Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
Type:
Grant
Filed:
November 15, 2004
Date of Patent:
August 25, 2009
Assignee:
Expression Diagnostics, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.
Type:
Application
Filed:
April 9, 2007
Publication date:
October 25, 2007
Applicant:
Expression Diagnostics, Inc.
Inventors:
Preeti Lal, Steven Rosenberg, Tod Klinger
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
June 26, 2007
Assignee:
Expression Diagnostics, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice
Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
Type:
Application
Filed:
November 15, 2004
Publication date:
February 15, 2007
Applicant:
EXPRESSION DIAGNOSTICS, INC.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
Type:
Application
Filed:
November 15, 2004
Publication date:
February 15, 2007
Applicant:
EXPRESSION DIAGNOSTICS, INC.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods useful in monitoring the functional status of a transplant in a patient by detecting the expression levels of gene panels are described herein. Algorithms for analysis of the expression for monitoring the functional status of transplants are also described.
Type:
Application
Filed:
May 11, 2006
Publication date:
November 23, 2006
Applicant:
EXPRESSION DIAGNOSTICS, INC.
Inventors:
Steven Rosenberg, Preeti Lal, Kirk Fry, Tod Klingler, Dirk Walther, Robert Woodward
Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
Type:
Grant
Filed:
April 24, 2002
Date of Patent:
April 11, 2006
Assignee:
Expression Diagnostics, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Described herein is a system for monitoring gene expression for diagnosing and monitoring inflammation disorders, and for monitoring gene expression in inflammation disorders in response to a particular drug treatment reginmen. This system for detecting nucleic acid expression in a body fluid uses an isolated polynucleotide to detect expression of a nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 5; SEQ ID NO:11; SEQ ID NO:17; and SEQ ID NO: 23. These nucleic acids are differentially expressed in body fluid in an individual with a disease criterion for a disease as listed in Table 1 as compared to an individual without the disease criterion.
Type:
Application
Filed:
September 8, 2005
Publication date:
March 9, 2006
Applicant:
Expression Diagnostics, Inc.
Inventors:
Jay Wohlgemuth, Darren Tayama, Dirk Walther, Preeti Lal
Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
Type:
Grant
Filed:
April 24, 2002
Date of Patent:
June 14, 2005
Assignee:
Expression Diagnostics, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly