Patents Assigned to Expanscience
  • Patent number: 8349377
    Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: January 8, 2013
    Assignee: Laboratoires Expanscience
    Inventors: Antoine Piccirilli, Nathalie Piccardi, Philippe Msika, François Paul, Stéphanie Bredif
  • Patent number: 8318186
    Abstract: The invention concerns the use of at least a fatty ester for preparing a composition designed to inhibit 5?-reductase activity. Said use produces a remarkable inhibiting effect of 5?-reductase thereby providing a novel response for treating dermatological pathologies and/or disorders related to congenital or acquired exaggeration of 5?-reductase activity, in particular for treating prostatic hypertrophy, prostatic adenoma, acne, hyperseborrhea, alopecia and hirsutism. The invention also concerns cosmetic treatment methods, in particular for greasy skin, and the use of said fatty esters as additives in a food product for human and/or animal consumption.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: November 27, 2012
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli, Jacques Legrand
  • Publication number: 20120294887
    Abstract: The invention relates to a method for the solid/liquid extraction of an oil or butter, particularly having a high unsaponifiable content, contained in at least one solid vegetable matter or a micro-organism. The method includes at least the following steps: solid/liquid extraction of at least one solid vegetable matter or a micro-organism using a first solvent system comprising a concentration of solvent selected from among fluorinated aromatic solvents, particularly trifluorotoluene (BTF) and hexafluorobenzene (BHF), tert-butyl ethers, particularly 2-ethoxy-2-methylpropane, also known as ethyl-tert-butyl-ether (ETBE), and 2-methoxy-2-methylpropane or methyl-tert-butylether (MTBE), solvents comprising at least one silicon atom, particularly hexamethyldisiloxane (HMDS) and tetramethylsilane (TMS), methyl-tetrahydrofuran (MeTHF), and mixtures thereof, representing at least 50 vol.
    Type: Application
    Filed: January 31, 2011
    Publication date: November 22, 2012
    Applicant: LABORATORIES EXPANSCIENCE
    Inventors: Alex Saunois, Jacques Legrand, Eglantine Mercier
  • Patent number: 8304453
    Abstract: The invention concerns a composition containing at least an alkanolamide, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an oxazolin, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular its use for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such a composition on the skin and/or mucosa.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: November 6, 2012
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Nathalie Piccardi, Antoine Piccirilli
  • Patent number: 8236836
    Abstract: The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: August 7, 2012
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Nathalie Piccardi, Antoine Piccirilli
  • Patent number: 8231916
    Abstract: The present invention concerns the use of a rice protein hydrolysate in order to pigment the skin and skin appendages. Thus, it is possible to intensify the normal pigmentation of the skin without sunlight. Preferred areas of applications are repigmentation of white patches of the skin, repigmentation of white patches of the skin as a consequence of pityriasis or due to the use of dermocorticoids; acceleration and intensification of the tanning process, stimulation of the constitutive photoprotection and improvement of the phototype, prevention of skin photocarcinogenesis. Advantageously, the rice protein hydrolysate comprises peptides of which at least 50% have a molecular mass in the range of between 300 and 3,500 Da.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: July 31, 2012
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Dalale Naaïmi
  • Patent number: 8147883
    Abstract: The invention concerns the use of at least a vegetable oil product selected among the group consisting of vegetable oil oleic distillates, vegetable oil unsaponifiable matters, vegetable oil furan lipids and mixtures thereof, as agents for increasing skin lipid synthesis, in particular lipids of the epidermal skin barrier, in or for preparing a composition containing a pharmaceutically or dermatologically acceptable medium. The use enables to prevent and/or treat deterioration of the skin barrier (dry skin, skin subjected to actinic radiation, ichthyosis, acne, xerosis, atopic dermatitis, sensitive skin, chafing and reactive skin, itching and the like).
