Patents Assigned to ExOxEmis, Inc.
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Patent number: 11389514Abstract: Compositions comprising a combination of myeloperoxidase and a peroxide-producing oxidase and methods of using the compositions to inactivate gram negative bacterial lipopolysaccharides and lipid A endotoxin are provided.Type: GrantFiled: April 13, 2017Date of Patent: July 19, 2022Assignee: EXOXEMIS, INC.Inventor: Robert C. Allen
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Patent number: 9814234Abstract: Compositions comprising a heme-haloperoxidase and an amino alcohol effective for killing or inhibiting the growth of pathogenic microorganisms in the presence of a peroxide and halide and methods of use are provided.Type: GrantFiled: January 9, 2015Date of Patent: November 14, 2017Assignee: EXOXEMIS, INC.Inventors: Jackson T. Stephens, Jr., Matthew J. Pete
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Patent number: 9782459Abstract: Eosinophil peroxidase compositions and methods of their use for killing and/or inhibiting the growth of susceptible microorganisms are provided. The compositions include an eosinophil peroxidase, a peroxide or peroxide source, and amino acids glycine, L-alanine, and L-proline.Type: GrantFiled: January 8, 2014Date of Patent: October 10, 2017Assignee: EXOXEMIS, INC.Inventors: Jackson T. Stephens, Jr., Matthew J. Pete
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Patent number: 8945540Abstract: Methods and compositions are provided for inhibiting the growth of susceptible microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with myeloperoxidase and at least two activity enhancing agent amino acids.Type: GrantFiled: May 9, 2008Date of Patent: February 3, 2015Assignee: Exoxemis, Inc.Inventors: Sophie Becquerelle, William Haag, Obsidiana Abril-Horpel, Shri Valvani
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Publication number: 20140120076Abstract: Eosinophil peroxidase compositions and methods of their use for killing and/or inhibiting the growth of susceptible microorganisms are provided. The compositions include an eosinophil peroxidase, a peroxide or peroxide source, and amino acids glycine, L-alanine, and L-proline.Type: ApplicationFiled: January 8, 2014Publication date: May 1, 2014Applicant: Exoxemis, Inc.Inventors: Jackson T. Stephens, JR., Matthew J. Pete
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Publication number: 20090280102Abstract: Methods and compositions are provided for inhibiting the growth of susceptible microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with myeloperoxidase and at least two activity enhancing agent amino acids.Type: ApplicationFiled: May 9, 2008Publication date: November 12, 2009Applicant: EXOXEMIS, INC.Inventors: Sophie Becquerelle, William Haag, Obsidiana Abril-Horpel, Shri Valvani
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Patent number: 6503507Abstract: Methods and compositions are disclosed for producing air-activated, i.e., oxygen (O2) activated, disinfectant-sterilent solutions. Solutions containing a haloperoxidase (i.e., a halide:hydrogen peroxide (H2O2) oxidoreductase, such as myeloperoxidase, eosinophil peroxidase or lactoperoxidase) plus a halide or combination of halides (i.e., chloride, bromide and/or iodide), an oxidase (i.e., a substrate:O2 oxidoreductase) capable of generating H2O2, and a substrate specific for that oxidase, are separately prepared under aerobic conditions, but all of the component solutions are made anaerobic prior to final combination and mixing. The anaerobic formulations are dispensed into containers capable of maintaining the anaerobic condition (e.g., pressurized canisters). Dispensing the solution at the time of use exposes the formulation to air (i.e., O2) which activates its disinfectant-sterilent properties. O2 is the rate limiting component for oxidase generation of H2O2.Type: GrantFiled: March 6, 2000Date of Patent: January 7, 2003Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Method for inhibiting pathogenic microbes in an animal using a haloperoxidase-halide-peroxide system
Patent number: 6294168Abstract: Haloperoxidases are used to selectively bind to and, in the presence of peroxide and halide, inhibit the growth of target microbes without eliminating desirable microbes or significantly damaging other components, such as host cells, in the environment of the target microbe. When a target microbe, e.g., a pathogenic microbe, has a binding capacity for haloperoxidase greater than that of a desired microbe, e.g., members of the normal flora, the target microbe selectively binds the haloperoxidase with little or no binding of the haloperoxidase by the desired microbe. In the presence of peroxide and halide, the target bound haloperoxidase catalyzes halide oxidation and facilitates the disproportionation of peroxide to singlet molecular oxygen at the surface of the target microbe. The lifetime of singlet molecular oxygen restricts damage to the surface resulting in selective killing of the target microbe with a minimum of collateral damage to the desired microbe or physiological medium.Type: GrantFiled: July 7, 1994Date of Patent: September 25, 2001Assignee: ExOxEmis, Inc.Inventor: Robert Charles Allen -
