Abstract: The present application provides methods of administering an IL-22 dimer to an individual, such as a human individual, comprising intravenously administering to the individual an effective amount of an IL-22 dimer, wherein the amount of the IL-22 dimer is about 2 ?g/kg to about 200 ?g/kg (such as about 10 ?g/kg to about 45 ?g/kg), as well as methods of treating diseases by following such administration methods. Also provided are kits, unit dosages, and articles of manufacture for use in any one of the methods described herein.
Abstract: The present invention relates to methods of preventing and/or treating necrotizing enterocolitis or other intestinal inflammations using an IL-22, a dimer or a multimer thereof.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
November 29, 2022
Assignees:
Evive Biotechnology (Shanghai) Ltd, University Of Pittsburgh—Of The Commonwealth System Of Higher Education
Inventors:
Jay Kennedy Kolls, Misty Lynn Good, Xiaoqiang Yan