Patents Assigned to Excivion Ltd.
  • Glycosylated analogues of Flavivirus E proteins and their use in diagnostic methods
    Patent number: 11401307
    Abstract: The invention relates to isolated recombinant analogues of flavivirus E-proteins comprising an analogue of a flavivirus E-protein fusion loop, wherein the analogue of the flavivirus E-protein fusion loop comprises at least one glycosylation site for an N-linked glycan that is not present in a natural flavivirus E-protein fusion loop sequence, wherein the at least one glycosylation site is an N-linked glycosylation sequon (Asn-X-Ser/Thr) and the Asn (N) residue of the sequon occupies any of positions 98-110 (DRGWGNGCGLFGK) of the natural flavivirus E-protein fusion loop amino acid sequence, wherein X is any amino acid residue except proline and Ser/Thr denotes a serine or threonine residue for use in an in vitro method for specific detection of anti-flavivirus antibody, diagnosis of flavivirus infection and/or to investigate exposure to flavivirus.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 2, 2022
    Assignee: Excivion LTD
    Inventor: Peter Laing
  • Modified flavivirus envelope sequences comprising unique glycosylation sites
    Patent number: 11028133
    Abstract: The invention relates to isolated recombinant analogues of flavivirus E-protein fusion loops comprising at least one glycosylation site for an N-linked glycan that is not present in the natural flavivirus E-protein fusion loop sequence, wherein the at least one glycosylation site is an N-linked glycosylation sequon (Asn-X-Ser/Thr) and the Asn (N) residue of the sequon occupies any of positions 98-110 (SEQ ID NO: 1) (DRGWGNGCGLFGK) of the natural flavivirus E-protein fusion loop amino acid sequence, wherein X is any amino acid residue except proline and Ser/Thr denotes a serine or threonine residue.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: June 8, 2021
    Assignee: Excivion LTD
    Inventor: Peter Laing
  • VARIANT FLAVIVIRUS ENVELOPE SEQUENCES AND USES THEREOF
    Publication number: 20190300580
    Abstract: The invention relates to isolated recombinant analogues of flavivirus E-protein fusion loops comprising at least one glycosylation site for an N-linked glycan that is not present in the natural flavivirus E-protein fusion loop sequence, wherein the at least one glycosylation site is an N-linked glycosylation sequon (Asn-X-Ser/Thr) and the Asn (N) residue of the sequon occupies any of positions 98-110 (DRGWGNGCGLFGK) of the natural flavivirus E-protein fusion loop amino acid sequence, wherein X is any amino acid residue except proline and Ser/Thr denotes a serine or threonine residue.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 3, 2019
    Applicant: Excivion Ltd.
    Inventor: Peter LAING