Patents Assigned to F2G Ltd.
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Patent number: 11819503Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.Type: GrantFiled: April 22, 2020Date of Patent: November 21, 2023Assignees: F2G LtdInventors: Derek Law, John H. Rex, Michael Birch, Nathan P. Wiederhold, Thomas F. Patterson
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Patent number: 9487813Abstract: A method of identifying an antifungal agent which targets a PPTB protein of a fungus comprising determining whether a candidate compound binds to or inhibits a PPTB protein, wherein binding or inhibition indicates that the candidate substance is an antifungal agent.Type: GrantFiled: June 4, 2010Date of Patent: November 8, 2016Assignee: F2G LTDInventors: Jason David Oliver, Katharine Sarah Dobb, Sarah Jane Kaye, John Leslie Thain, Daniel Scott Tuckwell, Michael John Bromley
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Patent number: 9452168Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: February 18, 2015Date of Patent: September 27, 2016Assignee: F2G LTDInventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Michael Birch, Gareth Morse Davies
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Patent number: 8993574Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: April 23, 2009Date of Patent: March 31, 2015Assignee: F2G LtdInventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Mike Birch, Gareth Morse Davies, Patricia Suling Davies
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Patent number: 8604029Abstract: The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: November 21, 2007Date of Patent: December 10, 2013Assignee: F2G Ltd British Body CorporateInventors: Robert Downham, Graham Edward Morris Sibley, Lloyd James Payne, Philip Edwards, Gareth Morse Davies
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Patent number: 8486962Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: May 18, 2006Date of Patent: July 16, 2013Assignee: F2G Ltd.Inventors: Samantha Patricia Thomson, Rhian Teresa Davies, Nigel Mark Allanson, Alexandre Kuvshinov, Gareth Morse Davies, Philip Neil Edwards
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Publication number: 20080206220Abstract: Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a NADH:flavin oxidoreductase protein which comprises the sequence shown by SEQ ID NO:3, (ii) a NADH:flavin oxidoreductase protein which is a homologue of (i) and which comprises the sequence shown by SEQ ID NO: 8, 12, 14, 19, 24, 42, 44, 83 or 85, (iii) a protein which has 50% identity with (i) or (ii), (iv) a protein comprising a fragment of (i), (ii) or (iii) which fragment has a length of at least 50 amino acids, (v) a polynucleotide that comprises sequence which encodes (i), (ii), (iii) or (iv), (vi) a polynucleotide comprising sequence which has at least 70% identity with the coding sequence of (v), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), (v) or (vi), wherein binding or modulation of (i), (ii), (iii), (iv), (v) or (vi) indicates that the candidate substance is an anti-fungal agent.Type: ApplicationFiled: February 18, 2005Publication date: August 28, 2008Applicant: F2G LTDInventors: Sandra Elizabeth Lavens, Jason David Oliver, John Leslie Thain, Daniel Scott Tuckwell, Michael John Bromley
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Publication number: 20080161302Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: ApplicationFiled: May 18, 2006Publication date: July 3, 2008Applicant: F2G Ltd.Inventors: Samantha Patricia Thomson, Rhian Teresa Davies, Nigel Mark Allanson, Alexandre Kuvshinov, Gareth Morse Davies, Philip Neil Edwards