Patents Assigned to F. Charles Brunicardi
  • Promoter driven tissue specific cytotoxic agents and title methods of use
    Publication number: 20050059620
    Abstract: This invention relates to a recombinant nucleic acid for an RIP-tk (rat insulin promoter-thymidine kinase) construct that selectively targets insulin secreting cells, such as ?-cells, PDX-1 positive human pancreatic ductal carcinomas, and other cells containing certain transcription factors. The present invention is useful in the treatment of pancreatic cancers, such as ?-cell insulinomas and can also be used to target pancreatic tumors that do not express insulin, such as pancreatic adenocarcinoma.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 17, 2005
    Applicant: F. Charles Brunicardi
    Inventor: F. Brunicardi