Abstract: The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

Abstract: The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-? and anti-TGF-?1 action for the treatment of hepatic fibrosis.

Abstract: Tether-based reaction control systems for spacecraft undergoing atmospheric entry or reducing orbital energy, including systems that use atmospheric drag on one or more tethers to alter the angle of attack of the spacecraft during its atmospheric transit to reduce the thermal and mechanical loads on the spacecraft during the reentry process. Systems may include tethers that together generate a force that functionally acts on the spacecraft at a point that is offset from the spacecraft's center of mass. Such systems may be either actively or passively controlled.

Abstract: Tether-based reaction control systems for spacecraft undergoing atmospheric entry or reducing orbital energy, including systems that use atmospheric drag on one or more tethers to alter the angle of attack of the spacecraft during its atmospheric transit to reduce the thermal and mechanical loads on the spacecraft during the reentry process. Systems may include tethers that together generate a force that functionally acts on the spacecraft at a point that is offset from the spacecraft's center of mass. Such systems may be either actively or passively controlled.

Abstract: A crossbow including at least one trigger assembly that may have a string catch, a sear, a trigger actuator, and an anti-dry-fire mechanism. The anti-dry-fire mechanism can include (i) a bolt sensor movable between a bolt-absent position and a bolt-present position, and (ii) a linearly reciprocating sear latch movable between a latched position and an unlatched position and biased toward the latched position. The bolt sensor may be pivotably coupled to the sear latch so that (i) with the bolt sensor in the bolt-absent position, the sear latch is held in the latched position by bias force thereon, and (ii) with the bolt sensor held in the bolt-present position, the sear latch is held in the unlatched position against the bias force thereon. When in the latched position, the sear latch can prevent movement of the sear.

Abstract: Tether-based reaction control systems for spacecraft undergoing atmospheric entry or reducing orbital energy, including systems that use atmospheric drag on one or more tethers to alter the angle of attack of the spacecraft during its atmospheric transit to reduce the thermal and mechanical loads on the spacecraft during the reentry process. Systems may include tethers that together generate a force that functionally acts on the spacecraft at a point that is offset from the spacecraft's center of mass. Such systems may be either actively or passively controlled.

Abstract: The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-? and anti-TGF-?1 action for the treatment of hepatic fibrosis.

Abstract: The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

Abstract: The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the prior art and which can be used in treatment for the restoration of tissues with fibrotic lesions and for the prevention of fibrotic lesions.

Abstract: The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

Abstract: The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the prior art and which can be used in treatment for the restoration of tissues with fibrotic lesions and for the prevention of fibrotic lesions.

Abstract: The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

Abstract: A multiple-shot crossbow includes a mainframe, a riser, upper and lower bow limbs and bowstrings, and a trigger mechanism. The mainframe includes upper and lower rails, each for supporting and guiding a corresponding bolt. The riser includes a passage for accommodating loading and launching a bolt. The bow limbs are attached to the riser and the bowstrings are attached to the bow limbs. Each bowstring is arranged independently to be drawn from a brace position to a drawn position and then return to the brace position while launching a bolt positioned on the corresponding rail. The lower bowstring is movable within a longitudinal slot between the upper and lower rails. The trigger mechanism is attached to a rear end of the mainframe and includes upper and lower trigger portions, each retaining a corresponding drawn bowstring and then releasing it upon actuation by a user.

Abstract: The present invention relates to the use of a pharmaceutical composition in the form of extended-release tablets containing Pirfenidone for treating NAFLD/NASH and advanced liver fibrosis by decreased serum cholesterol and triglycerides as well as reducing the content of hepatic fat accumulation, both in the form of macrosteatosis and microsteatosis. Additionally, its use as an agonist for PPARgamma (peroxisome proliferation receptor activated gamma), PPARalpha (peroxisome proliferation receptor activated alpha), LXR and CPT1, key molecules in the metabolism of fatty degradation and inflammation of the liver. In addition, another use is the induction of decreased expression of NFkB master gene, transcriptional inducer of hepatic inflammatory process factor. All of these events results in the reversal of NAFLD/NASH and advanced liver fibrosis.

Abstract: The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

Abstract: Provided herein are methods and uses involving pirfenidone pharmaceutical compositions (e.g., extended-release pirfenidone pills (e.g., tablets)) in treating COVID-19, treating and/or preventing viremia and/or viremia-induced disease caused by a virus, and/or an infection with a virus (e.g., DNA virus, RNA virus, for example, coronavirus (e.g., severe acute respiratory syndrome coronavims-2 (SARS-CoV-2) and variants thereof, severe acute respiratory syndrome-associated coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV)), in a subject (e.g., subject with COVID-19). Provided are methods of reducing elevated levels of one or more markers of inflammation (e.g., CRP, ferritin, LDH), inhibiting an inflammatory response (e.g., virus-induced) and/or inhibiting a cascade by one or more pro-inflammatory cytokines (e.g., TNF-?, IEN-?, IL-I?, IL-6, IL-12) and/or in a subject (e.g., a subject with COVID-19 optionally having liver contraindications for pirfenidone).

Abstract: A nock for an archery arrow or bolt. The nock includes a radial indention configured to be engaged by a biased retainer of a trigger mechanism of a crossbow to retain the arrow or bolt in a desired position relative to the trigger mechanism and/or a bowstring. The radial indention may optionally comprise a groove defined generally continuously around a circumference of the nock. The radial indention is exposed when the nock is coupled with an arrow or bolt such that the radial indention may be engaged by a biased retainer within the trigger mechanism. The nock may further include a generally planar rearward bearing surface configured for being engaged by a bowstring. The nock of the present invention may be suitable for use with a multiple-shot crossbow or a single-shot crossbow. Other aspects of the present invention are directed to a projectile, a projectile retention system, and a crossbow.

Abstract: The invention provides topical pharmaceutical gel compositions for the treatment of chronic skin damage, specifically for damage caused by neuropathic ulcers and preferably for the treatment of diabetic foot, and in the treatment of vascular ulcers wherein said compositions comprise a combination of Modified Diallyl Disulfide Oxide (M-DDO) (as an antiseptic/antibiotic agent) and 5-methyl-1-phenyl-2(1H)-pyridone. Furthermore, the invention describes methods of treatment, applications and/or pharmaceutical uses in the preparation of medicaments for eliminating, reducing or preventing chronic skin lesions and the damages caused by neuropathic ulcers and particularly in the treatment of diabetic foot and in the treatment of vascular ulcers.

Abstract: A nock for an archery arrow or bolt. The nock includes a radial indention configured to be engaged by a biased retainer of a trigger mechanism of a crossbow to retain the arrow or bolt in a desired position relative to the trigger mechanism and/or a bowstring. The radial indention may optionally comprise a groove defined generally continuously around a circumference of the nock. The radial indention is exposed when the nock is coupled with an arrow or bolt such that the radial indention may be engaged by a biased retainer within the trigger mechanism. The nock may further include a generally planar rearward bearing surface configured for being engaged by a bowstring. The nock of the present invention may be suitable for use with a multiple-shot crossbow or a single-shot crossbow. Other aspects of the present invention are directed to a projectile, a projectile retention system, and a crossbow.

Abstract: A spacecraft onboard equipment and payload storage system comprising a spacecraft having an interior volume, wherein said interior volume comprises a interior annular portion; a annular storage support track connected to said spacecraft within said spacecraft's interior annular portion; and at least one storage module that is movably connected to said annular storage support track.