Abstract: The present invention relates to an extracorporeal shock wave device for loading a target substance into a delivery vehicle. According to the present invention, the time taken to load the target substance into the delivery vehicle can be significantly reduced, and the loading rate can also be greatly improved.

Abstract: The present invention relates to an extracellular vesicle including a coronavirus-derived antigen protein or a gene encoding the protein, and a use of the extracellular vesicle. According to the present invention, when mice are immunized by administering an activated immune cell-derived extracellular vesicle loaded with an antigen protein or mRNA, excellent antigen-specific neutralizing antibody production and T cell response induction effects are confirmed. When the extracellular vesicle is stored under room-temperature and refrigerated conditions after freeze-drying, high stability and an excellent antibody production effect are experimentally confirmed.