Patents Assigned to Eyesense AG
  • Patent number: 10429380
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: October 1, 2019
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 9826926
    Abstract: The invention relates to a sensor element for detecting at least one analyte in a body fluid or in a body tissue, particularly for determining at least one metabolite concentration in a body fluid. The sensor element comprises an implantable, one-piece shaped body, which comprises a sensor end and a coupling end. The shaped body comprises, in the area of the sensor end, at least one sensor area, which comprises at least one sensor material. The sensor material changes at least one optically measurable property in the presence of the analyte. The shaped body also has at least one optically transparent coupling part, which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area and the coupling end. In the sensor area, the shaped body has at least one optically transparent matrix material, and the analyte can at least partially diffuse through the matrix material to the sensor material. The sensor material is embedded in the matrix material.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: November 28, 2017
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Publication number: 20160196235
    Abstract: A method and an apparatus for determining at least one smoothed data point (tk, sk) within a stream of data points {ti, si} with 1?i?z, k<z is disclosed. Herein, the stream of data points {ti, si} is consecutively acquired in a manner that a data point (ti, si) is acquired after an acquisition of a preceding data point (ti-1, si-1), wherein each data point (ti, si) comprises a valid value or an invalid value or a missing value for the signal si at a time ti. Herein, the signal si at the time ti comprises physical, chemical, biological, environmental, and/or technical data acquired by means of a technical set-up. According to the method, a set of data points is provided, wherein for each smoothed data point (tk, sk) a smoothing set is created. For each smoothed data point (tk, sk), trailing data resulting from large gaps are removed until it is verified whether the smoothing set comprises a minimal number of data points.
    Type: Application
    Filed: August 4, 2014
    Publication date: July 7, 2016
    Applicant: EyeSense AG
    Inventors: Frank Küster, Roland Krivànek, Achim Müller
  • Patent number: 9244064
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: January 26, 2016
    Assignee: EYESENSE AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 8945942
    Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: February 3, 2015
    Assignee: Eyesense AG
    Inventors: Peter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
  • Patent number: 8652101
    Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: February 18, 2014
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Patent number: 8647271
    Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: February 11, 2014
    Assignee: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 8452361
    Abstract: An ocular sensor (110) is proposed for verification of at least one analyte in an eye fluid. The ocular sensor (110) is composed of at least one sensor material which is designed to change at least one optical characteristic in the presence of the at least one analyte. Furthermore, the ocular sensor (110) comprises at least one sensor chip which has at least one integrated optical detector (122) for verification of the optical characteristic. A measurement system (166) is also proposed for verification of at least one analyte in an eye fluid, which measurement system (166) comprises an ocular sensor (110) according to the invention as well as an evaluation unit (168) which is designed to interchange information with the sensor chip (118).
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: May 28, 2013
    Assignee: Eyesense AG
    Inventor: Achim Müller
  • Patent number: 8452363
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 28, 2013
    Assignee: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
  • Patent number: 8206622
    Abstract: The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: June 26, 2012
    Assignee: EyeSense AG
    Inventors: Stefan Kammermeier, Till Merkel, Katharina Schmid, Achim Müller
  • Patent number: 8131333
    Abstract: This invention is generally related to a biocompatible sensor for detecting/measuring sugar, especially glucose, in an ocular fluid in a non-invasive or minimally invasive manner and a method for using the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of an ophthalmic device comprising a molecular sensing moiety which interacts or, reacts with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: March 6, 2012
    Assignee: EyeSense AG
    Inventors: L. Lawrence Chapoy, Angelika Maria Domschke, Dawn Smith
  • Patent number: 8057041
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 15, 2011
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
  • Publication number: 20110230835
    Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
    Type: Application
    Filed: October 2, 2009
    Publication date: September 22, 2011
    Applicant: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Publication number: 20110224514
    Abstract: The invention relates to a sensor element (110) for detecting at least one analyte in a body fluid or in a body tissue (130), particularly for determining at least one metabolite concentration in a body fluid. The sensor element (110) comprises an implantable, one-piece shaped body (112), which comprises a sensor end (114) and a coupling end (116). The shaped body (112) comprises, in the area of the sensor end (114), at least one sensor area (118), which comprises at least one sensor material (122). The sensor material (122) changes at least one optically measurable property in the presence of the analyte. The shaped body (112) also has at least one optically transparent coupling part (120), which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area (118) and the coupling end (116).
    Type: Application
    Filed: October 2, 2009
    Publication date: September 15, 2011
    Applicant: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Patent number: 7927519
    Abstract: This invention is generally related to a biocompatible sensor for detecting/measuring an analyte of interest in a body fluid and a method for making the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of a reflection hologram therein or thereon, wherein the reflection hologram is produced in a crosslinkable and/or polymerizable fluid material. The polymer matrix contains a molecular sensing moiety which interacts or reacts with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: April 19, 2011
    Assignee: Eyesense AG
    Inventors: Angelika Maria Domschke, Xiaodong Hu, Jian S. Zhou
  • Publication number: 20100331634
    Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
    Type: Application
    Filed: May 23, 2008
    Publication date: December 30, 2010
    Applicant: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 7772286
    Abstract: The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: August 10, 2010
    Assignee: Eyesense AG
    Inventors: Achim Müller, Roland Schmieder, Katharina Schmid
  • Publication number: 20100063371
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Application
    Filed: July 23, 2007
    Publication date: March 11, 2010
    Applicant: EYESENSE AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh
  • Patent number: 7653424
    Abstract: An apparatus for measuring ocular and/or blood glucose levels comprises (a) an irradiating means (10) for irradiating light onto the eye (1) of a user from outside the cornea of the eye to excite an ocular glucose sensor in contact with an ocular fluid, said sensor being able to emit a total fluorescence having first and a second wavelength bands; (b) an optical path splitting means (11) for splitting said total fluorescence into a first fluorescence and a second fluorescence, said first fluorescence and said second fluorescence traveling along first and second optical paths; (c) a first detecting means (14) located in the first optical path; (d) a second detecting means (17) located in the second optical path; (e) a calculating means for calculating the intensity ratio of the first fluorescence to the second fluorescence and for determining an ocular glucose concentration in the ocular fluid; and (f) an arithmetic means for converting the ocular glucose concentration into a blood glucose concentration.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: January 26, 2010
    Assignee: Eyesense AG
    Inventor: Wayne Front March
  • Patent number: 7406345
    Abstract: The present invention relates to a hand-held fluorescence photometer and method for measuring an analyte level, preferably a blood glucose level, from an ocular fluid. The photometer is based on a dual beams measuring system and it is capable of defining the correct positioning for the measurement. Only when the apparatus is correctly positioned the actual analyte measurement automatically takes place.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: July 29, 2008
    Assignee: Eyesense AG
    Inventors: Achim Müller, Roland Schmieder, Klaus Haberstroh