Abstract: The invention relates to a process for the asymmetric transfer hydrogenation of a ketone substrate to produce as chiral secondary alcohol with an ee of greater than 85% in which an enantio-enriched chiral catalyst containing ruthenium or rhodium is used with a hydrogen donor and in which an anion exchange resin is used as a base.
Type:
Grant
Filed:
April 14, 2011
Date of Patent:
March 10, 2015
Assignee:
Euticals GmbH
Inventors:
Richard Wisdom, Joerg Jung, Andreas Meudt
Abstract: The present invention relates to a method for producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide), by methylation of (R)-2-acetamino-2-N-benzyl-3-hydroxy-propionamide (V), in which the methylation is carried out at a temperature below 20° C.
Type:
Grant
Filed:
October 17, 2011
Date of Patent:
December 3, 2013
Assignee:
Euticals GmbH
Inventors:
Richard Wisdom, Joerg Jung, Andreas Meudt
Abstract: The invention relates to a process for the asymmetric transfer hydrogenation of a ketone substrate to produce as chiral secondary alcohol with an ee of greater than 85% in which an enantio-enriched chiral catalyst containing ruthenium or rhodium is used with a hydrogen donor and in which an anion exchange resin is used as a base.
Type:
Application
Filed:
April 14, 2011
Publication date:
May 16, 2013
Applicant:
Euticals GmbH
Inventors:
Richard Wisdom, Joeng Jung, Andress Meudt
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