17, 2011
Applicant:
EU SOL BIOTECH CO., LTD.
Inventors:
HENRICH CHENG, MING-JEI LO, YEE-CHIANG LIU
Abstract: An modified peptide of human acidic fibroblast growth factor (aFGF), comprising a native human aFGF shortened by a deletion of a deletion of 20 amino acids from N-terminal of the native human aFGF, and an addition of alanine (Ala) before the shortened native aFGF is provided.