Patents Assigned to Exponential Biotherapies, Inc.
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Patent number: 7438901Abstract: The present invention relates to virulent (lytic) Listeria monocytogenes phage from the Myoviridae family, preferably P100, alone or in combination with other virulent phages. P100 and the endolysin from P100 can be administered to food products, to the components that will be added to food products, and/or to the infrastructure of the food processing plants within which such food products are processed, or the containers or wraps in which such foods are stored and/or shipped, in order to reduce Listeria monocytogenes contamination. P100 can also be used in the present invention to identify Listeria monocytogenes bacteria present on (or within) foodstuffs, as well as those Listeria monocytogenes bacteria present in the equipment or the general environment of the food processing plants in which the foodstuffs are being processed and in animals infected with Listeria monocytogenes. The phage and the endolysin of the present invention can also be used to treat animals infected with Listeria monocytogenes.Type: GrantFiled: July 7, 2003Date of Patent: October 21, 2008Assignee: Exponential Biotherapies, Inc.Inventors: Martin Loessner, Richard M. Carlton
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Patent number: 7332307Abstract: The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects. The HDS normally reduces the number of bacteriophage in an animal, which decreases the efficiency of the bacteriophage in killing the host bacteria present during an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes by physico-chemical alteration of the bacteriophage surface proteins, so that the altered bacteriophage remain active in the body for longer periods of time than the unmodified bacteriophage.Type: GrantFiled: September 11, 2003Date of Patent: February 19, 2008Assignees: The United States of America as represented by the Department of Health and Human Services, Exponential Biotherapies, Inc.Inventors: Richard M. Carlton, Carl R. Merril, Sankar L. Adhya
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Publication number: 20050175594Abstract: The present invention relates to virulent (lytic) Listeria monocytogenes phage from the Myoviridae family, preferably P100, alone or in combination with other virulent phages. P100 and the endolysin from P100 can be administered to food products, to the components that will be added to food products, and/or to the infrastructure of the food processing plants within which such food products are processed, or the containers or wraps in which such foods are stored and/or shipped, in order to reduce Listeria monocytogenes contamination. P100 can also be used in the present invention to identify Listeria monocytogenes bacteria present on (or within) foodstuffs, as well as those Listeria monocytogenes bacteria present in the equipment or the general environment of the food processing plants in which the foodstuffs are being processed and in animals infected with Listeria monocytogenes. The phage and the endolysin of the present invention can also be used to treat animals infected with Listeria monocytogenes.Type: ApplicationFiled: July 7, 2003Publication date: August 11, 2005Applicant: Exponential Biotherapies, Inc.Inventors: Martin Loessner, Richard Carlton
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Publication number: 20010043924Abstract: The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects. The HDS normally reduces the number of bacteriophage in an animal, which decreases the efficiency of the bacteriophage in killing the host bacteria present during an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes by physico-chemical alteration of the bacteriophage surface proteins, so that the altered bacteriophage remain active in the body for longer periods of time than the unmodified bacteriophage.Type: ApplicationFiled: May 29, 2001Publication date: November 22, 2001Applicant: Exponential Biotherapies, Inc.Inventors: Richard M. Carlton, Carl R. Merril, Sankar L. Adhya
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Publication number: 20010026795Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.Type: ApplicationFiled: May 21, 2001Publication date: October 4, 2001Applicant: Exponential Biotherapies, Inc.Inventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
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Patent number: 5811093Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging of a bacteriophage, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.Type: GrantFiled: April 12, 1996Date of Patent: September 22, 1998Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Department of Health and Human ServicesInventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
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Patent number: 5766892Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.Type: GrantFiled: June 5, 1995Date of Patent: June 16, 1998Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
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Patent number: 5688501Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.Type: GrantFiled: January 29, 1996Date of Patent: November 18, 1997Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya
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Patent number: 5660812Abstract: The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.Type: GrantFiled: June 5, 1995Date of Patent: August 26, 1997Assignees: Exponential Biotherapies, Inc., The United States of America as represented by the Department of Health and Human ServicesInventors: Carl R. Merril, Richard M. Carlton, Sankar L. Adhya