Abstract: New benzimidazole derivatives of formula: ##STR1## in which R.sub.1 is H or a short chain hydrocarbon group such as methyl, hyl, isopropyl, cyclopropyl, vinyl, etc., and R.sub.2 is a group selected from among the following: CH.sub.2 OH, COOH, COOR.sub.3 and 4,4-dimethyl-2-oxazolinyl, R.sub.3 being a short chain alkyl group such as methyl, ethyl, etc., are described.A description is also made of the preparation of these compounds, which have a high H.sub.1 antihistaminic and antiallergic activity and are devoid of effects on the central nervous and cardiovascular systems.
Type:
Grant
Filed:
June 4, 1997
Date of Patent:
March 2, 1999
Assignee:
Fabrica Espanola de Productos Quimicos y Farmaceuticos S.A. (FAES)
Inventors:
Aurelio Orjales, Victor Rubio, Maravillas Bordell