Abstract: An intestine-specific partial agonists of farnesoid X receptor (FXR) is disclosed, along with methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with FXR activity.
Abstract: Disclosed is a pharmaceutical composition containing EW-7197 (2-fluoro-N-((5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl)methyl)aniline), a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient useful in the treatment and prevention of a disease state mediated by transforming growth factor-? (TGF-?) type I receptor (ALK5).