Patents Assigned to Exact Sciences Corporation
  • Apparatus and method for drug screening
    Patent number: 6849403
    Abstract: The present invention provides kits and methods for screening drugs and drug candidates for activity by determining the presence or absence of high integrity nucleic acid in a sample.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 1, 2005
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Methods for detecting contamination in molecular diagnostics using PCR
    Patent number: 6844155
    Abstract: The invention provides methods for detecting contamination in a PCR reaction. Methods of the invention are especially useful for detection of contamination in heterogeneous samples containing a rare nucleic acid to be detected.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: January 18, 2005
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
    Patent number: 6818404
    Abstract: The invention provides amplification-based methods for detecting hypermethylated nucleic acid in heterogeneous biological samples, e.g., stool. A screening procedure based on the detection of hypermethylation, preferably at multiple genes, provides a means for detecting various diseases, e.g., colorectal cancer. By using chimeric primers that contain a 5′ non-specific portion, the specificity and efficiency of the nucleic acid amplification is improved. Methods of the invention are especially useful in detection of rare events in a heterogeneous sample.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: November 16, 2004
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Method for alteration detection
    Patent number: 6750020
    Abstract: Methods are provided for detecting an alteration in a target nucleic acid. Methods of the invention are useful for detecting and identifying mutations that are indicative of disease or the predisposition for disease.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: June 15, 2004
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Primer extension methods for detecting nucleic acids
    Publication number: 20040110162
    Abstract: Methods are provided for selective nucleic acid sequence detection in single base primer extension reactions of high sensitivity. These methods are useful for detecting small amounts of mutant nucleic acid in a heterogeneous biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.
    Type: Application
    Filed: February 5, 2003
    Publication date: June 10, 2004
    Applicant: EXACT SCIENCES CORPORATION
    Inventors: Anthony P. Shuber, Stanley N. Lapidus
  • Methods for analysis of molecular events
    Publication number: 20030203382
    Abstract: Methods and compositions are provided for detecting the presence of nucleic acid sequence variants in a subpopulation of nucleic acid molecules in a biological sample. These methods are particularly useful for identifying individuals with mutations indicative of cancer.
    Type: Application
    Filed: February 18, 2003
    Publication date: October 30, 2003
    Applicant: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, Lisa Kann, Duncan Whitney
  • Slotted electrophoresis gel composition and methods of use thereof
    Publication number: 20030170635
    Abstract: A slotted electrophoresis gel composition and methods of use are disclosed in the present invention. The invention also describes an apparatus that is used to produce a slotted electrophoresis gel composition.
    Type: Application
    Filed: March 1, 2002
    Publication date: September 11, 2003
    Applicant: EXACT Sciences Corporation
    Inventors: Philip W. Hammond, Christopher P. Adams, Ezra S. Abrams, T. Christian Boles
  • Methods for disease detection
    Patent number: 6586177
    Abstract: The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: July 1, 2003
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Methods for preserving DNA integrity
    Patent number: 6551777
    Abstract: Methods for extracting DNA from a biological sample that result in a higher yield of target DNA than conventional methods. More particularly, methods for extracting DNA include exposing the biological sample to inhibitors of DNA degradation.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: April 22, 2003
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, Frederick A. Huntress, Jr., James K. Moore
  • Methods for detecting mutations using primer extension for detecting disease
    Patent number: 6503718
    Abstract: Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: January 7, 2003
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, William Pierceall, Steven J. Laken
  • Methods for detecting mutations using primer extension for detecting disease
    Patent number: 6498012
    Abstract: Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods. Such assays may be employed alone or in combination with other disease screening techniques.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: December 24, 2002
    Assignee: Exact Sciences Corporation
    Inventor: Steven Laken
  • Methods for purifying DNA using immobilized capture probes
    Publication number: 20020172955
    Abstract: Methods employing purification devices comprising an electrophoretic medium containing immobilized capture probes for the purification of DNA are disclosed.
    Type: Application
    Filed: August 24, 2001
    Publication date: November 21, 2002
    Applicant: EXACT Sciences Corporation
    Inventors: Christopher P. Adams, T. Christian Boles, Lawrence Weir, Rahul K. Dhanda, Nevin M. Summers
  • Methods for detecting mutations using primer extension
    Patent number: 6482595
    Abstract: Methods for detecting nucleotide deletions in biological samples are described. Methods of the invention are particulary useful for detecting deletions in regions of polynucleotide repeats. In particular, methods of the invention are useful to detect deletions at the BAT26 locus.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: November 19, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, William Pierceall
  • Methods for detecting mutations using primer extension for detecting disease
    Patent number: 6475738
    Abstract: Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods. Such assays may be employed alone or in combination with other disease screening techniques.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: November 5, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, William Pierceall
  • Detection of non-viral organisms with SRP RNA
    Publication number: 20020123060
    Abstract: The present invention provides rapid detection methods that detect virtually all non-viral organisms, from a broad to a narrow spectrum. More particularly, the present invention provides SRP RNA nucleic acid probes and methods of using such nucleic acid probes for the rapid, sensitive detection of non-viral organisms such as bacteria, fungi, and protozoa. Using the detection methods of the present invention, major non-viral groups such as bacterial, fungi, and protozoa, as well as specific species, can be identified in samples. In addition, kits for use in carrying out the methods of the present invention are provided.
    Type: Application
    Filed: December 19, 2001
    Publication date: September 5, 2002
    Applicant: EXACT Sciences Corporation
    Inventors: T. Christian Boles, Lawrence Weir, Benjamin B. Stone
  • Method for alteration detection
    Patent number: 6428964
    Abstract: Methods are provided for detecting an alteration in a target nucleic acid. Methods of the invention are useful for detecting and identifying mutations that are indicative of disease or the predisposition for disease.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: August 6, 2002
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Stool specimen collector
    Patent number: 6415455
    Abstract: The invention provides an apparatus for obtaining a stool specimen. The apparatus comprises a housing, a collection bag, a slider to close the collection bag and a draw string to move the slider. A user places the apparatus on a toilet, deposits a first stool into the collection bag, then pulls the draw string to move the slider to close the collection bag thereby allowing the user to urinate or further defecate.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: July 9, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Walker M. Slaon, III, Stanley N. Lapidus
  • Methods for stool sample preparation
    Patent number: 6406857
    Abstract: The present invention provides methods for the preparation of stool samples to increase the yield of relevant DNA, and further provides methods for isolating and analyzing target DNA for characteristics indicative of colorectal cancer. Methods for screening patients for the presence of cancerous or pre-cancerous colorectal lesions are also provided.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: June 18, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, Stanley N. Lapidus, Gail E. Radcliffe
  • Stool specimen collector
    Patent number: 6351857
    Abstract: An apparatus for obtaining a stool specimen. The apparatus comprises a housing, a collection bag, a slider to close the collection bag and a draw string to move the slider. A user places the apparatus on a toilet, deposits a first stool into the collection bag, then pulls the draw string to move the slider to close the collection bag thereby allowing the user to urinate or further defecate.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: March 5, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Walker M. Slaon, III, Stanley N. Lapidus
  • Methods for the detection of nucleic acids
    Patent number: 6300077
    Abstract: Methods are provided for identifying nucleic acids. Methods of the invention are useful for identifying and analyzing nucleic acids, especially variants of single nucleotide polymorphisms, that are indicative of disease or the predisposition for disease.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: October 9, 2001
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, Stanley N. Lapidus