Patents Assigned to EXOGENESIS
  • Patent number: 11735432
    Abstract: A method for removing amorphous regions from a surface of a crystal substrate uses an accelerated neutral beam including reactive gas species for removing or reactively modifying material surfaces without sputtering. Accelerated neutral atom beam enabled surface reactions remove surface contaminants from substrate surfaces to create an interface region with exposed crystal lattice in preparation for next phase processing.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: August 22, 2023
    Assignee: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Kiet A. Chau, Thy Yam, Michael J. Walsh
  • Patent number: 10342900
    Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: July 9, 2019
    Assignee: EXOGENESIS
    Inventors: Richard C. Svrluga, Sean R. Kirkpatrick, Stephen M. Blinn
  • Patent number: 10209617
    Abstract: A method for treating a substrate surface uses Neutral Beam irradiation derived from a gas-cluster ion-beam and articles produced thereby including lithography photomask substrates.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: February 19, 2019
    Assignee: EXOGENESIS CORPORATION
    Inventor: Sean R. Kirkpatrick
  • Patent number: 10202684
    Abstract: A method for Neutral Beam irradiation derived from gas cluster ion beams and articles produced thereby including optical elements.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: February 12, 2019
    Assignee: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick, Michael J. Walsh
  • Patent number: 10181402
    Abstract: A method of treating a surface of a silicon substrate forms an accelerated gas cluster ion beam of carbon atoms, promotes fragmentation and/or dissociation of gas cluster ions in the beam, removes charged particles from the beam to form a neutral beam, and treats a portion of a surface of the silicon substrate by irradiating it with the neutral beam. A silicon substrate surface layer of SiCX (0.05<X<3) formed by accelerated and focused Neutral Beam irradiation of a silicon substrate wherein the Neutral Beam is derived from a gas cluster ion beam which has had its cluster ions dissociated and charged particles removed.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: January 15, 2019
    Assignee: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick, Michael J. Walsh, Richard C. Svrluga
  • Publication number: 20150294838
    Abstract: A method of improving the surface of an object treats the surface with a neutral beam formed from a gas cluster ion mean to create a surface texture and/or increase surface area.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 15, 2015
    Applicant: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick, Michael J. Walsh, Richard C. Svrluga
  • Publication number: 20140021343
    Abstract: An apparatus, method and products thereof provide an accelerated neutral beam derived from an accelerated gas cluster ion beam for processing materials.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 23, 2014
    Applicant: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick
  • Publication number: 20130218264
    Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
    Type: Application
    Filed: August 22, 2012
    Publication date: August 22, 2013
    Applicant: EXOGENESIS CORPORATION
    Inventors: Richard C. Svrluga, Sean R. Kirkpatrick, Stephen M. Blinn
  • Publication number: 20130138213
    Abstract: A method of modifying a surface of implantable medical device provides coating at least a first portion of the surface of the medical device with a therapeutic agent to form a coated surface region; and irradiating at least a portion of the coated surface region with a gas cluster ion beam infusing the therapeutic agent into the at least a portion of the coated surface region.
    Type: Application
    Filed: January 22, 2013
    Publication date: May 30, 2013
    Applicant: EXOGENESIS CORPORATION
    Inventor: EXOGENESIS CORPORATION
  • Publication number: 20130138212
    Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titanic or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration.
    Type: Application
    Filed: January 22, 2013
    Publication date: May 30, 2013
    Applicant: EXOGENESIS CORPORATION
    Inventors: Richard C. Svrluga, Laurence B. Tarrant
  • Publication number: 20130105710
    Abstract: An apparatus and method for characterizing a particle beam provides receiving a particle beam in a central region of a reduced pressure enclosure; impacting the received beam against a beam strike that is thermally isolated from the enclosure; measuring a temperature change of the beam strike due to the impacting beam; measuring a pressure change in the enclosure due to receiving the beam; and processing the measured temperature change and the measured pressure change to determine beam characteristics.
