Patents Assigned to EUSTRALIS PHARMACEUTICALS LIMITED
  • PARENTERAL FORMULATIONS AND USES THEREOF
    Publication number: 20240091221
    Abstract: This invention relates generally to therapeutic parenteral formulations comprising particular substituted pyridine based compounds, their manufacture, and methods and uses of said formulations in treating elevated intracranial pressure for indications such as, but not limited to, traumatic brain injury and stroke.
    Type: Application
    Filed: September 26, 2023
    Publication date: March 21, 2024
    Applicant: Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro)
    Inventors: Pierre VANKAN, Andreea SASARMAN, Grasiela Bourscheit WILLMBRINK
  • Parenteral formulations and uses thereof
    Patent number: 11801244
    Abstract: This invention relates generally to therapeutic parenteral formulations comprising particular substituted pyridine based compounds, their manufacture, and methods and uses of said formulations in treating elevated intracranial pressure for indications such as, but not limited to, traumatic brain injury and stroke.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: October 31, 2023
    Assignee: Eustralis Pharmaceuticals Limited
    Inventors: Pierre Vankan, Andreea Sasarman, Grasiela Bourscheit Willmbrink
  • Therapeutic Methods And Uses Thereof
    Publication number: 20230124548
    Abstract: This invention relates generally to therapeutic methods comprising the delivery of particular substituted pyridine based compounds for lowering intracranial pressure (ICP), in treating substance P mediated pathways in the brain such as, but not limited to concussion, post-concussive (or post-concussion) syndrome (PCS), chronic traumatic encephalopathy (CTE), traumatic brain injury (TBI) and stroke.
    Type: Application
    Filed: August 21, 2020
    Publication date: April 20, 2023
    Applicant: Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro)
    Inventors: Pierre Vankan, Peter Pursey
  • Method for preventing and/or treating chronic traumatic encephalopathy-i
    Patent number: 11426384
    Abstract: The present invention relates to a method of preventing and/or treating chronic traumatic encephalopathy.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: August 30, 2022
    Assignee: EUSTRALIS PHARMACEUTICALS LIMITED (Trading as Pressure Neuro)
    Inventor: Robert Vink
  • METHOD FOR PREVENTING AND/OR TREATING CHRONIC TRAUMATIC ENCEPHALOPATHY-I
    Publication number: 20220218663
    Abstract: The present invention relates to a method of preventing and/or treating chronic traumatic encephalopathy.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 14, 2022
    Applicant: EUSTRALIS PHARMACEUTICALS LIMITED (trading as Pressura Neuro)
    Inventor: Robert Vink
  • Chemical Compound Manufacture, New Salt Form, And Therapeutic Uses Thereof
    Publication number: 20220073467
    Abstract: There is disclosed a method of preparing a compound of Formula (1), or a salt thereof (1) the method comprising: a) treating a compound of Formula (2) sequentially with o-tolylmagnesium chloride, N-methylpiperazine and iodine, under conditions sufficient to obtain a compound of Formula (3) b) treating the compound of Formula (3) from step a) with 3,5-bis(trifluoromethyl)benzyl bromide and a suitable base, under conditions sufficient to obtain a compound of Formula (1).
    Type: Application
    Filed: December 24, 2019
    Publication date: March 10, 2022
    Applicant: Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro)
    Inventor: Angela Liakatos
  • METHOD FOR PREVENTING AND/OR TREATING CHRONIC TRAUMATIC ENCEPHALOPATHY-I
    Publication number: 20210100773
    Abstract: The present invention relates to a method of preventing and/or treating chronic traumatic encephalopathy.
    Type: Application
    Filed: July 31, 2020
    Publication date: April 8, 2021
    Applicant: EUSTRALIS PHARMACEUTICALS LIMITED (Trading as Pressura Neuro)
    Inventor: Robert Vink
  • Parenteral Formulations And Uses Thereof
    Publication number: 20200368226
    Abstract: This invention relates generally to therapeutic parenteral formulations comprising particular substituted pyridine based compounds, their manufacture, and methods and uses of said formulations in treating elevated intracranial pressure for indications such as, but not limited to, traumatic brain injury and stroke.
    Type: Application
    Filed: February 1, 2019
    Publication date: November 26, 2020
    Applicant: Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro)
    Inventors: Pierre Vankan, Andreea Sasarman, Grasiela Bourscheit Willmbrink
  • Oral Formulations And Uses Thereof
    Publication number: 20200368166
    Abstract: Disclosed are therapeutic oral formulations comprising particular substituted pyridine based compounds, their manufacture, and methods and uses of the formulations in treating substance P mediated pathways in the brain such as elevated intracranial pressure or the modification of expression of (hyper)-phosphorylated tau protein (?) in the brain for indications such as, but not limited to concussion, post-concussive (or post-concussion) syndrome (PCS), chronic traumatic encephalopathy (CTE), traumatic brain injury (TBI) and stroke.
    Type: Application
    Filed: February 1, 2019
    Publication date: November 26, 2020
    Applicant: Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro)
    Inventors: Pierre Vankan, Andreea Sasarman, Grasiela Bourscheit Willmbrink
  • Method for preventing and/or treating chronic traumatic encephalopathy-I
    Patent number: 10729677
    Abstract: The present invention relates to a method of preventing and/or treating chronic traumatic encephalopathy.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: August 4, 2020
    Assignee: EUSTRALIS PHARMACEUTICAL LIMITED (TRADING AS PRESSURA NEURO)
    Inventor: Robert Vink
  • Brain, spinal, and nerve injury treatment
    Patent number: 10201568
    Abstract: A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: February 12, 2019
    Assignee: EUSTRALIS PHARMACEUTICALS LIMITED
    Inventors: Alan John Nimmo, Robert Vink
  • METHOD FOR PREVENTING AND/OR TREATING CHRONIC TRAUMATIC ENCEPHALOPATHY-II
    Publication number: 20160136160
    Abstract: The present invention relates to a method of preventing and/or treating chronic traumatic encephalopathy by administering to a subject N-(3,5-Bis-trifluoromethyl-benzyl)-N-methyl-6-(piperazin-1-yl)-4-o-tolyl nicotinamide or 4-alkyl-piperazin-1-yl derivatives thereof.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 19, 2016
    Applicant: EUSTRALIS PHARMACEUTICALS LIMITED (trading as PresSura Neuro)
    Inventor: Robert Vink
  • Brain, spinal and nerve injury treatment
    Patent number: 9186404
    Abstract: A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance P receptor antagonist and a magnesium compound.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: November 17, 2015
    Assignee: EUSTRALIS PHARMACEUTICALS LIMITED
    Inventors: Alan John Nimmo, Robert Vink