Patents Assigned to F.I.S. Fabbrica Italiana Sintetiei S.p.A.
  • Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates
    Patent number: 9169236
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 27, 2015
    Assignee: F.I.S.-Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Francesco Fontana, Alfredo Paio
  • Process for the preparation of olopatadine
    Patent number: 8871953
    Abstract: The present invention relates to a novel process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: October 28, 2014
    Assignee: F.I.S. Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Andrea Castellin, Clark Ferrari, Marco Galvagni