Patents Assigned to Exthera Medical Corporation
  • Publication number: 20200297913
    Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 24, 2020
    Applicant: ExThera Medical Corporation
    Inventors: Olle Larm, Tomas Bergstrom
  • Patent number: 10688239
    Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: June 23, 2020
    Assignee: ExThera Medical Corporation
    Inventors: Olle Larm, Tomas Bergstrom
  • Publication number: 20200171233
    Abstract: The present invention provides methods for removing a significant amount of bacteria (e.g., gram-negative bacteria and gram-positive bacteria, including bacteria with no or low affinity for heparan sulfate) from whole blood, serum or plasma using an adsorption media. The method can be used in extracorporeal treatments involving high volumetric flow rates and high linear flow rates.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 4, 2020
    Applicant: ExThera Medical Corporation
    Inventors: Keith McCrea, Robert Ward
  • Patent number: 10639413
    Abstract: A blood filtration method, system, device and media for removing gram negative bacteria from the blood wherein the media includes a substrate coated with mannose optionally in constitution with substrate coated with heparin.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 5, 2020
    Assignee: Exthera Medical Corporation
    Inventors: Keith McCrea, Robert Ward, Olle Larm, Lars Adolfsson
  • Patent number: 10537280
    Abstract: The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: January 21, 2020
    Assignee: ExThera Medical Corporation
    Inventors: Keith McCrea, Robert S. Ward, George Pitarra, Jr.
  • Patent number: 10487350
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 26, 2019
    Assignee: ExThera Medical Corporation
    Inventors: Robert S. Ward, Keith R. McCrea
  • Patent number: 10457974
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 29, 2019
    Assignee: ExThera Medical Corporation
    Inventors: Robert S. Ward, Keith R. McCrea
  • Publication number: 20190143027
    Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 16, 2019
    Applicant: ExThera Medical Corporation
    Inventors: Olle LARM, Tomas BERGSTROM
  • Publication number: 20190038826
    Abstract: A blood filtration method, system, device and media for removing gram negative bacteria from the blood wherein the media includes a substrate coated with mannose optionally in constitution with substrate coated with heparin.
    Type: Application
    Filed: August 2, 2018
    Publication date: February 7, 2019
    Applicant: ExThera Medical Corporation
    Inventors: KEITH MCCREA, ROBERT WARD, OLLE LARM, LARS ADOLFSSON
  • Patent number: 10188783
    Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: January 29, 2019
    Assignee: ExThera Medical Corporation
    Inventors: Olle Larm, Tomas Bergstrom
  • Publication number: 20180361050
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, Keith R. McCREA, Olle LARM, Lars ADOLFSSON
  • Patent number: 10086126
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 2, 2018
    Assignee: ExThera Medical Corporation
    Inventors: Robert S Ward, Keith R McCrea, Olle Larm, Lars Adolfsson
  • Publication number: 20170340803
    Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
    Type: Application
    Filed: August 16, 2017
    Publication date: November 30, 2017
    Applicant: ExThera Medical Corporation
    Inventors: Olle LARM, Tomas Bergstrom
  • Patent number: 9764077
    Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: September 19, 2017
    Assignee: EXTHERA MEDICAL CORPORATION
    Inventors: Olle Larm, Tomas Bergstrom
  • Patent number: 9669150
    Abstract: The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood com-Components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: June 6, 2017
    Assignee: EXTHERA MEDICAL CORPORATION
    Inventors: Olle Larm, Tomas Bergstrom, Jonas Axelsson, Lars Adolfsson, Robert S. Ward, Keith McCrae
  • Publication number: 20160331886
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Application
    Filed: June 30, 2016
    Publication date: November 17, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, Keith R. McCrea, Olle Larm, Lars Adolfsson
  • Patent number: 9408962
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: August 9, 2016
    Assignee: EXTHERA MEDICAL CORPORATION
    Inventors: Robert S. Ward, Keith R. McCrea, Olle Larm, Lars Adolfsson
  • Publication number: 20160101229
    Abstract: A blood filtration method, system, device and media for removing gram negative bacteria from the blood wherein the media includes a substrate coated with mannose optionally in constitution with substrate coated with heparin.
    Type: Application
    Filed: December 17, 2015
    Publication date: April 14, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: KEITH MCCREA, ROBERT WARD, OLLE LARM, LARS ADOLFSSON
  • Publication number: 20160082177
    Abstract: The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.
    Type: Application
    Filed: September 21, 2015
    Publication date: March 24, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, KEITH R. McCREA
  • Publication number: 20160084835
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Application
    Filed: October 16, 2015
    Publication date: March 24, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, Keith R. McCrea