Patents Assigned to Exxpharma, LLC
  • Process for enhancing the solubility of poorly soluble drugs
    Patent number: 7607596
    Abstract: The solubility/dissolution rate of a poorly soluble drug is enhanced by a process that utilizes a twin-screw extruder containing (i) a feed zone containing a first liquid and powder feed stations; (ii) a grinding/mixing zone containing a second liquid feed port located at an upstream portion of such zone; (iii) a granulation zone containing a second powder feed station located at an upstream portion of such zone and a third liquid feed port located at a downstream portion of such zone; and (iv) a wet milling zone.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: October 27, 2009
    Assignee: Exxpharma, LLC
    Inventors: Isaac Ghebre-Sellassie, Hibrenigus Terefe