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: April 3, 2012
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli
  • Patent number: 8053003
    Abstract: The present invention relates to the use of a plant oil product as an agent for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, in or for the preparation of a cosmetic, pharmaceutical or dermatological composition. The invention also relates to a method for cosmetic treatment with a cosmetic, pharmaceutical or dermatological composition for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, and to the use of the plant product as a food additive.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: November 8, 2011
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli
  • Patent number: 7897579
    Abstract: The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract and/or a peptidic lupin extract.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: March 1, 2011
    Assignee: Laboratoires Expanscience
    Inventors: Antoine Piccirilli, Nathalie Piccardi, Philippe Msika, François Paul, Stéphanie Bredif
  • Patent number: 7883729
    Abstract: The invention concerns a natural vegetable oil selected among palm oil, corn germ oil, sunflower oil and canola oil, concentrated in unsaponifiable matters, such that said oil unsaponifiable matter content is 3 to 15% m/m. Said concentrated natural vegetable oil constitutes a novel food ingredient enriched in particular in vitamin E and phytosterol, useful as favored food source in vitamin E and phytosterol, meeting recommended daily intake.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: February 8, 2011
    Assignee: Laboratories Expanscience
    Inventors: Carole Kohler, Philippe Msika, Antoine Piccirilli
  • Patent number: 7872043
    Abstract: The invention relates to the use of one or several synthetic or natural furan alkyls for cosmetically treating cellulite. Said furan alkyls preferably correspond to formula (I), wherein identical or different R1, R2, R3et R4 are independently of each other a hydrogen atom, a C1-C35alkyl radical, C1-C35 alcenyl radical or a C1-C35 alcynyl radical, preferably C10-C22, wherein said alkyl, alcenyl and alcynyl radicals are substitutable and R1, R2, R3 are preferably a hydrogen atom.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: January 18, 2011
    Assignee: Laboratories Expanscience
    Inventors: Antoine Piccirilli, Philippe Msika, Nathalie Piccardi
  • Patent number: 7863472
    Abstract: The present invention concerns a process for producing refined avocado oil rich in triglycerides. The invention also pertains to refined avocado oil rich in triglycerides obtainable by said process. Advantageously, the refined avocado oil of the invention contains a sterols-enriched unsaponifiable fraction. Advantageously, the refined avocado oil of the invention is substantially free of acetogenins and furanic lipids. The invention also concerns compositions containing said oil. The invention also pertains to such compositions for use as a medication, as a dermatological agent, as a cosmetic agent, or as a nutriceutical, for human or animal use.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: January 4, 2011
    Assignee: Laboratories Expanscience
    Inventors: Philippe Msika, Jacques Legrand
  • Patent number: 7833554
    Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: November 16, 2010
    Assignee: Laboratoires Expanscience
    Inventors: Antoine Piccirilli, Nathalie Piccardi, Philippe Msika, François Paul, Stéphanie Bredif
  • Patent number: 7816547
    Abstract: The present invention concerns a process for producing refined avocado oil rich in triglycerides. The invention also pertains to refined avocado oil rich in triglycerides obtainable by said process. Advantageously, the refined avocado oil of the invention contains a sterols-enriched unsaponifiable fraction. Advantageously, the refined avocado oil of the invention is substantially free of acetogenins and furanic lipids. The invention also concerns compositions containing said oil. The invention also pertains to such compositions for use as a medication, as a dermatological agent, as a cosmetic agent, or as a nutriceutical, for human or animal use.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 19, 2010
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Jacques Legrand
  • Patent number: 7763647
    Abstract: The invention relates to compositions intended for external topical use comprising a true solution containing a chromane or chromene derivative having formula (I), preferably a flavonoid, dissolved in a suitable solvent. The invention also relates to a method for preparing such compositions and the use of said compositions as sun protection agents for the skin, advantageously as agents having an anti-erythemal, anti-oxidant, anti-radical, anti-inflammatory or vasculotropic activity.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: July 27, 2010
    Assignee: Laboratories Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli, Nathalie Piccardi, Nicole Broutin
  • Patent number: 7744933
    Abstract: The invention relates to the use of at least one unsaponifiable component of vegetable oil, in particular of avocado, soya bean and/or lupin oils, for the preparation of a medicament intended to stimulate the expression of TGF-? or the expression of the plasminogen activator inhibitor PAI-1. The invention also relates to a method of cosmetic treatment comprising the application of at least one unsaponifiable component of vegetable oil as well as the use of the latter as additive in a food for human beings and/or for animals.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: June 29, 2010
    Assignee: Laboratories Expanscience
    Inventors: Karim Boumediene, Jean-Pierre Pujol, Georges Bernard Guillou, Philippe Msika, Chafik Ghayor
  • Patent number: 7638149
    Abstract: A composition comprising a hydrolyzed peptide extract of a lupin and a method of producing the same.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: December 29, 2009
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli, Francois Paul
  • Patent number: 7629371
    Abstract: The invention relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product, and to an associated cosmetic treatment method. The invention also relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, for preventing and/or treating cellulite.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: December 8, 2009
    Assignee: Laboratoires Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli, Nathalie Piccardi
  • Publication number: 20090286871
    Abstract: The present invention relates to the use of a plant oil product as an agent for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, in or for the preparation of a cosmetic, pharmaceutical or dermatological composition. The invention also relates to a method for cosmetic treatment with a cosmetic, pharmaceutical or dermatological composition for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, and to the use of the plant product as a food additive.
    Type: Application
    Filed: July 20, 2009
    Publication date: November 19, 2009
    Applicant: Laboratoires Expanscience
    Inventors: Philippe Msika, Antoine Piccirilli
  • Patent number: 7589121
    Abstract: The invention relates to the use of one or several synthetic or natural furan alkyls for preparing a drug preventing and/or treating obesity or overweight. The use of one or several synthetic or natural furan alkyls for cosmetically treating local excessive weight is also disclosed. Said furan alkyls preferably correspond to formula (I), wherein identical or different R1, R2, R3et R4 are independently of each other a hydrogen atom, a C1-C35alkyl radical, C1-C35 alcenyl radical or a C1-C35 alcynyl radical, preferably C10-C22, wherein said alkyl, alcenyl and alcynyl radicals are substitutable and R1, R2, R3 are preferably a hydrogen atom.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: September 15, 2009
    Assignee: Laboratoires Expanscience
    Inventors: Antoine Piccirilli, Philippe Msika, Nathalie Piccardi