Abstract: A method for predicting the onset of any (NO)-related negative influence of hemolysis, such as pain or the likely occurrence of a stroke, in a human patient by detecting abnormal levels of hemolysis, through the measurement of one or more breath gas concentrations.

Abstract: A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.

Abstract: A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.

Abstract: Apparatus (10) for evoking and recording bio-potentials from a human subject and methods of use are described. The apparatus (10) includes a flexible member (18) with a layer of conductive material (12) disposed thereon for contacting a skin surface on the human subject. The dimensions and shape of the flexible member (18) are adapted for conforming contact between the conductive material (12) and the skin surface. A stimulus delivery element (28) is coupled to the flexible member (18) for delivering a sensory stimulus to the subject to evoke bio-potentials, which are detected and received through the layer of conductive material (12).

Abstract: An apparatus for monitoring bioelectric signals of a patient which includes a processing system and an interface for receiving external electrical signals representative of a condition of the patient. The interface is configured to convey a representation of the received external signals to the processing system, and includes a common mode cancellation amplifier circuit which is adapted to reduce common mode signal noise present in the external signals.

Abstract: A method and apparatus for de-noising weak bio-signals having a relatively low signal to noise ratio utilizes an iterative process of wavelet de-noising a data set comprised of a new set of frames of wavelet coefficients partially generated through a cyclic shift algorithm. The method preferably operates on a data set having 2N frames, and the iteration is performed N?1 times. The resultant wavelet coefficients are then linearly averaged and an inverse discrete wavelet transform is performed to arrive at the de-noised original signal. The method is preferably carried out in a digital processor.

Abstract: A system and method for performing monitoring of anesthesia and sedation in a patient includes a patient sensor integrating EEG, pulse oximetry, ECG, and AEP signal inputs, integrated analog hardware, digital hardware, and a digital signal processing system that executes a selected algorithm to process received signals representative of a patient's condition, and which generates an index value associated with said patient condition.

Abstract: A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.

Abstract: A method and apparatus for de-noising weak bio-signals having a relatively low signal to noise ratio utilizes an iterative process of wavelet de-noising a data set comprised of a new set of frames of wavelet coefficients partially generated through a cyclic shift algorithm. The method preferably operates on a data set having 2N frames, and the iteration is performed N?1 times. The resultant wavelet coefficients are then linearly averaged and an inverse discrete wavelet transform is performed to arrive at the de-noised original signal. The method is preferably carried out in a digital processor.

Abstract: Apparatus (10) for evoking and recording bio-potentials from a human subject and methods of use are described. The apparatus (10) includes a flexible member (18) with a layer of conductive material (12) disposed thereon for contacting a skin surface on the human subject. The dimensions and shape of the flexible member (18) are adapted for conforming contact between the conductive material (12) and the skin surface. A stimulus delivery element (28) is coupled to the flexible member (18) for delivering a sensory stimulus to the subject to evoke bio-potentials, which are detected and received through the layer of conductive material (12).

Abstract: A method and apparatus for de-noising weak bio-signals having a relatively low signal to noise ratio utilizes an iterative process of wavelet de-noising a data set comprised of a new set of frames of wavelet coefficients partially generated through a cyclic shift algorithm. The method preferably operates on a data set having 2N frames, and the iteration is performed N?1 times. The resultant wavelet coefficients are then linearly averaged and an inverse discrete wavelet transform is performed to arrive at the de-noised original signal. The method is preferably carried out in a digital processor.

Abstract: A method and apparatus for de-noising weak bio-signals having a relatively low signal to noise ratio utilizes an iterative process of de-noising a data set comprised of a new set of frames. The method separately performs a non-linear de-noising operation on each of the component frames and combines the resultant de-noised frames to form a combined resultant de-noised input signal. The method is preferably carried out in a digital processor.

Abstract: Handheld apparatus (100), and method for comprehensive hearing testing with pass/refer results applicable for large scale neonatal screening, adult screening, full hearing diagnostic is disclosed. The apparatus (100) contains a signal processor (1), integral ear probe (150), and remote ear, and scalp probes (104) all packaged as a single handheld battery operated device (100). The apparatus (100) preferably performs a battery of tests, either independently or combined: oto-acoustic measurements utilizing a novel digital signal processing method for evoked oto-acoustic signal processing, auditory brain stem response test, tympanometry, and oto-reflectance. Algorithms for automatic test sequence, and pass/refer indication for the tests are provided.

Abstract: A portable hand-held electrical testing device including a processor housed within an enclosure. The processor is configured to operate on commands by a user to process sub-microvolt electrical signals received through an input/output interface. The input/output interface includes a capacitive coupled amplifier with adjustable gain settings. Onboard memory linked to the processor stores processing data and instructions. A display device is mounted to said enclosure and is operatively connected to the processor to display processing results in real time.