Patent number: 6033662Abstract: Methods and compositions are disclosed for producing air-activated, i.e., oxygen (O.sub.2) activated, disinfectant-sterilent solutions. Solutions containing a haloperoxidase (i.e., a halide:hydrogen peroxide (H.sub.2 O.sub.2) oxidoreductase, such as myeloperoxidase, eosinophil peroxidase or lactoperoxidase) plus a halide or combination of halides (i.e., chloride, bromide and/or iodide), an oxidase (i.e., a substrate:O.sub.2 oxidoreductase) capable of generating H.sub.2 O.sub.2, and a substrate specific for that oxidase, are separately prepared under aerobic conditions, but all of the component solutions are made anaerobic prior to final combination and mixing. The anaerobic formulations are dispensed into containers capable of maintaining the anaerobic condition (e.g., pressurized canisters). Dispensing the solution at the time of use exposes the formulation to air (i.e., O.sub.2) which activates its disinfectant-sterilent properties. O.sub.2 is the rate limiting component for oxidase generation of H.sub.2 O.Type: GrantFiled: April 7, 1998Date of Patent: March 7, 2000Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Patent number: 5565197Abstract: Methods and compositions for the prophylaxis and/or treatment of sexually transmitted diseases (STDs) are disclosed, in which amounts of a haloperoxidase, such as myeloperoxidase or eosinophil peroxidase, and a semen substrate-specific oxidase are administered to a human or animal subject in the environment of sexually transmitted fluids. In the presence of semen, the semen substrate-specific oxidase catalyzes the production of hydrogen peroxide, which in turn is utilized by the haloperoxidase to selectively inhibit pathogenic microbes present in the sexually transmitted fluids. At high concentration levels, the compositions additionally exhibit spermicidal properties.Type: GrantFiled: January 12, 1995Date of Patent: October 15, 1996Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Patent number: 5556758Abstract: A highly sensitive chemiluminescent indicator system is disclosed for determining the presence or amount of an analyte in a liquid sample. The new acid optimum chemiluminescent indicator system comprises haloperoxidase (halide:hydrogen peroxide oxidoreductase), halide, oxidant and chemiluminigenic substrate. The indicator system acts as a synthesizer of highly reactive singlet molecular oxygen (.sup.1 O.sub.2), which reacts with the chemiluminigenic substrate to yield an excited state, oxidized reaction product. The excited state reaction product then relaxes to a lower energy (e.g., ground) state with the emission of measurable light in an amount related to the amount of each of the reaction participants present in a reaction solution. Known, non-rate limiting amounts of three of the reaction participants are provided in an assay solution to determine the presence or amount of the fourth participant in a test sample.Type: GrantFiled: May 19, 1994Date of Patent: September 17, 1996Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Patent number: 5510104Abstract: Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with a haloperoxidase and at least one antimicrobial activity enhancing agent. Suitable antimicrobial activity enhancing agents include certain .alpha.-amino acids, and are preferably compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, an unsubstituted, or hydroxy or amino substituted, straight or branched chain alkyl group having from 1 to 6 carbon atoms, or an unsubstituted, or hydroxy or amino substituted arylalky group having from 7 to 12 carbon atoms, and R.sub.2 is hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms.Type: GrantFiled: June 1, 1995Date of Patent: April 23, 1996Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Patent number: 5451402Abstract: Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with a haloperoxidase and at least one antimicrobial activity enhancing agent. Suitable antimicrobial activity enhancing agents include certain .alpha.-amino acids, and are preferably compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, an unsubstituted, or hydroxy or amino substituted, straight or branched chain alkyl group having from 1 to 6 carbon atoms, or an unsubstituted, or hydroxy or amino substituted arylalky group having from 7 to 12 carbon atoms, and R.sub.2 is hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms.Type: GrantFiled: November 22, 1994Date of Patent: September 19, 1995Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Patent number: 5389369Abstract: Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or bromide, with a haloperoxidase and at least one antimicrobial activity enhancing agent. Suitable antimicrobial activity enhancing agents include certain .alpha.-amino acids, and are preferably compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, an unsubstituted, or hydroxy or amino substituted, straight or branched chain alkyl group having from 1 to 6 carbon atoms, or an unsubstituted, or hydroxy or amino substituted arylalky group having from 7 to 12 carbon atoms, and R.sub.2 is hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms.Type: GrantFiled: August 2, 1993Date of Patent: February 14, 1995Assignee: ExOxEmis, Inc.Inventor: Robert C. Allen
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Patent number: 5108899Abstract: The presence or amount of in vivo inflammation of a patient is determined by comparing the extent of opsonin receptor expression in vivo on phagocytes of a patient with the maximum opsonin receptor expression inducible on phagocytes of the patient in vitro after stimulation with a receptor expression priming agent.Type: GrantFiled: October 31, 1989Date of Patent: April 28, 1992Assignee: EXOxEmis, Inc.Inventor: Robert C. Allen