    Type: Application
    Filed: October 25, 2012
    Publication date: May 2, 2013
    Applicant: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick
  • Publication number: 20130024004
    Abstract: A method of disinfecting a biological material provides disposing at least a portion of the biological material in the path of the gas cluster ion beam or in the path of the accelerated neutral beam so as to irradiate at least a portion of the biological material to disinfect the irradiated portion.
    Type: Application
    Filed: January 25, 2012
    Publication date: January 24, 2013
    Applicant: EXOGENESIS CORPORATION
    Inventors: Joseph Khoury, Sean R. Kirkpatrick
  • Publication number: 20130022494
    Abstract: Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation or by accelerated Neutral Beam are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses. The accelerated Neutral Beam is derived from an accelerated GCIB.
    Type: Application
    Filed: January 25, 2012
    Publication date: January 24, 2013
    Applicant: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Richard C. Svrluga, Joseph Khoury
  • Publication number: 20120321707
    Abstract: In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.
    Type: Application
    Filed: August 28, 2012
    Publication date: December 20, 2012
    Applicant: EXOGENESIS CORPORATION
    Inventors: Stephen M. Blinn, Richard C. Svrluga
  • Publication number: 20120045615
    Abstract: An apparatus, method and products thereof provide an accelerated neutral beam derived from an accelerated gas cluster ion beam for processing materials.
    Type: Application
    Filed: August 23, 2011
    Publication date: February 23, 2012
    Applicant: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick
  • Publication number: 20110300599
    Abstract: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provides a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cell, and for an article for medical implantation. Improvements result from the application of gas-cluster ion beam technology and from the application of neutral beam technology, wherein neutral beams are derived from accelerated gas-cluster ion beams.
    Type: Application
    Filed: May 5, 2011
    Publication date: December 8, 2011
    Applicant: EXOGENESIS CORPORATION
    Inventors: Joseph Khoury, Laurence Berlowitz Tarrant, Sean R. Kirkpatrick, Richard C. Svrluga
  • Publication number: 20110160845
    Abstract: In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.
    Type: Application
    Filed: March 7, 2011
    Publication date: June 30, 2011
    Applicant: EXOGENESIS CORPORATION
    Inventors: Stephen M. Blinn, Richard C. Svrluga
  • Publication number: 20110155897
    Abstract: A gas-cluster-jet generator with improved vacuum management techniques and apparatus is disclosed. The gas-cluster-jet generator comprises a substantially conically shaped vacuum chamber for housing the nozzle and jet exit portions of the gas-cluster-jet generator. A skimmer may be located at the narrow end of the conical chamber and a close-coupled vacuum pump is located at the wide end of the conical chamber. Support members for the nozzle are high conductivity “spider” supports that provide support rigidity while minimizing gas flow obstruction for high pumping speed. The conically shaped vacuum chamber redirects un-clustered gas in a direction opposite the direction of the gas-cluster-jet for efficient evacuation of the un-clustered gas. The nozzle and a skimmer may have fixed precision relative alignment, or may optionally have a nozzle aiming adjustment feature for aligning the gas-cluster-jet with the skimmer and downstream beamline components.
    Type: Application
    Filed: June 29, 2010
    Publication date: June 30, 2011
    Applicant: EXOGENESIS CORPORATION
    Inventor: Stanley Harrison
  • Publication number: 20110029068
    Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.
    Type: Application
    Filed: August 5, 2010
    Publication date: February 3, 2011
    Applicant: EXOGENESIS CORPORATION
    Inventors: Sean R. Kirkpatrick, Richard C. Svrluga
  • Publication number: 20100234948
    Abstract: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provide a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cells, and for an article for medical implantation.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 16, 2010
    Applicant: EXOGENESIS CORPORATION
    Inventors: Joseph Khoury, Laurence B. Tarrant, Sean R. Kirkpatrick, Richard C. Svrluga